AVN-492
- CAS No.
- 1220646-23-0
- Chemical Name:
- AVN-492
- Synonyms
- CS-2812;AVN-492;AVN-492, 10 mM in DMSO;AVN-492; AVN 492; AVN492;1220646-23-0;N2,N6,N6,5,7-Pentamethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine-2,6-diamine;3-(benzenesulfonyl)-N2,5,N6,N6,7-pentamethylpyrazolo[1,5-a]pyrimidine-2,6-diamine;Pyrazolo[1,5-a]pyrimidine-2,6-diamine, N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)-;inhibit,5-HT Receptor,Inhibitor,AVN-492,Serotonin Receptor,AVN 492,5-hydroxytryptamine Receptor
- CBNumber:
- CB53356145
- Molecular Formula:
- C17H21N5O2S
- Molecular Weight:
- 359.45
- MDL Number:
- MFCD31544338
- MOL File:
- 1220646-23-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility |
DMSO:62.5(Max Conc. mg/mL);173.88(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);69.55(Max Conc. mM) DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.11(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);2.78(Max Conc. mM) |
| form | A crystalline solid |
| pka | 1.04±0.30(Predicted) |
| color | White to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
AVN-492 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28079 | AVN-492 ≥98% | 1220646-23-0 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 28079 | AVN-492 ≥98% | 1220646-23-0 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 28079 | AVN-492 ≥98% | 1220646-23-0 | 10mg | $312 | 2026-04-30 | Buy |
| Cayman Chemical | 28079 | AVN-492 ≥98% | 1220646-23-0 | 25mg | $680 | 2026-04-30 | Buy |
| Biosynth | VYB64623 | AVN-492 | 1220646-23-0 | 25mg | $982.75 | 2026-06-05 | Buy |
AVN-492 Chemical Properties, Uses, Production
Uses
AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
in vivo
In rats, the plasma, brain, and CSF concentrations of the PO administered AVN-492 are dose-dependent. The drug concentration curves for the plasma and brain are of hyperbolic shape and at all doses the brain-plasma ratio is near 11%. The drug concentration in CSF, however, is nearly linearly dependent on the dose, reaching 50% of the plasma level at 10mg/kg. In mice, the plasma and brain concentrations of AVN-492, given IV at a dose of 2 mg/kg, decreased with time but at both time points, 15 min and 60 min, the brain/plasma ratio (mean±SEM) is nearly the same, at 13.2±0.7% and 9.0±1.5%, respectively. This indicates that the steady-state concentration gradient of AVN-492 is established by at least 15 min after the drug administration[1].
IC 50
5-HT6 Receptor: 91 pM (Ki)
References
[1] Ivachtchenko AV, et al. AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation. J Alzheimers Dis. 2017;58(4):1043-1063. DOI:10.3233/JAD-161262
AVN-492 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9773 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
