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2-Trifluoromethyl-4-chloropyridine

2-Trifluoromethyl-4-chloropyridine structure

CAS No.: 131748-14-6

Chemical Name:: 2-Trifluoromethyl-4-chloropyridine

Synonyms: 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE;4-Chloro-2-(TrifluoroMeth;-trifluoromethyl-4-chloropyridine;2-Trifluoromethyl-4-chloropyridine;-chloro-2-(trifluoromethyl)pyridine;Pyridine,4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)pyridine 99%;4-Chloro-2-(trifluoromethyl)pyridine,98%;2-Trifluoromethyl-4-Chloropyridine(WX636118);4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline

CBNumber:: CB0465418

Molecular Formula:: C6H3ClF3N

Molecular Weight:: 181.54

MDL Number:: MFCD07368047

MOL File:: 131748-14-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:48:20

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2-Trifluoromethyl-4-chloropyridine Properties

Boiling point	137.4±35.0 °C(Predicted)
Density	1.417
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.29±0.10(Predicted)
form	Liquid
color	Colorless
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C6H3ClF3N/c7-4-1-2-11-5(3-4)6(8,9)10/h1-3H
InChIKey	FZINIBTZNSPWQR-UHFFFAOYSA-N
SMILES	C1(C(F)(F)F)=NC=CC(Cl)=C1
CAS DataBase Reference	131748-14-6
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Hazard Codes

Xi,T

Risk Statements

25-36

Safety Statements

26-45

RIDADR

UN2811

WGK Germany

WGK 3

HazardClass

IRRITANT

HazardClass

6.1

HS Code

2933399990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2

NFPA 704

	1
3		0

2-Trifluoromethyl-4-chloropyridine price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC01677	4-Chloro-2-(trifluoromethyl)pyridine 99%	131748-14-6	1g	$21	2026-06-04	Buy
Apolloscientific	PC01677	4-Chloro-2-(trifluoromethyl)pyridine 99%	131748-14-6	5g	$24	2026-06-04	Buy
Apolloscientific	PC01677	4-Chloro-2-(trifluoromethyl)pyridine 99%	131748-14-6	25g	$79	2026-06-04	Buy
Activate Scientific	AS36251	4-Chloro-2-(trifluoromethyl)pyridine 98%	131748-14-6	1g	$31	2026-06-04	Buy
Activate Scientific	AS36251	4-Chloro-2-(trifluoromethyl)pyridine 98%	131748-14-6	5g	$66	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC01677	1g	$21	Buy
PC01677	5g	$24	Buy
PC01677	25g	$79	Buy
AS36251	1g	$31	Buy
AS36251	5g	$66	Buy

2-Trifluoromethyl-4-chloropyridine Chemical Properties, Uses, Production

Uses

Chloro(trifluoromethyl)pyridines derivatives are used as model substrates for regioexhaustive functionalization.

Synthesis

170886-13-2

131748-14-6

Example 1 Preparation of 4-chloro-2-trifluoromethylpyridine: In a 25 mL round-bottomed flask equipped with a reflux condenser, a magnetic stirrer, and vented with inert gas, 1.63 g (10.0 mmol) of 2-trifluoromethyl-4-hydroxypyridine was dissolved in a solvent mixture of 4.9 mL of cyclohexane and 0.077 mL of DMF. At room temperature, 2.19 mL (25.0 mmol) oxalyl chloride was slowly added. The reaction mixture was heated to reflux for 3 hours and subsequently cooled to room temperature. 18 mL of water was added slowly and dropwise (watch for gas release), then the reaction mixture was extracted with 18 mL of methyl tert-butyl ether (MTBE). The organic layer was separated, washed with 1 M sodium bicarbonate (NaHCO3) solution and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the solvent was evaporated under reduced pressure to give the crude product. The crude product was dissolved in 12 mL of hexane and stirred at room temperature for 5 min, filtered and evaporated under reduced pressure to give 0.9 g of 4-chloro-2-trifluoromethylpyridine as a yellow liquid. The product was analyzed by GC-EI-MS, showing molecular ion peaks at m/z 181 (M+) and m/z 183 (M+2).

References

[1] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00178
[2] Patent: WO2011/161612, 2011, A1. Location in patent: Page/Page column 13
[3] Patent: WO2014/76127, 2014, A1. Location in patent: Page/Page column 8
[4] Patent: WO2018/99812, 2018, A1. Location in patent: Page/Page column 70

2-Trifluoromethyl-4-chloropyridine Preparation Products And Raw materials

Raw materials

2-(Trifluoromethyl)pyridin-4-ol Cyclohexane N,N-Dimethylformamide Oxalyl chloride

Preparation Products

2-(Trifluoromethyl)isonicotinic acid

2-Trifluoromethyl-4-chloropyridine Suppliers

Global Suppliers ( 193)

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou HCK Biotech Co., Ltd.	18796480679 15295163861	3844328290@qq.com	China	602	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD	571-89189769 15168342188		China	228	62

Supplier	Advantage
Changzhou HCK Biotech Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Changzhou Huanling Chemical Co., Ltd.	68
Pure Chemistry Scientific Inc.	62
Tetranov Biopharm	64
Accela ChemBio Co.,Ltd.	64
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD	62

View Latest Price from 2-Trifluoromethyl-4-chloropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Trifluoromethyl-4-chloropyridine 131748-14-6	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2026-08-20	2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE 131748-14-6	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2019-07-12	2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE 131748-14-6	$1.00	1KG	99%	1ton	Career Henan Chemical Co

2-Trifluoromethyl-4-chloropyridine
131748-14-6
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
131748-14-6
$1.10
99.00%
Dideu Industries Group Limited

2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
131748-14-6
$1.00
99%
Career Henan Chemical Co

2-Trifluoromethyl-4-chloropyridine Spectrum

2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)¹HNMR 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)FT-IR

131748-14-6 (2-Trifluoromethyl-4-chloropyridine) Related Search:

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1of4

4-Chloro-2-(trifluoromethyl)pyridine 99% Pyridine,4-chloro-2-(trifluoromethyl)- 4-Chloro-2-(TrifluoroMeth 4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline 2-Trifluoromethyl-4-Chloropyridine(WX636118) 4-Chloro-2-(trifluoromethyl)pyridine,98% 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE ISO 9001：2015 REACH -chloro-2-(trifluoromethyl)pyridine -trifluoromethyl-4-chloropyridine 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE 2-Trifluoromethyl-4-chloropyridine 131748-14-6 Fluorine series alkyl chloride