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Cianidanol

Cianidanol Structure
Cianidanol structure
CAS No.
154-23-4
Chemical Name:
Cianidanol
Synonyms
CATECHIN;(+)-catechin;D-CATECHIN;Catechine;catergen;Cianidano;catechinicacid;(2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol;(2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol;kb-53
CBNumber:
CB0428149
Molecular Formula:
C15H14O6
Molecular Weight:
290.27
MDL Number:
MFCD00075649
MOL File:
154-23-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Cianidanol Properties

Melting point 175-177 °C (anhydrous)(lit.)
alpha D18 +16 to +18.4°
Boiling point 352.36°C (rough estimate)
Density 1.2451 (rough estimate)
refractive index 1.4359 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated, Heated)
form Solid
pka 9.54±0.10(Predicted)
color Light Orange to Light Brown
Merck 14,1902
Major Application food and beverages
InChI 1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1
InChIKey PFTAWBLQPZVEMU-DZGCQCFKSA-N
SMILES O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3
LogP 0.510
CAS DataBase Reference 154-23-4
NCI Dictionary of Cancer Terms catechin
FDA UNII 8R1V1STN48
EPA Substance Registry System 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3450000
F  8-10-23
HS Code  29329990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Toxicity LD50 oral in rat: > 10gm/kg

Cianidanol price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 43412 (+)-Catechin analytical standard 154-23-4 10mg $458 2026-04-30 Buy
Sigma-Aldrich 1096790 (+)-Catechin United States Pharmacopeia (USP) Reference Standard 154-23-4 25mg $396 2026-04-30 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 1g $61 2025-07-31 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 10g $301 2025-07-31 Buy
Usbiological 300053 Catechin ≥98% 154-23-4 20mg $263 2026-06-03 Buy
Product number Packaging Price Buy
43412 10mg $458 Buy
1096790 25mg $396 Buy
C0705 1g $61 Buy
C0705 10g $301 Buy
300053 20mg $263 Buy

Cianidanol Chemical Properties, Uses, Production

Chemical Properties

Tan Solid

Uses

procollagen production inhibitoe, hepatoprotectant

Uses

Labelled (+)-Catechin (C217500). (+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.
These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.

Definition

ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.

brand name

Ausoliver;Cirramina;Transepar.

World Health Organization (WHO)

Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.

General Description

(+)-Catechin is an important beneficial compound, belonging to the flavonoid class, which is present abundantly in red wine.

Cianidanol synthesis

20728-73-8
154-23-4
Synthesis of Cianidanol from (2R-trans)-2-[3,4-bis(phenylmethoxy)phenyl]-3,4-dihydro-5,7-bis(phenylmethoxy)-2H-1-benzopyran-3-ol

Cianidanol Preparation Products And Raw materials

Raw materials

Preparation Products

CACAO PIGMENT Procyanidin B1

Cianidanol Suppliers

Global Suppliers ( 458)
Supplier Tel Email Country ProdList Advantage
Raw material medicin reagent co.,Ltd sales@njromanme.com China 4511 58
Beijing OKA biological technology co., LTD 010-62971590 18548936886 3462612863@qq.com China 10061 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Supplier Advantage
Raw material medicin reagent co.,Ltd 58
Beijing OKA biological technology co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Shanghai Longsheng chemical Co.,Ltd. 59

View Latest Price from Cianidanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cianidanol; Green tea extract pictures 2026-09-11 Cianidanol; Green tea extract
154-23-4
 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Catechin pictures 2026-07-27 Catechin
154-23-4
 $30.00-50.00 99.73% 10g TargetMol Chemicals Inc.
Catechin pictures 2026-07-27 Catechin
154-23-4
 $30.00-50.00 99.73% 10g TargetMol Chemicals Inc.
  • Catechin pictures
  • Catechin
    154-23-4
  • $30.00-50.00
  • 99.73%
  • TargetMol Chemicals Inc.
  • Catechin pictures
  • Catechin
    154-23-4
  • $30.00-50.00
  • 99.73%
  • TargetMol Chemicals Inc.

Cianidanol Spectrum

Cianidanol(154-23-4)MSCianidanol(154-23-4)1HNMRCianidanol(154-23-4)IR1Cianidanol(154-23-4)IR2

154-23-4 (Cianidanol) Related Search:

2-Phenylphenol Tetrahydro-4H-pyran-4-one Hydroxy silicone oil Catechol Tetrahydropyran
Triphenylphosphine Procyanidin Tea polyphenol Silybin (-)-CATECHIN GALLATE
Silychristin Dihydromyricetin L-Epicatechin (-)-CATECHIN HYDRATE Procyanidin B1
(±)-Catechin (-)-Epigallocatechin Phenylacetone

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CATECHIN, (+)- (+)-3,3'4',5,7-FLAVANEPENTOL 3,3',4',5,7-PENTAHYDROXYFLAVANE [2R,3S]-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-1[2H]-BENZOPYRAN-3,4,7-TRIOL 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h-1-benzopyran-7-triol 5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-trans)-2H-1-Benzopyran-3 catechin(flavan) catechol(flavan) catechuicacid cianidanol d-catechol kb-53 2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol (2R,3S) CATECHIN 85% (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (+)-CATECHIN WITH HPLC 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- Catechin，Cianidanol，Cyanidol (+)-Cyanidan-3-ol 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)- Cyanidanol (2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol CATECHIN, (+)-(AHP)(CALL) (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol Cianidano (+)-Catechin 154-23-4 (+)-Catechin, froM green tea (+)-Catechin (25 mg) Catechin(C) (2R,3S)- (+)-Catechin-d3 Biocatechin Cianidanol, Dexcyanidanol Drenoliver Tanningenic acid Cianidanol,(+)-Catechin hydrate Cianidanol(EGCG) (+)-Cyanidol-3 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol (+)-Catechin, 99%, from green tea (+)-Catechin Standard (+)-Catechin Hydrate> Cianidanol Solution, 100μg/mL Cianidanol USP/EP/BP (+)-Catechin (1096790) (+)-Catechin C (+)-Catechin-RM Cianidanol (+)-Catechin 1000 μg/mL in Acetonitrile Catechin (Standard) (+)-catechin (2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol CATECHIN catechinicacid catergen Catechine D-CATECHIN (+)-Catechin ≥96% (+)-Catechin ≥98%