ASP7663
- CAS No.
- 1190217-35-6
- Chemical Name:
- ASP7663
- Synonyms
- ASP7663;ASP7663 >=98% (HPLC);ASP7663, 10 mM in DMSO;ASP 7663;ASP-7663;ASP7663;(E)-2-(7-Fluoro-1-isobutyl-2-oxoindolin-3-ylidene)acetic acid;(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid;Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-;pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663
- CBNumber:
- CB03959569
- Molecular Formula:
- C14H14FNO3
- Molecular Weight:
- 263.26
- MDL Number:
- MOL File:
- 1190217-35-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ASP7663 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5178 | ASP7663 ≥98%(HPLC) | 1190217-35-6 | 10 | $212 | 2021-12-16 | Buy |
| Tocris | 5178 | ASP7663 ≥98%(HPLC) | 1190217-35-6 | 50 | $887 | 2021-12-16 | Buy |
| TRC | A780113 | ASP7663 | 1190217-35-6 | 1mg | $110 | 2021-12-16 | Buy |
| Usbiological | 254683 | ASP 7663 | 1190217-35-6 | 10mg | $460 | 2021-12-16 | Buy |
| ChemScene | CS-0022157 | ASP7663 99.16% | 1190217-35-6 | 50mg | $480 | 2021-12-16 | Buy |
ASP7663 Chemical Properties,Uses,Production
Uses
ASP 7663 is a novel and selective transient receptor potential ankyrin 1 (TRPA1) agonist, which can be an effective anti-constipation drug with abdominal analgesic effect
Biological Activity
ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC50 values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.
in vivo
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice[1].
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide[1].
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat[1].
| Animal Model: | CRD model (colorectal distension in rat)[1]. |
| Dosage: | 1 and 3 mg/kg. |
| Administration: | Orally. |
| Result: | Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment. |
storage
Store at +4°C
ASP7663 Preparation Products And Raw materials
Raw materials
Preparation Products
ASP7663 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
