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AD80

AD80 structure

CAS No.: 1384071-99-1

Chemical Name:: AD80

Synonyms: AD80;AD80 ，S8518;Reaxys ID: 27131146;AD80, 10 mM in DMSO;Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src;1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea;1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea;Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-

CBNumber:: CB03310308

Molecular Formula:: C22H19F4N7O

Molecular Weight:: 473.43

MDL Number:: MFCD31382193

MOL File:: 1384071-99-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:37:21

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AD80 Properties

Boiling point	530.9±50.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO:122.0(Max Conc. mg/mL);257.69(Max Conc. mM) Ethanol:94.0(Max Conc. mg/mL);198.55(Max Conc. mM)
pka	12.47±0.70(Predicted)
form	Solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

AD80 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	JFC07199	AD80	1384071-99-1	25mg	$913.5	2026-06-04	Buy
Biosynth	JFC07199	AD80	1384071-99-1	50mg	$1370	2026-06-04	Buy
ChemScene	CS-6926	AD80 99.88%	1384071-99-1	5mg	$125	2026-06-04	Buy
ChemScene	CS-6926	AD80 99.88%	1384071-99-1	10mg	$200	2026-06-04	Buy
ChemScene	CS-6926	AD80 99.88%	1384071-99-1	25mg	$401	2026-06-04	Buy

Product number	Packaging	Price	Buy
JFC07199	25mg	$913.5	Buy
JFC07199	50mg	$1370	Buy
CS-6926	5mg	$125	Buy
CS-6926	10mg	$200	Buy
CS-6926	25mg	$401	Buy

AD80 Chemical Properties,Uses,Production

Uses

AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.

Biological Activity

AD80, a multi-kinase inhibitor, is more active against human RET (c-RET), BRAF, S6K, and SRC, but less active against mTOR than AD57 or AD58. Its IC50 value for RET (c-RET) is 4 nM.

in vivo

AD80 is a potent RET inhibitor with favorable pharmacokinetic profile in clinically relevant RET fusion-driven tumor models. In patient-derived xenograft species, AD80 effectively reduced RET-rearranged tumor size.

target

Target	Value
Raf (Cell-free)
Src < br/> (Cell-free)
S6 Kinase (Cell-free)
RET V804M (Cell-free assay)	0.4 nM
RET V804L (Cell-free assay)	0.6 nM

IC 50

p70S6K; RAF; RET; SRC

References

[1] Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.Nature. 2012 Jun 6;486(7401):80-4. DOI:10.1038/nature11127
[2] Liu H, et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Cell Rep. 2017 Feb 28;18(9):2088-2095. DOI:10.1016/j.celrep.2017.02.022

AD80 Preparation Products And Raw materials

Raw materials

Preparation Products

AD80 Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HangZhou YuHao Chemical Technology Co., Ltd.	0571-82693216	info@yuhaochemical.com	China	1999	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4860	55
Shanghaizehan biopharma technology co., Ltd.	021-61350663 13052117465	sales@zehanbiopharma.com	China	989	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2971	58
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Chuzhou KeMail Chemical Technology Co., Ltd	0550-5196001 15000891977	wj520wjxby@126.com	China	1940	55
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3307	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9718	58

Supplier	Advantage
HangZhou YuHao Chemical Technology Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghaizehan biopharma technology co., Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Rechem science Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Amadis Chemical Company Limited	58
Chuzhou KeMail Chemical Technology Co., Ltd	55
Angel Pharmatech, Ltd.	58
Fan De(Beijing) Biotechnology Co., Ltd.	58

AD80 Spectrum

AD80(1384071-99-1)¹HNMR

1384071-99-1(AD80)Related Search:

AD80 AD57 (hydrochloride) Urea, N-[4-[4-aMino-1-(1-Methylethyl)-1H-pyrazolo[3,4-d]pyriMidin-3-yl]phenyl]-N'-[3-(trifluoroMethyl)phenyl]- 1-(tert-Butyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine PLX4032

Pyridostatin hydrochloride

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AD80 1-(4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-methyl-5-(trifluoromethyl)phenyl)urea Reaxys ID: 27131146 Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]- 1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea Inhibitor,Raf,AD 80,inhibit,Raf kinases,AD-80,Ribosomal S6 Kinase (RSK),S6K,RET,AD80,Src AD80, 10 mM in DMSO AD80 ，S8518 1384071-99-1 C22H19F4N7O