AX-024 hcl
- CAS No.
- 1370544-73-2
- Chemical Name:
- AX-024 hcl
- Synonyms
- CS-2619;AX-024 hcl;AX 024;AX024;1-((4-(4-FLUOROPHENYL)-6-METHOXY-2H-CHROMEN-3-YL)METHYL)PYRROLIDINE;Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-
- CBNumber:
- CB03357970
- Molecular Formula:
- C21H22FNO2
- Molecular Weight:
- 339.4
- MDL Number:
- MOL File:
- 1370544-73-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 452.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:35.0(Max Conc. mg/mL);103.12(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);294.63(Max Conc. mM) |
| pka | 9.26±0.20(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
AX-024 hcl price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VEC54473 | AX-024 | 1370544-73-2 | 25mg | $1260.75 | 2026-06-05 | Buy |
| Biosynth | VEC54473 | AX-024 | 1370544-73-2 | 50mg | $1754 | 2026-06-05 | Buy |
| ChemScene | CS-8052 | AX-024 99.73% | 1370544-73-2 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-8052 | AX-024 99.73% | 1370544-73-2 | 10mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-8052 | AX-024 99.73% | 1370544-73-2 | 25mg | $206 | 2026-06-04 | Buy |
AX-024 hcl Chemical Properties, Uses, Production
Description
AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation. AX-024 modulates cell signaling by targeting SH3 domains and has low-acute toxicity and high potency and selectivity in the inhibition of the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
Uses
AX-024, is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. It is a cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
in vitro
AX-024 reduces T cell proliferation upon weak T cell receptor (TCR) stimulation but neither significantly affects phosphorylation of Zap70 (ζ chain of T cell receptor–associated protein kinase 70) nor interacts directly with Nck1-SH3. AX-024 is likely not involved in modulating the Nck/TCR interaction but probably has other targets in T cells. An array of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 in vitro._x000D_ _x000D_ Reference: J Biol Chem. 2020 Jun 5;295(23):7849-7864. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278359/#B11
in vivo
AX-024-treated group presents less scales and reduces skin thickening compare to the vehicle group. AX-024 significantly reduces thickening of both skin layers, but more effectively of the dermis, which rather resembles that of mice treated with a control cream lacking imiquimod (IMQ). AX-024 significantly diminishes the number of airway inflammatory cells in both assays. Mice receiving AX-024 rapidly recovers from neurological impairment and weight loss, becoming symptom-free by day 30, unlike mice that receives the vehicle, in which ataxia and loss of the righting reflex persist[1].
target
AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
IC 50
IL-6; IL-10; IL-17A
AX-024 hcl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4866 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2728 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | dexuanyiyao@126.com | dexuanyiyao@126.com | China | 9470 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
