ChemicalBook >> CAS DataBase List >>2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide

CAS No.
693793-82-7
Chemical Name:
2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
Synonyms
Atorvastatin calcium-19;Atorvastatin Impurity 5;Atorvastatin Impurity 24;Atorvastatin Impurity 178;2-(1,2-bis(4-fluorophenyl);Atorvastatin Difluoro Impurity;Atorvastatin calcium impurity 27;Atorvastatin Calcium Hydrate impurity 37;2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N-phenylpentanamide;2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
CBNumber:
CB03312504
Molecular Formula:
C26H23F2NO3
Molecular Weight:
435.46
MDL Number:
MFCD30181864
MOL File:
693793-82-7.mol
Last updated:2025-07-04 15:20:32

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Properties

Boiling point 633.7±55.0 °C(Predicted)
Density 1.248±0.06 g/cm3(Predicted)
pka 11.49±0.59(Predicted)
InChI InChI=1S/C26H23F2NO3/c1-16(2)24(30)23(26(32)29-21-6-4-3-5-7-21)22(17-8-12-19(27)13-9-17)25(31)18-10-14-20(28)15-11-18/h3-16,22-23H,1-2H3,(H,29,32)
InChIKey KUEDWDDLRXOHDM-UHFFFAOYSA-N
SMILES C(NC1=CC=CC=C1)(=O)C(C(C1=CC=C(F)C=C1)C(C1=CC=C(F)C=C1)=O)C(=O)C(C)C

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Chemical Properties,Uses,Production

Uses

4-Fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenylbenzenebutanamide is an intermediate in the synthesis of Difluoro Atorvastatin Acetonide tert-Butyl Ester (D445455), a useful synthetic intermediate in the synthesis of Difluoro Atorvastatin (D445660); an Atorvastatin impurity.

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Atorvastatin Impurity 24 2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N-phenylpentanamide Atorvastatin Impurity 5 Atorvastatin impurity 18/2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N- phenylpentanamide (3R,5R)-tert-butyl 7-(2-(2-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate Atorvastatin Calcium Hydrate impurity 37 2-(1,2-bis(4-fluorophenyl) Atorvastatin calcium-19 Benzenebutanamide, 4-fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenyl- Atorvastatin Impurity 178 4-Fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenylbenzenebutanamide Atorvastatin Difluoro Impurity Atorvastatin calcium impurity 27 693793-82-7 C26H23F2NO3