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Lercanidipine hydrochloride

Lercanidipine hydrochloride Structure
Lercanidipine hydrochloride structure
CAS No.
132866-11-6
Chemical Name:
Lercanidipine hydrochloride
Synonyms
LERCANIDIPINE HCL;Lercanidipine hydrochloride heMihydrate;CLAP;mE10;R 75;BCL10;c-E10;CIPER;IMD37;CarMen
CBNumber:
CB0371085
Molecular Formula:
C36H42ClN3O6
Molecular Weight:
648.19
MDL Number:
MFCD07773089
MOL File:
132866-11-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Lercanidipine hydrochloride Properties

Melting point 175-177°C
storage temp. 2-8°C
solubility soluble in Methanol
form powder
color yellow
Merck 14,5446
InChIKey WMFYOYKPJLRMJI-UHFFFAOYSA-N
SMILES C1(C)NC(C)=C(C(OC(C)(C)CN(CCC(C2=CC=CC=C2)C2=CC=CC=C2)C)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl
CAS DataBase Reference 132866-11-6(CAS DataBase Reference)
FDA UNII OA8TFX68PE
UNSPSC Code 12352200
NACRES NA.77

Pharmacokinetic data

Protein binding >98%
Excreted unchanged in urine 50 (as metabolites)
Biological half-life 8-10 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  T
Risk Statements  25
Safety Statements  36/37-45
RIDADR  UN 2811
WGK Germany  3
HS Code  2933.39.4100
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Toxicity LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi)
NFPA 704
0
2 0

Lercanidipine hydrochloride price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L6668 Lercanidipine hydrochloride ≥98% (HPLC) 132866-11-6 10mg $225 2026-04-30 Buy
Sigma-Aldrich L6668 Lercanidipine hydrochloride ≥98% (HPLC) 132866-11-6 50mg $638 2026-04-30 Buy
TCI Chemical L0282 Lercanidipine Hydrochloride >98.0%(HPLC)(T) 132866-11-6 200mg $18 2026-04-30 Buy
TCI Chemical L0282 Lercanidipine Hydrochloride >98.0%(HPLC)(T) 132866-11-6 1g $37 2026-04-30 Buy
Cayman Chemical 29104 Lercanidipine (hydrochloride) ≥98% 132866-11-6 50mg $42 2026-04-30 Buy
Product number Packaging Price Buy
L6668 10mg $225 Buy
L6668 50mg $638 Buy
L0282 200mg $18 Buy
L0282 1g $37 Buy
29104 50mg $42 Buy

Lercanidipine hydrochloride Chemical Properties, Uses, Production

Chemical Properties

Pale-Yellow Powder

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

long-acting dihydropyridine calcium channel blocker, antihypertensive

Definition

ChEBI: Lercanidipine hydrochloride is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Biological Activity

L-type Ca 2+ channel blocker that displays higher vascular selectivity than Felodipine (4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester ). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive.

Biochem/physiol Actions

Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine.

Synthesis

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, ethanedioate (1:1)

957215-03-1

Lercanidipine hydrochloride

132866-11-6

The general procedure for the synthesis of 3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride from the compound (CAS:957215-03-1) is as follows: 10 mmol of oxalate salt (Example 4) was dissolved in 100 mL of dichloromethane and 20 mL of aqueous solution containing 20 mmol of potassium carbonate was added. The organic phase was separated and the aqueous phase was extracted with 2 x 10 mL of dichloromethane. The organic phase was combined and treated with 20 mL of 1N hydrochloric acid solution. The organic phase was separated and concentrated. The residue was dissolved in 2,000 mL of water and 2 mL of 1N hydrochloric acid and 5 mL of saturated aqueous sodium chloride were added to form I hydrochloride hemihydrate and the product was collected by filtration. Yield: 6.2 g (95%); Purity: 99.8% (HPLC); Melting point: 118-122 ° C. HPLC conditions: RP 16 column, 125×3 mm ID, 5 μm, Detection wavelength: 233 nm; Eluent composition: 0.01 mol Na2HPO4/MeOH/acetonitrile=25/65/10; Retention time: about 15 min.

Description

BCL10 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-233) and having a molecular mass of 28.8kDa (molecular weight on SDS-PAGE will appear higher).
BCL10 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Ecoli

Background

BCL10 holds a caspase recruitment domain (CARD), and is known as an inducer of apoptosis and as NF-kappaB activator. BCL10 cooperates with other CARD domain containing proteins such as CARD9, 10, 11 and 14, which operates as upstream regulators in NF-kappaB signaling. BCL10 is known to create a complex with MALT1, a protein encoded by another gene and is translocated in MALT lymphoma. MALT1 and BCL10 protein synergize the activation of NF-kappaB, and the deregulation of either of them facilitates the same pathogenetic process which leads to the malignancy.

