6877002
- CAS No.
- 433249-94-6
- Chemical Name:
- 6877002
- Synonyms
- 6877002;Compound 6877002;TRAF-STOP 6877002;CD40-TRAF6 inhibitor;CD40-TRAF6 signaling inhibitor;CD40-TRAF6 Signaling Inhibitor, 6877002;TRAF-STOP inhibitor 6877002, 10 mM in DMSO;Compound 6877002, CD40-TRAF6 interaction inhibitor;3-((2,5-Dimethylphenyl)amino)-1-phenylprop-2-en-1-one;2-Propen-1-one, 3-[(2,5-dimethylphenyl)amino]-1-phenyl-
- CBNumber:
- CB03311729
- Molecular Formula:
- C17H17NO
- Molecular Weight:
- 251.32
- MDL Number:
- MOL File:
- 433249-94-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 378.6±42.0 °C(Predicted) |
|---|---|
| Density | 1.104±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 125 mg/mL (497.37 mM) |
| pka | 0.82±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChI | 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+ |
| InChIKey | WIFPLULEUNBSTE-GZTJUZNOSA-N |
| SMILES | O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
6877002 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1160 | CD40-TRAF6 signaling inhibitor ≥98% (HPLC) | 433249-94-6 | 5 mg | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1160 | CD40-TRAF6 signaling inhibitor ≥98% (HPLC) | 433249-94-6 | 25 mg | $356 | 2026-04-30 | Buy |
| Biosynth | ISA24994 | TRAF-STOP inhibitor 6877002 | 433249-94-6 | 100mg | $1128 | 2026-06-04 | Buy |
| ChemScene | CS-0033112 | TRAF-STOP inhibitor 6877002 99.67% | 433249-94-6 | 5mg | $60 | 2026-06-04 | Buy |
| ChemScene | CS-0033112 | TRAF-STOP inhibitor 6877002 99.67% | 433249-94-6 | 10mg | $82 | 2026-06-04 | Buy |
6877002 Chemical Properties,Uses,Production
Uses
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one functions as CD40-TRAF6 inhibitors. Inhibition of CD40 signalling pathway seems a better way to ameliorate inflammatory diseases, like the inflammation in models of peritonitis and sepsis.
Biological Activity
Cell permeable: yes', 'Primary Target
TRAF6
in vivo
TRAF-STOP inhibitor 6877002 (10 μmol/kg; intraperitoneal injection; once a day; 6 weeks) retards the development of early atherosclerosis and reduces atherosclerotic plaque area in apolipoprotein E-deficient (Apoe-/-) mice[1].
TRAF-STOP inhibitor 6877002 (10 μmol/kg; intraperitoneal injection; once a day; 6 weeks) halts the progression of established atherosclerosis, induces a stable plaque phenotype, reduces macrophage number and proliferation, decreases the size of necrotic cores, reduces the number of neutrophils and T cells, and increases collagen and αSMA+ smooth muscle cell content in atherosclerotic plaques in apolipoprotein E-deficient (Apoe-/-) mice[1].
TRAF-STOP inhibitor 6877002 (10 μmol/kg; administered via recombinant high-density lipoprotein nanoparticles; twice a week; 6 weeks) reduces plaque volume in the aortic root and the number of macrophages in plaques in apolipoprotein E-deficient (Apoe-/-) mice[1].
| Animal Model: | Male apolipoprotein E-deficient (Apoe-/-) mice (22 weeks old), with advanced atherosclerotic lesions already present in the aortic arch to establish an established atherosclerosis model[1]. |
| Dosage: | 10 μmol/kg (vehicle: PBS, 0.05% Tween 80, 5% dimethylsulfoxide) |
| Administration: | Intraperitoneal injection, once a day, for 6 weeks |
| Result: | Halted the progression of established atherosclerosis, reduced the total atherosclerotic plaque area in the aortic arch and aortic root. The atherosclerotic plaques exhibited a stable phenotype with decreased macrophage number and proliferation, smaller necrotic cores, fewer neutrophils and T cells, and increased collagen and αSMA+ smooth muscle cell content. |
| Animal Model: | Male apolipoprotein E-deficient (Apoe-/-) mice (12 weeks old), fed a normal chow diet to establish an atherosclerosis-prone model[1]. |
| Dosage: | 10 μmol/kg (vehicle: PBS, 0.05% Tween 80, 5% dimethylsulfoxide) |
| Administration: | Intraperitoneal injection, once a day, for 6 weeks |
| Result: | Retarded the development of early atherosclerosis, reduced atherosclerotic plaque area in the aortic arch, and the plaques contained fewer macrophages, T cells, and neutrophils. There were no changes in the number of proliferating or apoptotic cells, plaque smooth muscle cell or collagen content. |
| Animal Model: | Male apolipoprotein E-deficient (Apoe-/-) mice (12 weeks old) with atherosclerosis model[1]. |
| Dosage: | 10 μmol/kg (packaged in recombinant high-density lipoprotein nanoparticles) |
| Administration: | Administered via recombinant high-density lipoprotein nanoparticles, twice a week, for 6 weeks |
| Result: | Reduced plaque volume in the aortic root and the number of macrophages in plaques. |
storage
Store at +4°C
6877002 Preparation Products And Raw materials
Raw materials
Preparation Products
6877002 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
View Lastest Price from 6877002 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-08 | TRAF-STOP inhibitor 6877002
433249-94-6
|
$36.00-145.00 | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | CD40-TRAF6 inhibitor
433249-94-6
|
1KG | 98% | 20Tons | Shaanxi Dideu New Materials Co. Ltd |
-
- TRAF-STOP inhibitor 6877002
433249-94-6
- $36.00-145.00
- 99.76%
- TargetMol Chemicals Inc.
-
- CD40-TRAF6 inhibitor
433249-94-6
- 98%
- Shaanxi Dideu New Materials Co. Ltd
