3-Carbamyl-1-methylpyridinium chloride
- CAS No.
- 1005-24-9
- Chemical Name:
- 3-Carbamyl-1-methylpyridinium chloride
- Synonyms
- 1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;TRIA-662, 10 mM in DMSO;Nicotinamide Impurity F;nicotinamidemethochloride;nipecotamidemethochloride;1-Methylnicotine Chloride;Nicotinamide Impurity 127
- CBNumber:
- CB0431956
- Molecular Formula:
- C7H9ClN2O
- Molecular Weight:
- 172.61
- MDL Number:
- MFCD00060042
- MOL File:
- 1005-24-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207-209℃ (water acetone ) |
|---|---|
| storage temp. | room temp |
| solubility | H2O: soluble15mg/mL, clear |
| form | crystalline |
| color | white |
| Water Solubility | almost transparency |
| Merck | 14,9693 |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING SKIN PROTECTING |
| InChI | 1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H |
| InChIKey | BWVDQVQUNNBTLK-UHFFFAOYSA-N |
| SMILES | Cl.[n+]1(cc(ccc1)C(=N)[O-])C |
| CAS DataBase Reference | 1005-24-9(CAS DataBase Reference) |
| FDA UNII | L54XNJ1D5G |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU1925000 | |||||||||
| HS Code | 2933.39.9200 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Carbamyl-1-methylpyridinium chloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0704 | 1-Methylnicotinamide chloride ≥98% (HPLC) | 1005-24-9 | 10mg | $48.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2091 | Nicotinamide Impurity F Pharmaceutical Secondary Standard; Certified Reference Material | 1005-24-9 | 100 mg | $341 | 2026-04-30 | Buy |
| Sigma-Aldrich | M4627 | 1-Methylnicotinamide chloride analytical standard | 1005-24-9 | 1g | $193 | 2026-04-30 | Buy |
| TCI Chemical | M0375 | 3-Carbamyl-1-methylpyridinium Chloride >98.0%(HPLC)(T) | 1005-24-9 | 5g | $114 | 2026-04-30 | Buy |
| TCI Chemical | M0375 | 3-Carbamyl-1-methylpyridinium Chloride >98.0%(HPLC)(T) | 1005-24-9 | 25g | $305 | 2026-04-30 | Buy |
3-Carbamyl-1-methylpyridinium chloride Chemical Properties, Uses, Production
Description
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Uses
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Uses
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
General Description
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
Purification Methods
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
References
[1] THEODORE A. ALSTON Robert H A. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver[J]. Archives of biochemistry and biophysics, 1988, 260 2: Pages 601-608. DOI: 10.1016/0003-9861(88)90487-0
[2] TERESA B DOMAGALA. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.[J]. Hypertension, 2012, 59 4: 825-832. DOI: 10.1161/hypertensionaha.111.183210
[3] S CHLOPICKI. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway[J]. British Journal of Pharmacology, 2009, 152 2: 230-239. DOI: 10.1038/sj.bjp.0707383
3-Carbamyl-1-methylpyridinium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-Carbamyl-1-methylpyridinium chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Myland Nutraceuticals Inc. | 13771927830 | james@mylandpharm.com | China | 58 | 55 |
| Tianjin Rongshen Chemical Co., Ltd | 18317763565; 18317763565 | 18317763565@163.com | China | 9878 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from 3-Carbamyl-1-methylpyridinium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 1-Methylnicotinamide chloride
1005-24-9
|
1KG | 0.98 | 10000 KG | Nanjing pathgene biotech co .,ltd | ||
 |
2026-07-15 | TRIA-662
1005-24-9
|
$35.00-59.00 | 99.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 1-Methylnicotinamide chloride
1005-24-9
- 0.98
- Nanjing pathgene biotech co .,ltd
-
- TRIA-662
1005-24-9
- $35.00-59.00
- 99.77%
- TargetMol Chemicals Inc.
-
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
1005-24-9
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
