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BISPYRAZOLONE

BISPYRAZOLONE structure

CAS No.: 7477-67-0

Chemical Name:: BISPYRAZOLONE

Synonyms: NSC 37393;NSC 401001;BISPYRAZOLONE;edaravone diMer;Bispyrazolone, GR;Bispyrazolone, 98+%;Edaravone impurity Ⅰ;Edaravone IMpurity IV;LABOTEST-BB LT00008461;Edaravone DiMer IMpurity

CBNumber:: CB0360601

Molecular Formula:: C20H18N4O2

Molecular Weight:: 346.38

MDL Number:: MFCD00020765

MOL File:: 7477-67-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:39:02

Product description	Number	Pack Size	Price
Bispyrazolone for TLC derivatization, for the det.of cyanide, ≥98.0%	15156	5g	$56.2
Bis(3-methyl-1-phenyl-5-pyrazolone) [for Determination of CN, Vitamin B12, etc] >97.0%(T)	B0508	25g	$103
Bis(3-methyl-1-phenyl-5-pyrazolone) [for Determination of CN, Vitamin B12, etc] >97.0%(T)	B0508	250g	$570
Bis(3-methyl-1-phenyl-5-pyrazolone)	FB75456	5g	$900
Bis(3-methyl-1-phenyl-5-pyrazolone)	FB75456	2g	$900
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BISPYRAZOLONE Properties

Melting point	355 °C
Boiling point	481.12°C (rough estimate)
Density	1.31
refractive index	1.6620 (estimate)
storage temp.	Refrigerator
solubility	formic acid: 50 mg/mL, clear, yellow
pka	2.15±0.70(Predicted)
form	crystalline
color	tan
BRN	572787
InChI	1S/C20H18N4O2/c1-13-17(19(25)23(21-13)15-9-5-3-6-10-15)18-14(2)22-24(20(18)26)16-11-7-4-8-12-16/h3-12,17-18H,1-2H3
InChIKey	FORCWSNQDMPPOC-UHFFFAOYSA-N
SMILES	CC1=NN(c2ccccc2)C(=O)C1C3C(C)=NN(c4ccccc4)C3=O
CAS DataBase Reference	7477-67-0(CAS DataBase Reference)
FDA UNII	P77NZ4BRC7
EPA Substance Registry System	[4,4'-Bi-3H-pyrazole]-3,3'-dione, 2,2',4,4'-tetrahydro-5,5'-dimethyl-2,2'-diphenyl- (7477-67-0)
UNSPSC Code	41116105
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317

Precautionary statements

P280g-P302+P352a-P321-P333+P313-P501a-P261-P272-P280-P302+P352+P333+P313+P363-P501

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

TSCA

TSCA listed

HS Code

29331990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

BISPYRAZOLONE price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15156	Bispyrazolone for TLC derivatization, for the det.of cyanide, ≥98.0%	7477-67-0	5g	$56.2	2026-04-30	Buy
TCI Chemical	B0508	Bis(3-methyl-1-phenyl-5-pyrazolone) [for Determination of CN, Vitamin B12, etc] >97.0%(T)	7477-67-0	25g	$103	2026-04-30	Buy
TCI Chemical	B0508	Bis(3-methyl-1-phenyl-5-pyrazolone) [for Determination of CN, Vitamin B12, etc] >97.0%(T)	7477-67-0	250g	$570	2026-04-30	Buy
Biosynth	FB75456	Bis(3-methyl-1-phenyl-5-pyrazolone)	7477-67-0	5g	$900	2026-06-04	Buy
Biosynth	FB75456	Bis(3-methyl-1-phenyl-5-pyrazolone)	7477-67-0	2g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
15156	5g	$56.2	Buy
B0508	25g	$103	Buy
B0508	250g	$570	Buy
FB75456	5g	$900	Buy
FB75456	2g	$900	Buy

BISPYRAZOLONE Chemical Properties,Uses,Production

Chemical Properties

off-white to cream-yellowish crystalline powder

Uses

Bispyrazolone is an impurity of Edaravone (E335000).

