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3-DEAZAADENOSINE

3-DEAZAADENOSINE structure

CAS No.: 6736-58-9

Chemical Name:: 3-DEAZAADENOSINE

Synonyms: C3-Ado;3-Deaza-rA;NSC 167897;3-DEAZAADENOSINE;3-deazaadenoside;3-Deaza-D-adenosine;3-Deazaadenosine ,98%;3-DEAZAADENOSINE USP/EP/BP;1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine

CBNumber:: CB8680473

Molecular Formula:: C11H14N4O4

Molecular Weight:: 266.25

MDL Number:: MFCD00153951

MOL File:: 6736-58-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:12:14

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3-DEAZAADENOSINE Properties

Melting point	228-229°C
Boiling point	665.7±65.0 °C(Predicted)
Density	1.90±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	H₂O: 10 mg/mL with heating to 60 °C
pka	13.24±0.70(Predicted)
form	Solid
color	White to Off-White
InChI	1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
InChIKey	DBZQFUNLCALWDY-PNHWDRBUSA-N
SMILES	Nc1nccc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
FDA UNII	037V4520IY
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H302+H312-H315-H319-H331-H335
Precautionary statements	P261-P280-P305+P351+P338-P311
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	24/25
RIDADR	2811
WGK Germany	3
HazardClass	6.1(a)
PackingGroup	II
HS Code	29419090
Storage Class	11 - Combustible Solids

3-DEAZAADENOSINE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D8296	3-Deazaadenosine	6736-58-9	5mg	$376	2026-04-30	Buy
Sigma-Aldrich	D8296	3-Deazaadenosine	6736-58-9	10mg	$677	2026-04-30	Buy
Cayman Chemical	9000785	3-Deazaadenosine ≥98%	6736-58-9	1mg	$55	2026-04-30	Buy
Cayman Chemical	9000785	3-Deazaadenosine ≥98%	6736-58-9	5mg	$242	2026-04-30	Buy
Cayman Chemical	9000785	3-Deazaadenosine ≥98%	6736-58-9	10mg	$428	2026-04-30	Buy

Product number	Packaging	Price	Buy
D8296	5mg	$376	Buy
D8296	10mg	$677	Buy
9000785	1mg	$55	Buy
9000785	5mg	$242	Buy
9000785	10mg	$428	Buy

3-DEAZAADENOSINE Chemical Properties, Uses, Production

Description

3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.

Chemical Properties

Bright Yellow Solid

Uses

Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

Biochem/physiol Actions

Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

in vitro

3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].

in vivo

in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].

References

[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).

3-DEAZAADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

3-DEAZAADENOSINE Suppliers

Global Suppliers ( 96)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Wuhu Huaren Science and Technology Co., Ltd.	5842013 18155347026	xujuan@hdpharm.com	China	255	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Nanjing Baifuli Technology Co., Ltd.	25-25-58740604 15951658055	sales@unisyn.cn	China	622	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Nanjing Credit Trading Co.,Ltd	025-52164950	Googlexu_0114@sina.com	China	644	58
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Wuhu Huaren Science and Technology Co., Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Chemsky（shanghai）International Co.,Ltd.	50
Nanjing Baifuli Technology Co., Ltd.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Nanjing Credit Trading Co.,Ltd	58
Shanghai Macklin Biochemical Co.,Ltd.	55
Sigma-Aldrich	80

View Latest Price from 3-DEAZAADENOSINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	3-DEAZAADENOSINE 6736-58-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2020-01-10	3-DEAZAADENOSINE 6736-58-9		1KG	98%; 99%	500g;1kg； 25kg	Career Henan Chemical Co

3-DEAZAADENOSINE
6736-58-9
98%
Henan Aochuang Chemical Co.,Ltd.

3-DEAZAADENOSINE
6736-58-9
$0.01
98%; 99%
Career Henan Chemical Co

3-DEAZAADENOSINE Spectrum

3-DEAZAADENOSINE(6736-58-9)MS

6736-58-9 (3-DEAZAADENOSINE) Related Search:

7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo[4,3-d]pyrimidine monohydrate SANGIVAMYCIN carbocyclic 3-deazaadenosine 7-IODO-7-DEAZAADENOSINE,7-Iodo-7-deazaadenosine, 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 3-DEAZAADENOSINE

7-DEAZAADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT,7-deazaadenosine-5’-monophosphate(7-ch-5’-amp/tump),sodiumsal 2-Amino-4-methoxy-7-(beta-D-2-deoxyribofuranosyl)pyrrolo[2,3-d]pyrimidine TUBERCIDIN 1-deazaadenosine 7-Iodo-2',3'-dideoxy-7-deazaadenosine

7-Ch-cAMP sodium salt 3-Deazaadenosine, [8-3H] 3-Deaza-cadp-ribose 4-Amino-6-chloro-1-β-D-ribofuranosylimidazo[4,5-c]pyridine 5'-methylthio-5'-deoxy-9-deazaadenosine

9-deazaadenosine triphosphate 3-Deazaadenosine 5'-triphosphate 7-Deazaadenosine, [3H]-

1of4

3-DEAZAADENOSINE 4-AMINO-1-[BETA-D-RIBOFURANOSYL]-1H-IMIDAZO[4,5]-PYRIDINE 4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine 1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl- 3-Deaza-D-adenosine NSC 167897 (2R,3R,4S,5R)-2-(4-AMino-1H-iMidazo[4,5-c]pyridin-1-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol 3-Deaza-rA 1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine C3-Ado 3-Deazaadenosine ,98% 4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine 1H-Imidazo[4,5-c]pyridin-4-amine, 1-β-D-ribofuranosyl- 1H-Imidazo[4,5-c]pyridin-4-amine,1-b-D-ribofuranosyl- 3-DEAZAADENOSINE USP/EP/BP 3-deazaadenoside 6736-58-9 Immune Cell Signaling and Blood Immune System Regulation AIDS and Viral Research Reagents BioChemical Cell Signaling and Neuroscience Cell Biology Bases & Related Reagents Inhibitors Nucleotides