TCO-PEG3-acid
- CAS No.
- 2141981-86-2
- Chemical Name:
- TCO-PEG3-acid
- Synonyms
- TCO-PEG3-acid;TCO4-PEG3-COOH;(4E)-TCO-PEG3-acid;5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) ester;1-(Cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oic acid
- CBNumber:
- CB34849684
- Molecular Formula:
- C18H31NO7
- Molecular Weight:
- 373.44
- MDL Number:
- MFCD31811538
- MOL File:
- 2141981-86-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
TCO-PEG3-acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0114532 | TCO-PEG3-acid ≥98% | 2141981-86-2 | 50mg | $80 | 2026-06-04 | Buy |
| ChemScene | CS-0114532 | TCO-PEG3-acid ≥98% | 2141981-86-2 | 100mg | $136 | 2026-06-04 | Buy |
| ChemScene | CS-0114532 | TCO-PEG3-acid ≥98% | 2141981-86-2 | 250mg | $259 | 2026-06-04 | Buy |
| ChemScene | CS-0114532 | TCO-PEG3-acid ≥98% | 2141981-86-2 | 1g | $690 | 2026-06-04 | Buy |
| BroadPharm | bp-24143 | TCO-PEG3-acid 95% | 2141981-86-2 | 25MG | $180 | 2026-05-24 | Buy |
TCO-PEG3-acid Chemical Properties, Uses, Production
Description
TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(CO2H) group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. This reagent can react with tetrazine-containing compounds to form a stable covalent bond. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.
Uses
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50
PEGs
References
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001
TCO-PEG3-acid Preparation Products And Raw materials
Raw materials
Preparation Products
TCO-PEG3-acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | sean.lv@synzest.com | China | 10778 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | 133-31922809 19372841038 | lixing@pharmahuici.com | China | 853 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
