TCO-PEG4-NHS Ester
- CAS No.
- 1621096-79-4
- Chemical Name:
- TCO-PEG4-NHS Ester
- Synonyms
- TCO4-PEG4-NHS;(E)-TCO-PEG4-NHS ester;TCO-PEG4-NHS Ester (CCT-A137);TCO-PEG4-NHS Ester,Trans-Cyclooctene-PEG4-NHS ester;TCO-PEG4-NHS(contains 6% Dichloromethane at maximum);(E)-2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4E)-4-cycloocten-1-yl 17-(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber:
- CB03345120
- Molecular Formula:
- C24H38N2O10
- Molecular Weight:
- 514.57
- MDL Number:
- MOL File:
- 1621096-79-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H316-H371-H373-H341-H350-H412 |
| Precautionary statements | P501-P273-P260-P270-P202-P201-P264-P280-P308+P311-P332+P313-P405 |
TCO-PEG4-NHS Ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3949 | TCO-PEG4-NHS (contains 6% Dichloromethane at maximum) | 1621096-79-4 | 25MG | $492 | 2026-04-30 | Buy |
| Cayman Chemical | 44735 | TCO-PEG4-NHS ester ≥95% | 1621096-79-4 | 1mg | $25 | 2026-04-30 | Buy |
| Cayman Chemical | 44735 | TCO-PEG4-NHS ester ≥95% | 1621096-79-4 | 5mg | $56 | 2026-04-30 | Buy |
| Cayman Chemical | 44735 | TCO-PEG4-NHS ester ≥95% | 1621096-79-4 | 10mg | $88 | 2026-04-30 | Buy |
| Cayman Chemical | 44735 | TCO-PEG4-NHS ester ≥95% | 1621096-79-4 | 25mg | $188 | 2026-04-30 | Buy |
TCO-PEG4-NHS Ester Chemical Properties,Uses,Production
Description
TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).
The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.
The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.
Uses
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50
PEGs
References
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1013. DOI:10.1016/j.chembiol.2020.07.021
TCO-PEG4-NHS Ester Preparation Products And Raw materials
Raw materials
Preparation Products
TCO-PEG4-NHS Ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Zhengzhou Acme Chemical Co., Ltd. | 037163312495 13303845143 | 1416159398@qq.com | China | 10151 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Changsha Bono New Materials Technology Co., Ltd. | 18191076804 | asherw9@hotmail.com | China | 2373 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10778 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1881 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29676 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27963 | 58 |
| Vicbio Biotechnology Co., Ltd. | 13621190864 13691409741 | info@vicbio.com | China | 13147 | 58 |
