DIKEGULAC DIHYDRAT
- CAS No.
- 18467-77-1
- Chemical Name:
- DIKEGULAC DIHYDRAT
- Synonyms
- diprogulic acid;dikegulac hydrate;DIKEGULAC DIHYDRAT;DIKEGULAC DIHYDRATE;DIACETONE-2-KETOGULONICACID;Oxogulonic acid diacetonide;Diacetone-2-oxo-L-gulonic acid;2,3,4,6-DIACETONE-2-KETOGULONIC ACID;Diprogulic acid (and its sodium salt);DIKEGULAC MONOHYDRATE PESTANAL 250 MG
- CBNumber:
- CB0464936
- Molecular Formula:
- C12H18O7
- Molecular Weight:
- 274.27
- MDL Number:
- MFCD00150519
- MOL File:
- 18467-77-1.mol
- MSDS File:
- SDS
| Melting point | 88-90 °C(lit.) |
|---|---|
| Boiling point | 375℃ |
| Density | 1.281 |
| Flash point | 140℃ |
| storage temp. | 2-8°C |
| pka | 1.77±0.60(Predicted) |
| Henry's Law Constant | 5.2×1010 mol/(m3Pa) at 25℃, HSDB (2015) |
| FDA UNII | 3981541LXD |
| EPA Substance Registry System | .alpha.-L-xylo-2-Hexulofuranosonic acid, 2,3:4,6-bis-O-(1-methylethylidene)- (18467-77-1) |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29329990 |
DIKEGULAC DIHYDRAT Chemical Properties, Uses, Production
Definition
ChEBI: Dikegulac is a member of dioxanes.
Production Methods
The commercial production of dikegulac typically begins with 2-keto-L-gulonic acid. This precursor is reacted with 2,2-dimethoxypropane under elevated temperatures in the presence of a strong acid catalyst, such as sulphuric acid, to form a protected intermediate via acetal formation. This intermediate contains the diacetonide structure characteristic of dikegulac. The reaction mixture is then treated with a base, often sodium hydroxide, to hydrolyse residual esters and neutralise the acid, yielding dikegulac sodium, the usual marketed formulation.
Mechanism of action
Decreases RNA synthesis, rapidly inhibits amino-acid uptake by cells
Purification Methods
Dissolve -DAG in Et2O, filter, dry (MgSO4) it, filter it again and evaporate to give a yellow oil. Addition of one drop of H2O induces crystallisation to the monohydrate, which also forms rhombic crystals on recrystallisation from 95% EtOH/H2O at room temperature. [Flatt et al. Synthesis 815 1979, Reichstein & Grussner Helv Chim Acta 17 311 1934, Takagi & Jeffrey Acta Crystallogr Sect B 34 2932 1978, cf Org Synth 55 80 1976, Beilstein 19/12 V 520.]
Pesticide Type
Plant Growth Regulator
DIKEGULAC DIHYDRAT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Shanghai TenSus Biotechnology Co., Ltd. | 021-50895067 18616507272;13681616114;15020344067 | tensus@163.com | China | 8029 | 58 |
| Shanghai Jiegu Biotechnology Co., Ltd. | 021-51698675 | sales@jiejiegroup.com | China | 8195 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6528 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29717 | 58 |
| Beijing Qinling Pharmaceutical Co., Ltd. | 010-61241352 18901327973 | 834537306@qq.com | China | 6234 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53636 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +86-15195660023 | 3899766280@qq.com | China | 26349 | 58 |
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