Uses

It is applied as a reagent for the detection and determination of cyanide. It is also used in an experimental procedure, done in order to remove linamarin in starch from cassava roots, by using plant cell wall-degrading enzymes, xylanase and cellulase. It was also used for spectrophotometric determination and quantization of urea in urine samples. It is also used in assay of cyanogenic compounds and determination of ammonia.

BISPYRAZOLONE synthesis

Synthesis of BISPYRAZOLONE from 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

BISPYRAZOLONE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate N-Bromosuccinimide Sodium acetate trihydrate Acetic acid Phenylhydrazine

1H-Pyrazol-5-ol, 3-methyl-4-nitroso-1-phenyl- 4-bromo-3-methyl-1-phenyl-pyrazolin-5-one Edaravone 1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one Ethanol

Selenium dioxide 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

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Preparation Products

4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-1,2-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one

BISPYRAZOLONE Suppliers

Global( 187)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
career henan chemical co	58
Standardpharm Co. Ltd.	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from BISPYRAZOLONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-08	Bispyrazolone 7477-67-0	$39.00-118.00		99.40%	10g	TargetMol Chemicals Inc.
2026-05-08	Bispyrazolone 7477-67-0	$39.00-118.00		99.40%	10g	TargetMol Chemicals Inc.
2025-06-27	BISPYRAZOLONE 7477-67-0		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

Bispyrazolone
7477-67-0
$39.00-118.00
99.40%
TargetMol Chemicals Inc.

Bispyrazolone
7477-67-0
$39.00-118.00
99.40%
TargetMol Chemicals Inc.

BISPYRAZOLONE
7477-67-0
99%
Hebei Chuanghai Biotechnology Co., Ltd

BISPYRAZOLONE Spectrum

BISPYRAZOLONE(7477-67-0)MS BISPYRAZOLONE(7477-67-0)IR1 BISPYRAZOLONE(7477-67-0)IR2 BISPYRAZOLONE(7477-67-0)Raman

7477-67-0(BISPYRAZOLONE)Related Search:

1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 1H-Pyrazole, 5-methoxy-3-methyl-1-phenyl- Acetyl ketene Edaravone Impurity 14 Edaravone Impurity 26

Edaravone Impurity 5 Edaravone Impurity 8 ethyl 3-acetoxy-2-butenoate Edaravone Impurity 15 Edaravone Impurity 19

1H-Pyrazole,3-ethoxy-5-methyl-1-phenyl-(9CI) Edaravone Impurity 6 NSC4751 Edaravone 5-Oxo-1-phenyl-2-pyrazolin-3-carboxylic acid

benzenediazonium chloride 4,5-Dihydro-α,3-diMethyl-5-oxo-1-phenyl-α-sulfo-1H-pyrazole-4-acetic Acid Edaravone Impurity 11

