3-Aminobenzeneboronic acid hemisulfate salt
- CAS No.
- 66472-86-4
- Chemical Name:
- 3-Aminobenzeneboronic acid hemisulfate salt
- Synonyms
- 3-AMINOPHENYLBORONIC ACID HEMISULFATE;M-APBA;SKL266;3-Aminobenzeneboroni;boronic acid hemisuL;M-AMINOPHENYLBORIC ACID HEMISULFATE;(3-aminophenyl)-boronic aci sulfate;aminophenylboronic acid hemisulfate;3-aminophenylboric acid hemisulphate;M-AMINOPHENYLBORONIC ACID HEMISULFATE
- CBNumber:
- CB0357728
- Molecular Formula:
- C12H18B2N2O8S
- Molecular Weight:
- 371.96692
- MDL Number:
- MFCD00013111
- MOL File:
- 66472-86-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ≥300 °C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| Water Solubility | Soluble in water |
| form | Crystalline Powder |
| color | White to slightly beige |
| Sensitive | Hygroscopic |
| BRN | 8094151 |
| InChI | 1S/2C6H8BNO2.H2O4S/c2*8-6-3-1-2-5(4-6)7(9)10;1-5(2,3)4/h2*1-4,9-10H,8H2;(H2,1,2,3,4) |
| InChIKey | XMVGYYBQCXVVHU-UHFFFAOYSA-N |
| SMILES | OS(O)(=O)=O.Nc1cccc(c1)B(O)O.Nc2cccc(c2)B(O)O |
| CAS DataBase Reference | 66472-86-4 |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
3-Aminobenzeneboronic acid hemisulfate salt price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A71751 | 3-Aminophenylboronic acid hemisulfate salt ≥95% | 66472-86-4 | 5g | $149 | 2026-04-30 | Buy |
| Sigma-Aldrich | A71751 | 3-Aminophenylboronic acid hemisulfate salt ≥95% | 66472-86-4 | 25g | $484 | 2026-04-30 | Buy |
| TCI Chemical | A1774 | 3-Aminophenylboronic Acid Hemisulfate | 66472-86-4 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | A1774 | 3-Aminophenylboronic Acid Hemisulfate | 66472-86-4 | 5g | $81 | 2026-04-30 | Buy |
| Usbiological | 260061 | 3-Aminophenylboronic acid hemisulphate Asreported | 66472-86-4 | 2g | $333 | 2026-06-03 | Buy |
3-Aminobenzeneboronic acid hemisulfate salt Chemical Properties, Uses, Production
Chemical Properties
White to slightly beige crystalline powder
Uses
3-Aminobenzeneboronic acid hemisulfate salt is a boronic acid derivative, which can be used as an intermediate in pharmaceutical synthesis. Adsorbent additive for the chromatographic separation of 3'-terminal polynucleotides from RNA.
Application
3-Aminophenylboronic acid hemisulfate salt is used in the synthesis of:
Phenylboronic acid-functionalized inverse opal hydrogels within microfluidic flow cells for glucose sensing.
Phenylboronic acid-salicylhydroxamic acid-derived complexing reagent for protein immobilization on chromatographic support.
It can also be used in the preparation of phenylboronic acid (PBA) monolayer-modified Au electrode for the voltammetric sensing of uridine and cytidine.
Preparation
3-Aminobenzeneboronic acid hemisulfate salt synthesis: Benzenamine, 3-bromo-N-(diphenylmethylene)- (80,0 g; 0.24 moles) was added to the cryogenic reactor along with 1.4 equivalents of triisopropyl borate and dissolved in tetrahydrofuran. The resulting solution was cooled to -80°C under an inert atmosphere and 1.35 equivalents of n-butyllithium (as a solution in n-hexane) was added maintaining the internal temperature. When complete conversion was achieved, the reaction mixture was added to a dilute mixture of sulfuric acid (1 M) and toluene. The layers were separated to obtain an aqueous solution of 3-aminophenylboronic acid hydrogen sulfate (assay yield: 85%). 3-Aminobenzeneboronic acid hemisulfate salt can be obtained by precipitating a 0.5 M aqueous solution at pH 7.2 (pH corrected with 33% aqueous NaOH) at a temperature of 0-5°C. Filtration and drying under vacuum at 40°C for 8 hours yielded 21.7 g of 3-Aminobenzeneboronic acid hemisulfate salt (0.16 moles; 66% molar yield).
3-Aminobenzeneboronic acid hemisulfate salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 3-Aminobenzeneboronic acid hemisulfate salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-05-23 | 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-04 | 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 3-Aminobenzeneboronic acid hemisulfate salt
66472-86-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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