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PF-06795071

PF-06795071 Structure
PF-06795071 structure
CAS No.
2075629-81-9
Chemical Name:
PF-06795071
Synonyms
PF-06795071;PF 06795071,PF06795071;(2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate
CBNumber:
CB04840680
Molecular Formula:
C18H17F4N3O3
Molecular Weight:
399.35
MDL Number:
MFCD31813653
MOL File:
2075629-81-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:33
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PF-06795071 Properties

Boiling point 512.6±50.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
form Solid
pka 13.42±0.10(Predicted)
color White to off-white

PF-06795071 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth AID62981 (2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate 2075629-81-9 5mg $1769.6 2026-06-04 Buy
Biosynth AID62981 (2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate 2075629-81-9 10mg $2831.4 2026-06-04 Buy
Biosynth AID62981 (2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate 2075629-81-9 25mg $5308.75 2026-06-04 Buy
Biosynth AID62981 (2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate 2075629-81-9 50mg $8494.5 2026-06-04 Buy
ChemScene CS-0042299 PF-06795071 99.31% 2075629-81-9 5mg $525 2026-06-04 Buy
Product number Packaging Price Buy
AID62981 5mg $1769.6 Buy
AID62981 10mg $2831.4 Buy
AID62981 25mg $5308.75 Buy
AID62981 50mg $8494.5 Buy
CS-0042299 5mg $525 Buy

PF-06795071 Chemical Properties, Uses, Production

Description

PF-06795071 is a potent and selective covalent MAGL inhibitor with MAGL IC50 = 3 nM; FAAH IC50 = 3.1 μM; log D= 3.8; Cb,u/Cp,u = 1.4. PF-06795071 features a novel trifluoromethyl glycol leaving group which confers significant physicochemical property improvements as compared with earlier inhibitor series with more lipophilic leaving groups. The design strategy focused on identifying an optimized leaving group that delivers MAGL potency, serine hydrolase selectivity, and CNS exposure; while simultaneously, reducing LogD, improving solubility, and minimizing chemical lability. PF-06795071 achieves excellent CNS exposure, extended 2-AG elevation effect in vivo, and decreased brain inflammatory markers in response to an inflammatory challenge.

Uses

PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM[1].

References

[1] McAllister LA, et al. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. J Med Chem. 2018 Apr 12;61(7):3008-3026. DOI:10.1021/acs.jmedchem.8b00070

PF-06795071 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-06795071 Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58

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PF-06795071 PF 06795071,PF06795071 (2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate 2075629-81-9