BuforMin Hydrochloride
- CAS No.
- 1190-53-0
- Chemical Name:
- BuforMin Hydrochloride
- Synonyms
- BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
- CBNumber:
- CB0407151
- Molecular Formula:
- C6H16ClN5
- Molecular Weight:
- 193.68
- MDL Number:
- MFCD00045591
- MOL File:
- 1190-53-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 177-179C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | H2O: 25mg/mL, clear |
| Stability | Hygroscopic |
| InChI | 1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H |
| InChIKey | KKLWSPPIRBIEOV-UHFFFAOYSA-N |
| SMILES | [Cl-].N\C(=N/CCCC)\N=C(N)N.[H+] |
| CAS DataBase Reference | 1190-53-0 |
| FDA UNII | D947SXO87P |
| NCI Drug Dictionary | buformin hydrochloride |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338+P310-P332+P313-P403+P233-P405-P501 | |||||||||
| target organs | Respiratory system | |||||||||
| Risk Statements | 22-43-36 | |||||||||
| Safety Statements | 36/39-46 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29212900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 i.p. in mice: 380 mg/kg (Rikimaru) | |||||||||
| NFPA 704 |
|
BuforMin Hydrochloride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6007 | Buformin Hydrochloride | 1190-53-0 | 50MG | $46 | 2026-04-30 | Buy |
| TCI Chemical | B6007 | Buformin Hydrochloride | 1190-53-0 | 250MG | $159 | 2026-04-30 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 100mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 250mg | $207 | 2026-04-30 | Buy |
| Cayman Chemical | 18507 | Buformin (hydrochloride) ≥95% | 1190-53-0 | 500mg | $392 | 2026-04-30 | Buy |
BuforMin Hydrochloride Chemical Properties, Uses, Production
Description
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Chemical Properties
White Solid
Originator
Silubin,Protochemie,Switz.
Uses
BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Uses
Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
Manufacturing Process
105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were ground intimately and mixed. The mixture was heated by means of an oil bath, gradually with stirring, and after thirty minutes when the internal temperature had reached 150°C, an exothermic reaction ensued with internal pressure rising to 178°C. The reaction mixture was removed from the oil bath until the internal temperature had fallen to 150°C and then heating was resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3 liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated.
Therapeutic Function
Antidiabetic
References
[1] RUSSELL A. MILLER. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP[J]. Nature, 2013, 494 7436: 256-260. DOI: 10.1038/nature11808
[2] AKIKO YANO. Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.[J]. Biological & pharmaceutical bulletin, 2006, 29 5: 1006-1009. DOI: 10.1248/bpb.29.1006
[3] HANNAH R BRIDGES. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.[J]. Biochemical Journal, 2014, 462 3: 475-487. DOI: 10.1042/bj20140620
[4] SAKAE SAITO. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.[J]. Cancer research, 2009: 4225-4234. DOI: 10.1158/0008-5472.can-08-2689
BuforMin Hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from BuforMin Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Buformin hydrochloride
1190-53-0
|
$30.00-64.00 | 97.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-03-16 | BuforMin Hydrochloride
1190-53-0
|
10g | 98%Min | 1000kg | LY Global chemicals co.,ltd . | ||
 |
2020-02-11 | Buformin Hydrochloride
1190-53-0
|
$9.80 | 1g | ＞98% | 20 tons | Career Henan Chemical Co |
-
- Buformin hydrochloride
1190-53-0
- $30.00-64.00
- 97.83%
- TargetMol Chemicals Inc.
-
- BuforMin Hydrochloride
1190-53-0
- 98%Min
- LY Global chemicals co.,ltd .
-
- Buformin Hydrochloride
1190-53-0
- $9.80
- ＞98%
- Career Henan Chemical Co
