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Arg-Gly-Asp

Arg-Gly-Asp Structure
Arg-Gly-Asp structure
CAS No.
99896-85-2
Chemical Name:
Arg-Gly-Asp
Synonyms
RGD;ARG-GLY-ASP PEPTIDE;F-336;H2N-RGD-OH;ARG-GLY-AS;Arg-Gly-Asp;L-ARG-GLY-ASP;H-ARG-GLY-ASP-OH;RGD (Arg-Gly-Asp);Arg-Gly-Asp (TLC)
CBNumber:
CB0364876
Molecular Formula:
C12H22N6O6
Molecular Weight:
346.34
MDL Number:
MFCD00057952
MOL File:
99896-85-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:19
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Arg-Gly-Asp Properties

Melting point 153-155℃ (ethyl ether )
Density 1.61±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in 0.1N acetic acid at 20mg/ml
pka 2.85±0.10(Predicted)
form Powder
color White to off-white
biological source synthetic
Water Solubility Soluble to 12 mg/mL (34.64 mM) in Water
Sequence Arg-Gly-Asp
InChI 1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
InChIKey IYMAXBFPHPZYIK-BQBZGAKWSA-N
SMILES C(O)(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)N
FDA UNII 78VO7F77PN
UNSPSC Code 12352209
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

Arg-Gly-Asp price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8052 Arg-Gly-Asp ≥97% (TLC) 99896-85-2 1mg $40 2026-04-30 Buy
Sigma-Aldrich A8052 Arg-Gly-Asp ≥97% (TLC) 99896-85-2 5mg $117 2026-04-30 Buy
Usbiological 260168 Arg-Gly-Asp 99896-85-2 50mg $305 2026-06-03 Buy
Usbiological 260168 Arg-Gly-Asp 99896-85-2 100mg $403 2026-06-03 Buy
Usbiological 260168 Arg-Gly-Asp 99896-85-2 250mg $566 2026-06-03 Buy
Product number Packaging Price Buy
A8052 1mg $40 Buy
A8052 5mg $117 Buy
260168 50mg $305 Buy
260168 100mg $403 Buy
260168 250mg $566 Buy

Arg-Gly-Asp Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Arg-Gly-Asp has been used:

  • to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
  • in adhesion assay
  • in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
  • in textile fabrication and RGD textile functionalization
  • to engineer a population of human dermal fibroblasts with impaired migration
  • to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
  • in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

target

integrin-ligand interaction

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

Arg-Gly-Asp Preparation Products And Raw materials

Raw materials

Preparation Products

Arg-Gly-Asp Suppliers

Global( 236)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd 18020125070 sales002@jszkhy.com China 2105 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Supplier Advantage
Hangzhou Peptidego Biotech Co.,Ltd. 58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Beijing HwrkChemical Technology Co., Ltd 55
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65

View Lastest Price from Arg-Gly-Asp manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Arginyl-glycyl-aspartic acid pictures 2026-08-25 Arginyl-glycyl-aspartic acid
99896-85-2
 $90.00-900.00 1KG 0.98 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
Arginine-glycine-aspartic acid pictures 2026-07-27 Arginine-glycine-aspartic acid
99896-85-2
 $54.00-155.00 99.94% 10g TargetMol Chemicals Inc.
ARG-GLY-ASP pictures 2025-06-25 ARG-GLY-ASP
99896-85-2
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
  • ARG-GLY-ASP pictures
  • ARG-GLY-ASP
    99896-85-2
  • $1.10
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd

Arg-Gly-Asp Spectrum

ARG-GLY-ASP(99896-85-2)MSARG-GLY-ASP(99896-85-2)1HNMR

99896-85-2(Arg-Gly-Asp)Related Search:

L-Glutamic acid, N-(N-L-arginylglycyl)- H-ARG-GLY-ASP-VAL-OH Gly-Arg-Gly-Asp-Ser-Pro-Lys Thymopoietin II (32-34) Arg-Gly-Asp-Ser
GRGDTP GRGDNP GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH KL-1
Arg-Gly-Asp Gly-Arg-Gly-Asp-Ser Arg-Leu-Arg-Phe-Asp Acdcrgdcfcg (disulfide bridge: 2-10 and 4-8) Trp-Asn-Arg-Gln-Leu-Tyr-Pro-Glu-Trp-Thr-Glu-Ala-Gln-Arg-Leu-Asp
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H2N-RGD-OH H-ARG-GLY-ASP-OH L-ARG-GLY-ASP ARGINYL-GLYCYL-ASPARTIC ACID Arg-Gly-Asp acetate Arginyl-glycyl-asparagilin F-336 L-Aspartic acid, N-(N-L-arginylglycyl)- N-(N-L-Arginylglycyl)-L-aspartic acid Rgd tripeptide sequence RGD (Arg-Gly-Asp) Peptides Arginyl - glycyl - aspartate L-Arginylglycyl-L-aspartic acid RGD PEPTIDE (CORE) L-Aspartic acid, L-arginylglycyl- H-Arg-Gly-Asp-OH≥ 98% (HPLC) Arg-Gly-Asp, ≥97% (HPLC) Arg-Gly-Asp >=97% (TLC) ARG-GLY-ASP USP/EP/BP (S)-2-(2-((S)-2-Amino-5-guanidinopentanamido)acetamido)succinic acid RGD (Arg-Gly-Asp) Arg-Gly-Asp (TLC) Integrin,RGD,inhibit,Inhibitor Arginine-glycine-aspartic acid RGD (Arg-Gly-Asp), sequence involved in cell adhesion L-Arginylglycyl-L-aspartic acid trifluroacetate ARG-GLY-AS ARG-GLY-ASP PEPTIDE RGD Arg-Gly-Asp 99896-85-2 C12H22N6O6 Cell Biology Cell Signaling and Neuroscience Extracellular Matrix Extracellular Matrix Peptides and Proteins Cytoskeleton and Extracellular Matrix BioChemical Peptide Cell Signaling Enzymes ECM ProteinsCytoskeleton and Extracellular Matrix Extracellular Matrix Extracellular Matrix Peptides (ECM) Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology Fibronectin Fragments and Analogs Matrix Metalloproteinases Products Various Peptides