PF-06761281
- CAS No.
- 1854061-19-0
- Chemical Name:
- PF-06761281
- Synonyms
- PF-06761281;PF-06761281 >=97% (HPLC);Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
- CBNumber:
- CB04670535
- Molecular Formula:
- C13H17NO6
- Molecular Weight:
- 283.28
- MDL Number:
- MOL File:
- 1854061-19-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 469.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: 20 mg/mL, clear |
| pka | 3.37±0.28(Predicted) |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 20mg/mL, clear |
| InChI | 1S/C13H17NO6/c1-8-5-9(11(20-2)14-7-8)3-4-13(19,12(17)18)6-10(15)16/h5,7,19H,3-4,6H2,1-2H3,(H,15,16)(H,17,18)/t13-/m1/s1 |
| InChIKey | FGYMJXFSHBLHLW-CYBMUJFWSA-N |
| SMILES | CC1=CC(CC[C@](CC(O)=O)(O)C(O)=O)=C(OC)N=C1 |
| UNSPSC Code | 12161503 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P330+P331+P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
PF-06761281 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0318 | PF-06761281 ≥97% (HPLC) | 1854061-19-0 | 5MG | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | PZ0318 | PF-06761281 ≥97% (HPLC) | 1854061-19-0 | 25MG | $480 | 2026-04-30 | Buy |
| ChemScene | CS-0078677 | PF-06761281 99.52% | 1854061-19-0 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0078677 | PF-06761281 99.52% | 1854061-19-0 | 10mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-0078677 | PF-06761281 99.52% | 1854061-19-0 | 25mg | $433 | 2026-06-04 | Buy |
PF-06761281 Chemical Properties,Uses,Production
Uses
PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.
General Description
PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.
Biochem/physiol Actions
PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.
PF-06761281 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06761281 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
