XESTOSPONGIN C
- CAS No.
- 88903-69-9
- Chemical Name:
- XESTOSPONGIN C
- Synonyms
- XEC;XESTOSPONGIN;ARGUSPONGINE E;XESTOSPONGIN C;(-)-Xestospongin C;PQYOPBRFUUEHRC-HCKQMYSWSA-N;Xestospongin C((-)-Xestospongin C);Xestospongin C, IP3 receptor antagonist;Xestospongin C 4-((1H-Indol-7-yl)carbamoyl)phenyl diethylcarbamate;(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
- CBNumber:
- CB0479020
- Molecular Formula:
- C28H50N2O2
- Molecular Weight:
- 446.71
- MDL Number:
- MFCD01862629
- MOL File:
- 88903-69-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 146-147 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 564.7±35.0 °C(Predicted) |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | film |
| pka | 7.73±0.20(Predicted) |
| color | off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | PQYOPBRFUUEHRC-HCKQMYSWSA-N |
| SMILES | [H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H] |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
XESTOSPONGIN C price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | X2628 | Xestospongin C film | 88903-69-9 | 10μg | $510 | 2026-04-30 | Buy |
| Sigma-Aldrich | X2628 | Xestospongin C film | 88903-69-9 | 50μg | $1850 | 2026-04-30 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 10μg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 50μg | $450 | 2026-04-30 | Buy |
| Cayman Chemical | 64950 | Xestospongin C ≥90% | 88903-69-9 | 100μg | $780 | 2026-04-30 | Buy |
XESTOSPONGIN C Chemical Properties, Uses, Production
Description
Xestospongin C (88903-69-9) is a potent and reversible inhibitor of IP3-mediated Ca2+release, IC50= 358 nM.1Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+and K+currents at a concentration range similar to that at which it inhibits the IP3 receptor. Xestospongin C is a useful tool for probing the involvement of IP3 receptors in cellular signaling.3Cell permeable.
Uses
Xestospongin C is a marine natural product which was first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Xestospongin C antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Inositol phosphates are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores. Xestospongin C blocks the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 μM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700 nM.
Uses
Xestospongin C is a potent, membrane-permeable IP3 receptor blocker.
Definition
ChEBI: An organic heteropentacyclic compound that is isolated from the marine sponge Xestospongia exigua.
General Description
Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge.
Biochem/physiol Actions
Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
storage
Store at -20°C
References
[1] R A WILCOX. New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.[J]. Trends in pharmacological sciences, 1998, 19 11: 467-475. DOI:10.1016/s0165-6147(98)01260-7
[2] HIROSHI OZAKI. Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle[J]. British Journal of Pharmacology, 2009, 137 8: 1207-1212. DOI:10.1038/sj.bjp.0704988
[3] KATHIRVEL KANDASAMY. Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels.[J]. PLoS ONE, 2013: e63465. DOI:10.1371/journal.pone.0063465
XESTOSPONGIN C Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3057 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
View Latest Price from XESTOSPONGIN C manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-28 | Xestospongin C
88903-69-9
|
$518.00 | 10g | TargetMol Chemicals Inc. |
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- Xestospongin C
88903-69-9
- $518.00
- TargetMol Chemicals Inc.
