AVN-101
- CAS No.
- 1061354-48-0
- Chemical Name:
- AVN-101
- Synonyms
- AVN-101 HCl;AVN-101 1061354-48-0;AVN-101, 10 mM in DMSO;2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride;1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-, hydrochloride (1:1)
- CBNumber:
- CB03162602
- Molecular Formula:
- C21H24N2*ClH
- Molecular Weight:
- 340.9
- MDL Number:
- MFCD30738705
- MOL File:
- 1061354-48-0.mol
- MSDS File:
- SDS
| solubility |
DMF: 10 mg/ml DMSO: 5 mg/ml Ethanol: 1 mg/ml |
|---|---|
| form | Solid |
| color | White to light yellow |
| FDA UNII | XML910S5X8 |
AVN-101 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 38791 | AVN-101 (hydrochloride) ≥98% | 1061354-48-0 | 1mg | $33 | 2026-04-30 | Buy |
| Cayman Chemical | 38791 | AVN-101 (hydrochloride) ≥98% | 1061354-48-0 | 5mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 38791 | AVN-101 (hydrochloride) ≥98% | 1061354-48-0 | 10mg | $131 | 2026-04-30 | Buy |
| Cayman Chemical | 38791 | AVN-101 (hydrochloride) ≥98% | 1061354-48-0 | 25mg | $246 | 2026-04-30 | Buy |
| Biosynth | LSB35448 | 2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride | 1061354-48-0 | 50mg | $789 | 2026-06-04 | Buy |
AVN-101 Chemical Properties, Uses, Production
Uses
AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1].
IC 50
5-HT7 Receptor: 0.153 nM (Ki); 5-HT2C Receptor: 1.17 nM (Ki); 5-HT2A Receptor: 1.56 nM (Ki); 5-HT6 Receptor: 2.04 nM (Ki); 5-HT2B Receptor: 10.6 nM (Ki); 5-HT1A Receptor: 61 nM (Ki); 5-HT1B Receptor: 720 nM (Ki); H1 Receptor: 0.58 nM (Ki); Alpha-2B adrenergic receptor: 0.41 nM (Ki); Alpha-2A adrenergic receptor: 1.77 nM (Ki); Alpha-2C adrenergic receptor: 3.55 nM (Ki); Alpha-1B adrenergic receptor: 9.4 nM (Ki); Alpha-1A adrenergic receptor: 18.9 nM (Ki); Alpha-1D adrenergic receptor: 30.2 nM (Ki)
References
[1] Alexandre V Ivachtchenko, et al. AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53(2):583-620. DOI:10.3233/JAD-151146
AVN-101 Preparation Products And Raw materials
Raw materials
Preparation Products
AVN-101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai Zhen Li Biological Technology Co., Ltd | 021-16621358918; 18516310516;16621358918;13045646768 | zhenlipharma888@163.com | China | 19060 | 58 |
| Wuhan Sun-shine Bio-technology Corporation Limited | +86-027-6552-2453 | sales@sun-shinechem.com | China | 725 | 58 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
