(RS)-(Tetrazol-5-yl)glycine
- CAS No.
- 138199-51-6
- Chemical Name:
- (RS)-(Tetrazol-5-yl)glycine
- Synonyms
- C13738;LY 285265;Tet-glycine;Tetrazolyl Glycine;(RS)-(Tetrazol-5-yl);5-Tetrazolyl-glycine;(tetrazol-5-yl)glycine;L-(tetrazol-5-yl)glycine;(RS)-(Tetrazol-5-yl)glycine;aMino(2H-tetrazol-5-yl)acetic acid
- CBNumber:
- CB0429449
- Molecular Formula:
- C3H5N5O2
- Molecular Weight:
- 143.1
- MDL Number:
- MFCD00233633
- MOL File:
- 138199-51-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 447.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.804±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: 0.25mg/mL; PBS (pH 7.2): 0.2mg/mL |
| form | Powder |
| pka | 1.04±0.10(Predicted) |
| Water Solubility | Soluble to 50 mM in water |
| FDA UNII | U9YSJ8VXX9 |
(RS)-(Tetrazol-5-yl)glycine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28408 | Tetrazolyl Glycine ≥95% | 138199-51-6 | 10mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 28408 | Tetrazolyl Glycine ≥95% | 138199-51-6 | 25mg | $316 | 2026-04-30 | Buy |
| Cayman Chemical | 28408 | Tetrazolyl Glycine ≥95% | 138199-51-6 | 50mg | $598 | 2026-04-30 | Buy |
| Cayman Chemical | 28408 | Tetrazolyl Glycine | 138199-51-6 | 100mg | $693 | 2021-12-16 | Buy |
| Usbiological | 256515 | (RS)-(Tetrazol-5-yl)glycine Asreported | 138199-51-6 | 10mg | $480 | 2026-06-03 | Buy |
(RS)-(Tetrazol-5-yl)glycine Chemical Properties, Uses, Production
Description
Tetrazolyl glycine is an NMDA receptor agonist. It binds to rat brain membranes with IC50 values of 98 and 36 nM for [3H]CGS19755 and [3H]glutamate, respectively, in radioligand binding assays. It induces depolarization in rat cortical slices, an effect that is blocked by the NMDA receptor antagonist LY233053. It induces degeneration of GABAergic and cholinergic neurons in the striatum of adult rats and the formation of excitotoxic lesions and seizures in neonatal rats (ED50 = 0.071 mg/kg). Intrastriatal injection of tetrazolyl glycine (5 μM) increases COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity-induced neuronal injury.
Uses
(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating ~ 20X more activity than NMDA.
Definition
ChEBI: Tet-glycine is a non-proteinogenic alpha-amino acid.
in vivo
(RS)-(Tetrazol-5-yl)glycine can be used in animal modeling to create epilepsy models and is able to penetrate the blood-brain barrier[4].
Administration: 0.2 and 0.4 μL of a 0.7 mM (RS)-(Tetrazol-5-yl)glycine solution ICV
(2) Among the 11 rats injected with 0.28 nmol (RS)-(Tetrazol-5-yl) glycine, 5 died within a few hours after injection, making it impossible to perfuse and determine the degree of hippocampal lesions.
(3) There was no loss of hippocampal neurons in two of the four rats injected with the lower dose of (RS) - (Tetrazol-5-yl) glycine, whereas the other two showed loss of pyramidal neurons in the medial portion of CA1, and granule neurons in the dentate gyrus.
Behavioral observation: Continuous flicking of the tail, rowing movements, and convulsions.
| Animal Model: | C57BL/6 mice[3] |
| Dosage: | 1.25, 1.5 mg/kg |
| Administration: | IP |
| Result: | Induced seizure responses and Fos. |
IC 50
NMDA Receptor
storage
Store at RT
References
[1] DARRYLE D. SCHOEPP . D,L-(Tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist[J]. European journal of pharmacology, 1991, 203 2: Pages 237-243. DOI: 10.1016/0014-2999(91)90719-7
[2] DARRYLE D. SCHOEPP . The NMDA receptor agonist DL-(tetrazol-5-yl) glycine is a highly potent excitotoxin[J]. European Journal of Pharmacology: Environmental Toxicology and Pharmacology, 1994, 270 1: Pages 67-72. DOI: 10.1016/0926-6917(94)90081-7
[3] YING AN. Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge[J]. Journal of Neuroscience Research, 2013, 92 4: 486-495. DOI: 10.1002/jnr.23317
(RS)-(Tetrazol-5-yl)glycine Preparation Products And Raw materials
Raw materials
Preparation Products
(RS)-(Tetrazol-5-yl)glycine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3057 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19904 | 58 |
View Latest Price from (RS)-(Tetrazol-5-yl)glycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | (RS)-(Tetrazol-5-yl)glycine
138199-51-6
|
$35.00-148.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- (RS)-(Tetrazol-5-yl)glycine
138199-51-6
- $35.00-148.00
- 99.89%
- TargetMol Chemicals Inc.
