Amine:oxygen oxidoreductase [deaminating]
![Amine:oxygen oxidoreductase [deaminating] Structure](CAS/20180808/GIF/9001-66-5.gif)
- CAS No.
- 9001-66-5
- Chemical Name:
- Amine:oxygen oxidoreductase [deaminating]
- Synonyms
- TYRAMINE OXIDASE;Monoamine Oxidase;AOC3;SSAO;KAOD;Renalase;Tyraminase;VAP-1 human;MAO (enzyme);E.C. 1.4.3.4
- CBNumber:
- CB0445553
- Molecular Formula:
- C7H15N2O6P
- Molecular Weight:
- 254.177561
- MDL Number:
- MFCD00131620
- MOL File:
- 9001-66-5.mol
- MSDS File:
- SDS
| Density | 0.319[at 20℃] |
|---|---|
| vapor pressure | 0Pa at 25℃ |
| storage temp. | 2-8°C |
| form | lyophilized powder |
| color | White to off-white |
| biological source | human |
| Water Solubility | 102g/L at 30℃ |
| InChI | InChI=1/C7H15N2O6P/c8-5(7(11)12)2-1-3-9-6(10)4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H2,13,14,15)/t5-/s3 |
| InChIKey | FCIHAQFHXJOLIF-GQMHJJTINA-N |
| SMILES | C(O)(=O)[C@@H](N)CCCNC(CP(O)(O)=O)=O |&1:3,r| |
| LogP | -3 at 23℃ |
| CAS DataBase Reference | 9001-66-5 |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Hazard statements | H334 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501 |
| Safety Statements | 23-24/25 |
| WGK Germany | 3 |
| Storage Class | 10 - Combustible liquids |
| REACH Registrations | Active |
Amine:oxygen oxidoreductase [deaminating] price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3295 | VAP-1 human recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC) | 10μG | $367 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SRP6241 | VAP-1 human recombinant, expressed in CHO cells, ≥95% (SDS-PAGE) | 10μG | $363 | 2024-03-01 | Buy | |
| Usbiological | 555181 | AOC3 PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy | |
| Usbiological | 555181 | AOC3 PurifiedbyProteinGaffinitychromatography. | 100ug | $708 | 2026-06-03 | Buy | |
| Usbiological | 549654 | Renalase PurifiedbyProteinAandpeptideaffinitychromatography. | 200ul | $694 | 2026-06-03 | Buy |
Amine:oxygen oxidoreductase [deaminating] Chemical Properties, Uses, Production
Uses
Monoamine oxidase (EC 1.4.3.4) is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions[1][2].
Definition
An enzyme that is distributedwidely among animals. It inactivates a number ofbiogenic amines by catalyzing the oxidative deam-ination of these compounds.
Flammability and Explosibility
Not classified
Biological Activity
The protein VAP-1 (vascular adhesion protein-1) belongs to the group of semicarbazide sensitive amine oxidases (SSAO) th at catalyze the formation of reactive oxygen species. It is a unique adhesion molecule th at participates in inflammatory leukocyte recruitment in blood vessels. It functions in leukocyte extravasation to inflamed tissues. In the human eye, it has been associated with ocular inflammatory diseases, such as uveitis, age-related macular degeneration, and diabetic retinopathy. Its expression has been observed to be altered in several diseases, such as rheumatoid arthritis, diabetes, and atherosclerosis.
References
[1] Shih JC, et al. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci. 1999;22:197-217. DOI:10.1146/annurev.neuro.22.1.197
[2] Bortolato M, et al. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1527-33. DOI:10.1016/j.addr.2008.06.002
[3] Youdim MB, et al. The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci. 2006 Apr;7(4):295-309. DOI:10.1038/nrn1883
Amine:oxygen oxidoreductase [deaminating] Preparation Products And Raw materials
Raw materials
Preparation Products
Amine:oxygen oxidoreductase [deaminating] Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Baoman Biotechnology Co., Ltd. | 021-62130998 | baomanbio@163.com | China | 201 | 55 |
| Hubei wei shi reagent group ltd., company | 17771898297 13125137661 | 2853877621@qq.com | China | 7992 | 58 |
| Hubei wei shi reagent group ltd., company | 13125137732 18686406941 | 2853863890@qq.com | China | 2876 | 58 |
| Shanghai Baitai Xin Biotechnology Co., Ltd. | 13701899122 | 13701899122@163.com | China | 35 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Syncozymes (Shanghai) Co.,Ltd. | 021-68187180 13681683526 | lchen@syncozymes.com | China | 412 | 55 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
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