N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- CAS No.
- 314054-00-7
- Chemical Name:
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- Synonyms
- C-176;STING inhibitor 1;C-176, 10 mM in DMSO;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- CBNumber:
- CB04522191
- Molecular Formula:
- C11H7IN2O4
- Molecular Weight:
- 358.09
- MDL Number:
- MFCD00784208
- MOL File:
- 314054-00-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 361.2±37.0 °C(Predicted) |
|---|---|
| Density | 1.935±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO (up to 25 mg/ml) |
| pka | 11.14±0.70(Predicted) |
| form | solid |
| color | Brown or yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15) |
| InChIKey | JBIKQXOZLBLMKI-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2559 | C-176 ≥98% (HPLC) | 314054-00-7 | 10mg | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2559 | C-176 ≥98% (HPLC) | 314054-00-7 | 50mg | $435 | 2026-04-30 | Buy |
| Cayman Chemical | 25859 | C-176 ≥98% | 314054-00-7 | 10mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 25859 | C-176 ≥98% | 314054-00-7 | 25mg | $99 | 2026-04-30 | Buy |
| Cayman Chemical | 25859 | C-176 ≥98% | 314054-00-7 | 50mg | $187 | 2026-04-30 | Buy |
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties,Uses,Production
Description
C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activationviablockade of palmitoylation at Cys91. Treatment of Trex-/-mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
Uses
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].
in vivo
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 / mice[1].
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 / mice[1].
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
storage
Store at -20°C
References
[1] SIMONE M. HAAG. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018, 559 7713: 269-273. DOI:10.1038/s41586-018-0287-8
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai XinKai Chemical Technology Co., Ltd. | 021-58930698 15921516558 | zhangyichao84@126.com | China | 971 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