References

[1] Patent: EP1860102, 2007, A1. Location in patent: Page/Page column 1; 8; 15

Lercanidipine hydrochloride synthesis

100427-26-7
132866-11-6
Synthesis of Lercanidipine hydrochloride from Lercanidipine

Lercanidipine hydrochloride Preparation Products And Raw materials

Raw materials

Lercanidipine Impurity 26 2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester Hydrochloride Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester N-Methyl-3,3-diphenylpropylamine Lercanidipine
2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol methyl 3-aminocrotonate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, ethanedioate (1:1) Methyl 3-aminocrotonate 3-Nitrobenzaldehyde

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Preparation Products

Lercanidipine hydrochloride Suppliers

Global Suppliers ( 414)
Supplier Tel Email Country ProdList Advantage
Nanjing Machido Pharmaceutical Technology Co., Ltd. 19556085883 sales@machidopharma.com China 393 58
Hefei Qiming Pharmaceutical Technology Co., Ltd 15105695099 123642210@qq.com China 929 58
Suzhou Yuanhuan Pharmaceutical Technology Co., Ltd. 0512-18136053398 18136053398 2982784935@qq.com China 80 58
Suzhou lipin Chemical Co., Ltd 0512-67509664 19888480046 3516936381@qq.com China 111 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Nanjing Machido Pharmaceutical Technology Co., Ltd. 58
Hefei Qiming Pharmaceutical Technology Co., Ltd 58
Suzhou Yuanhuan Pharmaceutical Technology Co., Ltd. 58
Suzhou lipin Chemical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
Chembest Research Laboratories Limited 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59

View Latest Price from Lercanidipine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lercanidipine hydrochloride pictures 2026-09-17 Lercanidipine hydrochloride
132866-11-6
 0.99 RongNa Biotechnology Co.,Ltd
Lercanidipine hydrochloride pictures 2026-09-17 Lercanidipine hydrochloride
132866-11-6
 1KG 99% 1000KG Hangzhou Hyper Chemicals Limited
Lercanidipine hydrochloride pictures 2026-07-27 Lercanidipine hydrochloride
132866-11-6
 $29.00-176.00 99.91% 10g TargetMol Chemicals Inc.

Lercanidipine hydrochloride Spectrum

Lercanidipine hydrochloride(132866-11-6)1HNMR

132866-11-6 (Lercanidipine hydrochloride) Related Search:

Dimethyl carbonate Lercanidipine Quinolinic acid Dimethyl sulfate Dimethyl phthalate
Dacthal 2,6-Lutidine Dimethyl fumarate Dimethyl disulfide N,N-Dimethylallylamine
Topotecan hydrochloride 2,5-Dimethylpyridine Chromium picolinate Dimethyl sulfoxide Ethane
2,5-Pyridinedicarboxylic acid Dimethylaminopyridine, polymer-bound 1-AdaMantanethylaMine

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1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride LERCANIDIPINE HYDROCHLORIDE 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride 3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl] 5-Methyl ester,hydrochloride (1:1) Lercanidipine Impurity 1 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester 3,5-pyridinedicarboxylic acid hydrochloride B-cell CLL/lymphoma 10 B-cell lymphoma/leukemia 10 BCL10 CARD-containing molecule enhancing NF-κ-B BCL-10 human c-E10 CIPER CLAP mE10 Lercanidipine hydrochloride hemihydrate, ≥98% (HPLC) -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride -2-methylpropan-2-yl) 3-(1-((3,3-Diphenylpropyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl) LERCANIDIPINEHYDROCHLORIDE(FORR&DONLY) Lercanidipine hemihydrate hydrochloride 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-[2-[3,3-diphenylpropyl(methyl)amino]-1,1-dimethyl-ethyl] ester O5-methyl ester hydrochloride 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride O3-[1-[3,3-diphenylpropyl(methyl)amino]-2-methyl-propan-2-yl] O5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride Lercaridipine Cardiovasc CarMen Corifeo Lercadip Lercan Lercapin Lercaton LerkaMen LerzaM R 75 Renovia Vasodip Zandip Zanicor 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5- LercanidipineHydrochloride> ercanidipine hydrochL Lercanidipine hydrochloride USP/EP/BP Lercanidipine HCL WS Lercanidipine HCl (REC 15-237, Lercadip, Lerdip, Zanidip) Lercanidipine HydrochlorideQ: What is Lercanidipine Hydrochloride Q: What is the CAS Number of Lercanidipine Hydrochloride Q: What is the storage condition of Lercanidipine Hydrochloride Q: What are the applications of Lercanidipine Hydrochloride TIANFU CHEM Lercanidipine hydrochloride NSC 405365 NSC405365 NSC-405365 Lercanidipine HCL Powder USP Standard Lercanidpine Hydrochoride Lecardipine hydrochloride Corifeo|||Carmen|||Cardiovasc Lercanidipine hydrochloride, 10 mM in DMSO