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CGP 42112

CGP 42112 structure

CAS No.: 127060-75-7

Chemical Name:: CGP 42112

Synonyms: CGP 42112;CGP-42112A;CGP 42112 TFA;CGP42112A, CGP42112;CGP-42112 (CGP42112;ANGIOTENSIN II ANTAGONIST;ANGIOTENSIN II RECEPTOR LIGAND;NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE;CGP 42112, AT2 receptor ligand;CGP-42112A >=95%, synthetic, solid

CBNumber:: CB0334084

Molecular Formula:: C52H69N13O11

Molecular Weight:: 1052.19

MDL Number:: MFCD00133611

MOL File:: 127060-75-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:28

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CGP 42112 Properties

Density	1.39±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM)
pka	3.72±0.22(Predicted)
form	solid
color	white
biological source	synthetic
Water Solubility	Soluble to 1 mg/ml in water
BRN	8184948
InChIKey	UXGNARZDONUMMK-LRMQDCNJSA-N
SMILES	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O
FDA UNII	9Q3V7W3XDD
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
F	10
Storage Class	11 - Combustible Solids

CGP 42112 price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C160	CGP-42112A ≥95%, synthetic, solid	127060-75-7	1mg	$302	2026-04-30	Buy
Sigma-Aldrich	C160	CGP-42112A ≥95%, synthetic, solid	127060-75-7	5mg	$1080	2026-04-30	Buy
Cayman Chemical	32874	CGP 42112 ≥98%	127060-75-7	1mg	$142	2026-04-30	Buy
Cayman Chemical	32874	CGP 42112 ≥98%	127060-75-7	5mg	$426	2026-04-30	Buy
Cayman Chemical	32874	CGP 42112 ≥98%	127060-75-7	10mg	$710	2026-04-30	Buy

Product number	Packaging	Price	Buy
C160	1mg	$302	Buy
C160	5mg	$1080	Buy
32874	1mg	$142	Buy
32874	5mg	$426	Buy
32874	10mg	$710	Buy

CGP 42112 Chemical Properties, Uses, Production

Uses

CGP-42112A has been used:

in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Definition

ChEBI: CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide.

Biochem/physiol Actions

Potent AT2 angiotensin II receptor agonist.

in vivo

Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF^[3].

IC 50

AT2 Receptor; AT1 Receptor

storage

Store at -20°C

CGP 42112 Preparation Products And Raw materials

Raw materials

Preparation Products

CGP 42112 Suppliers

Global Suppliers ( 102)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2374	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Creative Peptides		info@creative-peptides.com	United States	6083	56

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Haoyuan Chemexpress Co., Ltd.	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
LETOPHARM LIMITED	58
Sigma-Aldrich	80
Creative Peptides	56

View Latest Price from CGP 42112 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-14	CGP 42112 127060-75-7	$7.00	1KG	99%	100kg	Career Henan Chemical Co

CGP 42112
127060-75-7
$7.00
99%
Career Henan Chemical Co

127060-75-7 (CGP 42112) Related Search:

2-Phenyl-N-(pyridin-3-ylmethyl)ethanamine CGP 42112a, [125I]- CGP 42112a, [3-(125I)-Tyr] H-Pro-Val-OH H-Pro-Ile-OH

SG 1842 Lys-His-Gly-NH2 Glycylglycyl-L-isoleucine Phenatine CHEMBRDG-BB 5402672

CGP 42112 (2S)-1-[(2S)-2-Amino-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxamide CHEMBRDG-BB 9071485 (6-Aminohexyl)carbamic acid

1of3

[N-ALPHA-(NICOTINOYL-L-TYROSYL)-N-EPSILON-(N-ALPHA-Z-L-ARGINYL)-L-LYSYL]-L HISTIDYL-L-PROLYL-L-ISOLEUCINE N-ALPHA-NICOTINOYL-TYR-LYS(N-ALPHA-CBZ-ARG)-HIS-PRO-ILE N-ALPHA-NICOTINOYL-TYR-(N-ALPHA-CBZ-ARG)-LYS-HIS-PRO-ILE-OH NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE CGP 42112 CGP-42112A Angiotensin II Receptor Ligand Nicotinoyl-Tyr-Lys(Z-Arg)-His-Pro-Ile-OH ANGIOTENSIN II ANTAGONIST ANGIOTENSIN II RECEPTOR LIGAND CGP-42112A >98% SYNTHETIC (POTENTANGIOTE NSIN II TYPE A N-NICOTINOYL-TYR-N-EPSILON(NA-CBZ-ARG)-L YS-HIS-PRO nα-nicotinoyl-tyr-(nα-cbz-arg)-lys-his-pro-ile N6-[[(Phenylmethoxy)carbonyl]-L-Arg-]-N2-[[(pyridin-3-yl)carbonyl]-L-Tyr-]-L-Lys-L-His-L-Pro-L-Ile-OH CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE CGP42112A, CGP42112 CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A CGP-42112 (CGP42112 L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl- CGP-42112A >=95%, synthetic, solid (2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-Imidazol-5-yl)methyl)-5-(3-guanidinopropyl)-12-((S)-3-(4-hydroxyphenyl)-2-(nicotinamido)propanamido)-3,6,13-trioxo-1-phenyl-2-oxa-4,7,14-triazahexadecan-16-oyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid CGP 42112 TFA CGP 42112, AT2 receptor ligand 127060-75-7 C52H69N13O11 Biochemicals and Reagents Angiotensins Amino Acids and Peptides BioChemical Peptides