BTSA 1
- CAS No.
- 314761-14-3
- Chemical Name:
- BTSA 1
- Synonyms
- BTSA 1;CS-2853;BTSA1 ，S8650;BTSA 1;BTSA-1;BTSA1 >=98% (HPLC);BTSA1, 10 mM in DMSO;1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone];5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one;5-Phenyl-2-(4-phenylthiazol-2-yl)-4-(2-(thiazol-2-yl)hydrazono)-2,4-dihydro-3H-pyrazol-3-one;inhibit,FITC-BIM,caspase-3/7,translocation,Bcl-2 Family,viability,Inhibitor,BTSA1,mitochondrial,pharmacologically,BAX,AML,BTSA 1,BTSA-1,SAHBA2,Apoptosis
- CBNumber:
- CB03374627
- Molecular Formula:
- C21H14N6OS2
- Molecular Weight:
- 430.51
- MDL Number:
- MOL File:
- 314761-14-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 625.2±48.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM) |
| pka | 6.52±0.40(Predicted) |
| form | Solid |
| color | Brown to reddish brown |
| InChI | InChI=1S/C21H14N6OS2/c28-19-18(24-25-20-22-11-12-29-20)17(15-9-5-2-6-10-15)26-27(19)21-23-16(13-30-21)14-7-3-1-4-8-14/h1-13H,(H,22,25) |
| InChIKey | KYVZVVOQWWCVPP-UHFFFAOYSA-N |
| SMILES | N1(C2=NC(C3=CC=CC=C3)=CS2)C(=O)C(=NNC2=NC=CS2)C(C2=CC=CC=C2)=N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
BTSA 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2243 | BTSA1 ≥98% (HPLC) | 314761-14-3 | 5 mg | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2243 | BTSA1 ≥98% (HPLC) | 314761-14-3 | 25 mg | $362 | 2026-04-30 | Buy |
| Cayman Chemical | 37305 | BTSA1 ≥98% | 314761-14-3 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 37305 | BTSA1 ≥98% | 314761-14-3 | 10mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 37305 | BTSA1 ≥98% | 314761-14-3 | 25mg | $267 | 2026-04-30 | Buy |
BTSA 1 Chemical Properties, Uses, Production
Uses
BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
Biological Activity
BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells.
in vivo
BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated.
target
| Target | Value | ||||
| Bax () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2959 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4858 | 55 | |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| Hui Chem Co., Ltd. | 021-34799779 18918539052 | 1879902218@qq.com | China | 77 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
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