ChemicalBook >> CAS DataBase List >>SKI 178
SKI 178
- CAS No.
- 1259484-97-3
- Chemical Name:
- SKI 178
- Synonyms
- SKI 178;SKI-178, 10 mM in DMSO;N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide;N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide , SKI-178;1H-Pyrazole-5-carboxylic acid, 3-(4-methoxyphenyl)-, 2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazide;resistant,SphK,cytotoxic,myeloid,Inhibitor,Apoptosis,leukemia,multi-drug,inhibit,SKI-178,cancer,Sphingosine kinase,SKI178,drug,sensitive,cell,SKI 178
- CBNumber:
- CB04667081
- Molecular Formula:
- C21H22N4O4
- Molecular Weight:
- 394.42
- MDL Number:
- MOL File:
- 1259484-97-3.mol
Last updated:2025-04-29 17:45:46
SKI 178 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24880 | SKI 178 ≥98% | 1259484-97-3 | 5mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 24880 | SKI 178 ≥98% | 1259484-97-3 | 10mg | $155 | 2024-03-01 | Buy |
| TRC | S553003 | SKI178 | 1259484-97-3 | 50mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0012756 | SKI-178 | 1259484-97-3 | 100mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-0012756 | SKI-178 | 1259484-97-3 | 5mg | $75 | 2021-12-16 | Buy |
SKI 178 Chemical Properties,Uses,Production
Uses
SKI 178 is a sphingosine kinase 1 specific small-molecule inhibitor.
in vivo
SKI-178 (20 mg/kg; retro-orbital injection under isoflurane anesthesia) inhibits leukemic progression in the MLL-AF9 model[3].
| Animal Model: | MLL-AF9 mouse model (leukemic mice)[3] |
| Dosage: | 20 mg/kg |
| Administration: | Retro-orbital injection under isoflurane anesthesia; three times per week for 1 and 3 weeks |
| Result: | White blood cell (WBC) counts decreased from their initial 104 cells/μL levels and continued to decline after 3 weeks of treatment until they reached normal levels (~4×103 cells/μL). |
IC 50
SphK1; SphK2
SKI 178 Preparation Products And Raw materials
Raw materials
Preparation Products
SKI 178 Suppliers
Global( 49)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
SKI 178
N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
resistant,SphK,cytotoxic,myeloid,Inhibitor,Apoptosis,leukemia,multi-drug,inhibit,SKI-178,cancer,Sphingosine kinase,SKI178,drug,sensitive,cell,SKI 178
1H-Pyrazole-5-carboxylic acid, 3-(4-methoxyphenyl)-, 2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazide
N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide , SKI-178
SKI-178, 10 mM in DMSO
1259484-97-3