3-Deazaadenosine (hydrochloride)
- CAS No.
- 86583-19-9
- Chemical Name:
- 3-Deazaadenosine (hydrochloride)
- Synonyms
- 3-Deaza-rA?HCl;3-Deazaadenosine HCl;3-Deazaadenosine (hydrochloride);3-Deazaadenosine hydrochloride, 10 mM in DMSO;1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride;(2R,3R,4S,5R)-2-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride;5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate;HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit
- CBNumber:
- CB04797014
- Molecular Formula:
- C11H15ClN4O4
- Molecular Weight:
- 302.72
- MDL Number:
- MOL File:
- 86583-19-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
3-Deazaadenosine (hydrochloride) price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30969 | 3-Deazaadenosine (hydrochloride) ≥98% | 86583-19-9 | 1mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 30969 | 3-Deazaadenosine (hydrochloride) ≥98% | 86583-19-9 | 5mg | $242 | 2026-04-30 | Buy |
| Cayman Chemical | 30969 | 3-Deazaadenosine (hydrochloride) ≥98% | 86583-19-9 | 10mg | $402 | 2026-04-30 | Buy |
| ChemScene | CS-0069568 | 3-Deazaadenosine hydrochloride ≥98% | 86583-19-9 | 10mg | $352 | 2026-06-04 | Buy |
| ApexBio Technology | B8470 | 3-Deazaadenosine hydrochloride | 86583-19-9 | 1mg | $146 | 2026-05-06 | Buy |
3-Deazaadenosine (hydrochloride) Chemical Properties, Uses, Production
Uses
3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.
Biological Activity
3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with a Ki value of 3.9 μM.
in vitro
3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 μM, respectively.
target
| Target | Value |
| S-adenosylhomocysteine hydrolase (Cell-free assay) | 3.9 μM(Ki) |
IC 50
HIV-1
References
[1] Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. DOI:10.1046/j.1432-1033.2003.03726.x
[2] Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8. DOI:10.1074/jbc.274.27.18981
[3] Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200. DOI:10.1161/CIRCRESAHA.109.194357
3-Deazaadenosine (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
3-Deazaadenosine (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Wuhu Huaren Science and Technology Co., Ltd. | 5842013 18155347026 | xujuan@hdpharm.com | China | 547 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9984 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
View Latest Price from 3-Deazaadenosine (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | 3-Deazaadenosine (hydrochloride)
86583-19-9
|
1G | 97% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-07-27 | 3-Deazaadenosine hydrochloride
86583-19-9
|
$128.00-393.00 | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | 3-Deazaadenosine hydrochloride
86583-19-9
|
$128.00-393.00 | 99.99% | 10g | TargetMol Chemicals Inc. |
-
- 3-Deazaadenosine (hydrochloride)
86583-19-9
- 97%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 3-Deazaadenosine hydrochloride
86583-19-9
- $128.00-393.00
- 99.99%
- TargetMol Chemicals Inc.
-
- 3-Deazaadenosine hydrochloride
86583-19-9
- $128.00-393.00
- 99.99%
- TargetMol Chemicals Inc.
