Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-Chloro-7-fluoroquinoline

4-Chloro-7-fluoroquinoline

4-Chloro-7-fluoroquinoline Structure
4-Chloro-7-fluoroquinoline structure
CAS No.
391-82-2
Chemical Name:
4-Chloro-7-fluoroquinoline
Synonyms
4-Chloro-7-fluoroquinoline;Quinoline, 4-chloro-7-fluoro-
CBNumber:
CB0422066
Molecular Formula:
C9H5ClFN
Molecular Weight:
181.59
MDL Number:
MFCD00153094
MOL File:
391-82-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:20
Request For Quotation

4-Chloro-7-fluoroquinoline Properties

Melting point 73.5-74 °C
Boiling point 259.9±20.0 °C(Predicted)
Density 1.366±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 2.38±0.27(Predicted)
color White to Pale Yellow
InChI 1S/C9H5ClFN/c10-8-3-4-12-9-5-6(11)1-2-7(8)9/h1-5H
InChIKey TTXZTTXOYYOVEV-UHFFFAOYSA-N
SMILES FC1=CC=C2C(Cl)=CC=NC2=C1
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  WGK 3
HS Code  2933499090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral

4-Chloro-7-fluoroquinoline price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BBO000702 4-Chloro-7-fluoroquinoline 1 g $379 2026-04-30 Buy
Apolloscientific PC404563 4-Chloro-7-fluoroquinoline 95% 391-82-2 1g $59 2026-06-04 Buy
Activate Scientific AS124779 4-Chloro-7-fluoro-quinoline 96% 391-82-2 1g $89 2026-06-04 Buy
Activate Scientific AS124779 4-Chloro-7-fluoro-quinoline 96% 391-82-2 5g $273 2026-06-04 Buy
Matrix Scientific 292031 4-Chloro-7-fluoroquinoline 391-82-2 1.00g $82 2026-05-19 Buy
Product number Packaging Price Buy
BBO000702 1 g $379 Buy
PC404563 1g $59 Buy
AS124779 1g $89 Buy
AS124779 5g $273 Buy
292031 1.00g $82 Buy

4-Chloro-7-fluoroquinoline Chemical Properties, Uses, Production

Synthesis

7-FLUORO-4-HYDROXYQUINOLINE

391-83-3

4-CHLORO-7-FLUOROQUINOLINE

391-82-2

General procedure for the synthesis of 4-chloro-7-fluoroquinoline from 7-fluoro-4-hydroxyquinoline: 7-fluoro-4-hydroxyquinoline (1.1 g, 6.7 mmol) was added to an oven-dried round-bottomed flask, followed by the addition of pure phosphorus oxychloride (15 mL). The reaction mixture was heated and stirred at 70 °C for 3 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure, and then the concentrate was carefully poured into pre-cooled ice water (30 mL) and neutralized to pH neutral with aqueous sodium bicarbonate. The aqueous phase was extracted several times with dichloromethane (5 × 20 mL), and the combined organic phases were washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a hexane solution of 10%-40% ethyl acetate to afford the target product 4-chloro-7-fluoroquinoline (1.2 g, 98% yield) as a white solid. the Rf value was 0.7 (hexane solution of 40% ethyl acetate, UV activity). Mass Spectrometry (ESI) m/z (M+H) calculated value: 182.59, measured value: 182.6. 1H-NMR (500 MHz, CDCl3) δ 8.71 (d, J = 3.6 Hz, 1H), 8.32-8.21 (m, 1H), 7.69-7.64 (m, 1H), 7.59 (d, J = 3.6 Hz, 1H). 7.52-7.41 (m, 1H).13C-NMR (100 MHz, CDCl3) δ 164.7, 162.2, 151.03, 150.24, 150.11, 142.66, 126.58, 126.49, 123.54, 120.61, 118.19, 177.94, 113.56, 113.35.

References

[1] Patent: WO2017/79260, 2017, A1. Location in patent: Page/Page column 85
[2] Journal of the American Chemical Society, 1958, vol. 80, p. 1421,1422
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 371,373
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[5] Molecules, 2016, vol. 21, # 1,

4-Chloro-7-fluoroquinoline Preparation Products And Raw materials

Raw materials

7-Fluoro-4-hydroxyquinoline

Preparation Products

4-Chloro-7-fluoroquinoline Suppliers

Global Suppliers ( 67)
Supplier Tel Email Country ProdList Advantage
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai ChriChem Co., Ltd. 021-54880687 China 510 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 02161555100 China 820 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Shanghai Kahn Pharmaceutical Co., Ltd. 021-34979681; 17701870669 41513101@qq.com China 1789 55
Shanghai Carlow Chemicals Co., Ltd. 21-33526724 18930996265 info@carlowchem.com China 1820 50
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Supplier Advantage
Beijing Ouhe Technology Co., Ltd 60
SynAsst Chemical. 55
Shanghai ChriChem Co., Ltd. 55
Bide Pharmatech Ltd. 60
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
JW & Y Pharmlab Co., Ltd. 58
Shanghai Kahn Pharmaceutical Co., Ltd. 55
Shanghai Carlow Chemicals Co., Ltd. 50
SuZhou ShiYa Biopharmaceuticals, Inc. 58

View Latest Price from 4-Chloro-7-fluoroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-CHLORO-7-FLUOROQUINOLINE pictures 2019-12-27 4-CHLORO-7-FLUOROQUINOLINE
391-82-2
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

4-Chloro-7-fluoroquinoline Spectrum

4-CHLORO-7-FLUOROQUINOLINE(391-82-2)1HNMR4-CHLORO-7-FLUOROQUINOLINE(391-82-2)1HNMR4-CHLORO-7-FLUOROQUINOLINE(391-82-2)19FNMR

391-82-2 (4-Chloro-7-fluoroquinoline) Related Search:

meperfluthrin 4-chloro-7-fluoro-2-pyridin-2-ylquinoline 4-chloro-2-(2-chlorophenyl)-7-fluoroquinoline ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylate 4-chloro-7-fluoro-2-phenylquinoline
BUTTPARK 89\09-02 BUTTPARK 147\04-17 Ethyl 4-chloro-5,7-difluoroquinoxaline-3-carboxylate 4-Chloro-7-fluoro-6-methyl-2-(trifluoromethyl)quinoline 4-Chloro-6,7-difluoroquinoline
4-Chloro-7-fluoroquinoline 4-Chloro-7-fluoro-2-methylquinoline 4-Chloro-7-fluoro-6-methoxy-quinoline-3-carbonitrile 4-Chloro-7-fluoro-quinoline-3-carbonitrile 4-Chloro-6,7-difluoro-quinoline-3-carbonitrile

1of3

Quinoline, 4-chloro-7-fluoro- 4-Chloro-7-fluoroquinoline 391-82-2