4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile
- CAS No.
- 1669444-50-1
- Chemical Name:
- 4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile
- Synonyms
- PF-05214030;4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile;Benzonitrile, 4-[[1-[(2,4-dichlorophenyl)sulfonyl]-3-hydroxy-3-azetidinyl]methoxy]-2-fluoro-
- CBNumber:
- CB03692833
- Molecular Formula:
- C17H13Cl2FN2O4S
- Molecular Weight:
- 431.27
- MDL Number:
- MFCD30470490
- MOL File:
- 1669444-50-1.mol
- MSDS File:
- SDS
4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1010720 | PF-05214030 99.81% | 1669444-50-1 | 5mg | $173 | 2026-06-04 | Buy |
| Biosynth | BP180194 | PF 05214030 | 1669444-50-1 | 1mg | $415.94 | 2026-06-04 | Buy |
| ChemScene | CS-1010720 | PF-05214030 99.81% | 1669444-50-1 | 10mg | $294 | 2026-06-04 | Buy |
| Biosynth | BP180194 | PF 05214030 | 1669444-50-1 | 2mg | $665.5 | 2026-06-04 | Buy |
| ChemScene | CS-1010720 | PF-05214030 99.81% | 1669444-50-1 | 25mg | $587 | 2026-06-04 | Buy |
4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile Chemical Properties, Uses, Production
Description
PF-05214030 is a novel potent TRPV4 antagonist (hTRPV4 IC50 4nM; rTRPV4 IC50 27nM).
Uses
PF-05214030 is a TRPV4 antagonist (IC50: 4 and 27nM for hTRPV4 and rTRPV4 respectively). PF-05214030 reverses the reduction in bladder capacity caused by intravesical infusion of a TRPV4 agonist[1][2].
References
[1] Jiang Y, et al. Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. J Hematol Oncol. 2022 Mar 24;15(1):34. DOI:10.1186/s13045-022-01252-0
[2] Sarah Skerratt, et al. The Discovery and Optimisation of a Highly Selective Series of TRPV4 Antagonists.
4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Struchem CO.,LTD | 86-512-63009836 | sales@struchem.com | China | 87 | 60 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3968 | 60 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Struchem CO.,LTD | 60 |
| Struchem Co., Ltd. | 60 |
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from 4-((1-((2,4-dichlorophenyl)sulfonyl)-3-hydroxyazetidin-3-yl)methoxy)-2-fluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | PF-05214030
1669444-50-1
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- PF-05214030
1669444-50-1
- $1520.00-2500.00
- TargetMol Chemicals Inc.
