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3-Methylthio-1,2,4-triazine

3-Methylthio-1,2,4-triazine structure

CAS No.: 28735-21-9

Chemical Name:: 3-Methylthio-1,2,4-triazine

Synonyms: 3-(Methylthio)-as-Triazine;3-METHYLTHIO-1,2,4-TRIAZINE;3-(Methylthio)-2,4-triazine;1,2,4-Triazine, 3-(Methylthio)-;3-(Methylsulfanyl)-1,2,4-triazine;METHYL 1,2,4-TRIAZIN-3-YL SULFIDE;3-Methylthio-1,2,4-triazine ISO 9001：2015 REACH

CBNumber:: CB0317993

Molecular Formula:: C4H5N3S

Molecular Weight:: 127.17

MDL Number:: MFCD00490024

MOL File:: 28735-21-9.mol

MSDS File:: SDS

Last updated:2026-05-27 17:36:23

Product description	Number	Pack Size	Price
3-(Methylthio)-2,4-triazine	SYX00362	1g	$230
3-Methylthio-1,2,4-triazine >97%	OR961054	5g	$21
3-Methylthio-1,2,4-triazine >97%	OR961054	25g	$73
3-Methylthio-1,2,4-triazine >97%	OR961054	100g	$281
3-Methylthio-1,2,4-triazine >97%	OR961054	500g	$1374
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3-Methylthio-1,2,4-triazine Properties

Melting point	33 °C
Boiling point	275.8±23.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	solid
pka	1.32±0.63(Predicted)
Appearance	Yellow to brown <33°C Solid,>33°C Liquid
InChI	InChI=1S/C4H5N3S/c1-8-4-5-2-3-6-7-4/h2-3H,1H3
InChIKey	NFHGWQLAJYTULJ-UHFFFAOYSA-N
SMILES	N1C=CN=C(SC)N=1
CAS DataBase Reference	28735-21-9
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
WGK Germany	WGK 3
HS Code	2933698090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

3-Methylthio-1,2,4-triazine price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00362	3-(Methylthio)-2,4-triazine	28735-21-9	1g	$230	2026-04-30	Buy
Apolloscientific	OR961054	3-Methylthio-1,2,4-triazine >97%	28735-21-9	5g	$21	2026-06-04	Buy
Apolloscientific	OR961054	3-Methylthio-1,2,4-triazine >97%	28735-21-9	25g	$73	2026-06-04	Buy
Apolloscientific	OR961054	3-Methylthio-1,2,4-triazine >97%	28735-21-9	100g	$281	2026-06-04	Buy
Apolloscientific	OR961054	3-Methylthio-1,2,4-triazine >97%	28735-21-9	500g	$1374	2026-06-04	Buy

Product number	Packaging	Price	Buy
SYX00362	1g	$230	Buy
OR961054	5g	$21	Buy
OR961054	25g	$73	Buy
OR961054	100g	$281	Buy
OR961054	500g	$1374	Buy

3-Methylthio-1,2,4-triazine Chemical Properties,Uses,Production

Uses

3-Methylthio-1,2,4-triazine has a phenyl ring and has been shown to be pde5 inhibitory. 3-Methylthio-1,2,4-triazine was treated with potassium amide in liquid ammonia to give 3-amino-1,2,4-triazine, 3,3′-bis(methylthio)-5,5′-bis-1,2,4-triazine and 3-amino-3′-(methylthio)-5,5′-bis-1,2,4-triazine. triazine, 3,3′-bis(methylthio)-5,5′-bis-1,2,4-triazine and 3-amino-3′-(methylthio)-5,5′-bis-1,2,4-triazine. It is also used in the preparation of pharmaceutical products.

Synthesis

131543-46-9

S-METHYL ISOTHIOSEMICARBAZIDE HYDROIODIDE

35600-34-1

28735-21-9

The general procedure for the synthesis of 3-(methylthio)-α-triazine from 3-methylthioalkyl-1,2,4-triazine methylhydrazinylideneamino thiosulfate hydrogen iodide (Intermediate 16, 8.5 g, 32.18 mmol) and 40% oxalyl aldehyde (14.70 mL, 128.71 mmol) was as follows: an ice/water (400 mL) solution of Intermediate 16 was added to a 40% oxaldehyde solution with stirring. Subsequently, an ice/water (400 mL) solution of sodium bicarbonate (6.76 g, 80.45 mmol) cooled to 0°C was stirred at 0°C for 5 hours. After completion of the reaction, the reaction mixture was extracted with dichloromethane (DCM, 2 x 150 mL). The organic phases were combined, washed with 1 M citric acid (50 mL), dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure to afford 3-methylthioalkyl-1,2,4-triazine (3.60 g, 88% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3, 27 °C): δ 2.68 (3H, s), 8.38 (1H, d), 8.94 (1H, d).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 20, p. 6024 - 6029
[2] Tetrahedron Letters, 1986, vol. 27, # 4, p. 431 - 432
[3] Patent: US2017/152255, 2017, A1. Location in patent: Paragraph 0294; 0295
[4] Tetrahedron Letters, 1987, vol. 28, # 4, p. 379 - 382

3-Methylthio-1,2,4-triazine Preparation Products And Raw materials

Raw materials

6-methyl-3-methylsulfanyl-1,2,4-triazine 1,2-Ethenediylbis(oxy) (9CI) S-METHYL ISOTHIOSEMICARBAZIDE HYDROIODIDE Sodium bicarbonate

Preparation Products

1,2,4-Triazin-3-amine, N-butyl-

3-Methylthio-1,2,4-triazine Suppliers

Global( 117)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Tianjin Huiren Chemtech Co., Ltd	+86-86-22-23707858 +86-86-13672008665	huirentech@foxmail.com	China	171	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	287	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Tianjin Huiren Chemtech Co., Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hebei Jimi Trading Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 3-Methylthio-1,2,4-triazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-30	3-Methylthio-1,2,4-triazine 28735-21-9		1KG	95%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2026-03-20	3-Methylthio-1,2,4-triazine 28735-21-9	$9.90	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2019-12-23	3-Methylthio-1,2,4-triazine 28735-21-9	$1.00	100g	99%		Career Henan Chemical Co

3-Methylthio-1,2,4-triazine
28735-21-9
95%
Shenzhen Nexcon Pharmatechs Ltd.

3-Methylthio-1,2,4-triazine
28735-21-9
$9.90
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-Methylthio-1,2,4-triazine
28735-21-9
$1.00
99%
Career Henan Chemical Co

3-Methylthio-1,2,4-triazine Spectrum

3-Methylthio-1,2,4-triazine(28735-21-9)¹HNMR

28735-21-9(3-Methylthio-1,2,4-triazine)Related Search:

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METHYL 1,2,4-TRIAZIN-3-YL SULFIDE 3-(Methylsulfanyl)-1,2,4-triazine 1,2,4-Triazine, 3-(Methylthio)- 3-(Methylthio)-as-Triazine 3-(Methylthio)-2,4-triazine 3-METHYLTHIO-1,2,4-TRIAZINE 3-Methylthio-1,2,4-triazine ISO 9001：2015 REACH 28735-21-9