Disuccinimidyl glutarate
- CAS No.
- 79642-50-5
- Chemical Name:
- Disuccinimidyl glutarate
- Synonyms
- DSG;Bis(2,5-dioxopyrrolidin-1-yl) glutarate;DG1;CDHF4;EPKHE;PPKS1;SPPK1;EPKHIA;DSG Crosslinker;DISUCCINIMIDYL GLUTARATE
- CBNumber:
- CB0373852
- Molecular Formula:
- C13H14N2O8
- Molecular Weight:
- 326.26
- MDL Number:
- MFCD00153597
- MOL File:
- 79642-50-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 168-172 °C |
|---|---|
| Boiling point | 485.1±55.0 °C(Predicted) |
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in dimethylsulfoxide and dimethylformamide. |
| form | Solid |
| color | White to Off-White |
| Appearance | White solid |
| Water Solubility | Partially soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 8575145 |
| Stability | Hygroscopic, Moisture Sensitive, Unstable in Aqueous Solution |
| InChI | InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2 |
| InChIKey | LNQHREYHFRFJAU-UHFFFAOYSA-N |
| SMILES | C(ON1C(=O)CCC1=O)(=O)CCCC(ON1C(=O)CCC1=O)=O |
| CAS DataBase Reference | 79642-50-5 |
| UNSPSC Code | 12161502 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29280000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Disuccinimidyl glutarate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 80424 | Di(N-succinimidyl) glutarate ≥97.0% (CHN) | 79642-50-5 | 5mg | $48.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 80424 | Di(N-succinimidyl) glutarate ≥97.0% (CHN) | 79642-50-5 | 50mg | $360 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB2501785 | Anti-DSG1 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 79642-50-5 | 100μG | $545 | 2023-01-07 | Buy |
| TCI Chemical | D5445 | Disuccinimidyl Glutarate | 79642-50-5 | 250MG | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 20646 | Disuccinimidyl Glutarate ≥95% | 79642-50-5 | 5mg | $36 | 2026-04-30 | Buy |
Disuccinimidyl glutarate Chemical Properties, Uses, Production
Description
Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.
Chemical Properties
DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step crosslinking strategy greatly improves the ChIP assay. Disuccinimidyl crosslinkers include disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), and bis-N-succinimidyl-(pentaethylene glycol) ester (BS(PEG)5)[1]. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSS (crosslinker arm length = 11.4Å), DSG (crosslinker arm length = 7.5Å), and disuccinimidyl tartrate (DST, crosslinker arm length = 5.8Å) are homobifunctional crosslinking reagents that react specifically with primary amines[2]. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then added to an aqueous crosslinking reaction. The directly water-soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.
Characteristics
Features of disuccinimidyl glutarate:
Reactive groups: NHS ester (both ends)
Reactive towards: amino groups (primary amines)
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Membrane-permeable, allowing for intracellular crosslinking
Can increase crosslinking efficiency compared to DSS in some applications
Uses
Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.
General Description
DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step cross-linking strategy greatly improves the ChIP assay.
DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. The directly water soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.
reaction suitability
reagent type: cross-linking reagent
References
[1] JeeYoung Kim, Min Park, Gun Yong Sung. “Efficient Portable Urea Biosensor Based on Urease Immobilized Membrane for Monitoring of Physiological Fluids.” Biomedicines (2020).
[2] Petr Novak. “A top-down approach to protein structure studies using chemical cross-linking and Fourier transform mass spectrometry.” European Journal of Mass Spectrometry 9 6 (2003): 623–31.
Disuccinimidyl glutarate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai ShuaiDian MEDICAL TECHNOLOGY CO.,LTD. | 15821556986 | shshuaidian@126.com | China | 142 | 58 |
| Suzhouhongxiong | 18051745768 | Suzhouhongxiong@163.com | China | 60 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 17634413542 | 1959525201@qq.com | China | 9011 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
View Latest Price from Disuccinimidyl glutarate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-10 | Disuccinimidyl glutarate
79642-50-5
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-06-02 | DSG Crosslinker
79642-50-5
|
$39.00-89.00 | 98.74% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-01-15 | bis(2,5-dioxopyrrolidin-1-yl)pentanedioate
79642-50-5
|
1KG | 99.2% | 100 tons | Honest Joy Holdings Limited |
-
- Disuccinimidyl glutarate
79642-50-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- DSG Crosslinker
79642-50-5
- $39.00-89.00
- 98.74%
- TargetMol Chemicals Inc.
-
- bis(2,5-dioxopyrrolidin-1-yl)pentanedioate
79642-50-5
- $0.00
- 99.2%
- Honest Joy Holdings Limited
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