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BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE) BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE) BISPYRAZOLONE LABOTEST-BB LT00008461 4,4'-BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE) 4,4'-BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE) 3,3-DIMETHYL-1,1-DIPHENYL-(4,4-BI-2-PYRAZOLINE)-5,5-DIONE 3,3'-DIMETHYL-1,1'-DIPHENYL-[4,4'-BI-2-PYRAZOLINE]-5,5'-DIONE 3,3'-DIMETHYL-1,1'-DIPHENYL-4,4'-BI(5-PYRAZOLONE) 3,3'-DIMETHYL-1,1'-DIPHENYL-[4,4'-BIS-2-PYRAZOLINE]-5,5'-DIONE 3,3'-DIMETHYL-1,1'-DIPHENYL-4,4'-DI-2-PYRAZOLINE-5,5'-DIONE [4,4’-bi-3h-pyrazole]-3,3’-dione,2,2’,4,4’-tetrahydro-5,5’-dimethyl-2,2’-diphe Edaravone Impurity 16 (Bis-pyrazolone) 4,4'-Bis(1-phenyl-3-methyl-5-pyrazolone/3,3'-Dimethyl-1,1'-diphenyl[4,4'-bi-1H-pyrazole] Edaravone Impurity Ⅰ:2,2',4,4'-Tetrahydro-5,5'-dimethyl-2,2'-diphenyl-[4,4'-Bi-3H-pyrazole]-3,3'-dione [4,4’-bi-3H-Pyrazole]-3,3’-dione,2,2’,4,4’-tetrahydro-5,5’-dimethyl-2,2’-diphenyl- 4’-bi-3H-Pyrazole]-3,3’-dione,2,2’,4,4’-tetrahydro-5,5’-dimethyl-2,2’-diphenyl-[4 Bis(1-phenyl-3-methyl-5-pyrazo BISPYRAZOLONE, FOR THE DETECTION OF CYAN IDE 4,4'-BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE)[FOR DETERMINATION OF CN, VITAMIN B12, ETC] 97+% BISPYRAZOLONE(4,4''-BIS-(3-METHYL-1-PHENYL-5-PYRAZOLONE)) 2,2',4,4'-tetrahydro-5,5'-dimethyl-2,2'-diphenyl-[4,4'-bi-3H-Pyrazole]-3,3'-dione 3,3-DIMETHYL-1,1''-DIPHENYL[4,4''-BI-2-PYRAZOLINE]-5,5''-DIONE 98% 3,3'-Dimethyl-1,1'-diphenyl-4,4'-bi(2-pyrazolin-5-one) 3,3'-Dimethyl-1,1'-diphenyl[4,4'-bi-2-pyrazoline]-5,5'-dione,98% Bispyrazolone,3,3′-Dimethyl-1,1′-diphenyl-(4,4′-bi-2-pyrazoline)-5,5′-dione Bispyrazolone, 98+% Bis(3-Methyl-1-phenylpyrazol-5-one) NSC 37393 NSC 401001 Bispyrazolone 3,3'-Dimethyl-1,1'-diphenyl-4,4'-bi(5-pyrazolone) [for DeterMination of CN, VitaMin B12, etc] Bis(3-Methyl-1-phenyl-5-pyrazolone) edaravone diMer edaravone related substance A Edaravone DiMer IMpurity 3,3'-diMethyl-1,1'-diphenyl-1H,1'H-[4,4'-bipyrazole]-5,5'(4H,4'H)-dione 4,4'-Bis(3-Methyl-1-phenyl-5-pyrazolone), for analysis Edaravone IMpurity IV Bis(3-methyl-1-phenyl-5-pyrazolone) [for Determination of CN, Vitamin B12, etc] 3,3'-Dimethyl-1,1'-diphenyl[4,4'-bi-2-pyrazoline]-5,5'-dione Bis-pyrazolone Bis(3-methyl-1-phenyl-5-pyrazolone) 4,4'-Bis(3-methyl-1-phenyl-5-pyrazolone), 97%, for analysis Edaravone Impurity IV (Bispyrazolone) Bis(3-methyl-1-phenyl-5-pyrazolone)[forDeterminationofCN,VitaminB12,etc]> Bispyrazolone, GR Edaravone Impurity Ⅰ:2,2’,4,4’-Tetrahydro-5,5’-dimethyl-2,2’-diphenyl-[4,4’-Bi-3H-pyrazole]-3,3’-dione 5-methyl-4-(3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-yl)-2-phenyl-4H-pyrazol-3-one Bispyrazolone, Technical, Fisher Chemical Bis(3-methyl-1-phenyl-5-pyrazolone), for Determination of CN, Vitamin B12, etc，≥ 97.0% 3,3’-Dimethyl-1,1’-diphenyl-[4,4’-bi-2-pyrazoline]-5,5’-dione 4,4’-Bis(1-phenyl-3-methyl-5-pyrazolone/3,3’-Dimethyl-1,1’-diphenyl[4,4’-bi-1H-pyrazole Edaravone impurity Ⅰ 3,3'-Dimethyl-1,1'-diphenyl-1H,1'H-[4,4'-bipyrazole]-5,5'(4H,4'H)-dione (Edaravone Impurity) 3,3'-dimethyl-1,1'-diphenyl-4,4'-bi-5-pyrazolone Bispyrazolone, 10 mM in DMSO 3,3'-Dimethyl-1,1'-diphenyl-1H,1'H-[4,4'-bipyrazole]-5,5'(4H,4'H)-dione (Edaravone Impurity) Edaravone Dimer: 5,5'-Dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione 7477-67-0