Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>GSK-2593074A)

GSK-2593074A)

GSK-2593074A) Structure
GSK-2593074A) structure
CAS No.
1337531-06-2
Chemical Name:
GSK-2593074A)
Synonyms
GSK'074;GSK-2593074A);GSK2593074A (GSK'074;GSK2593074A,GSK-2593074A;GSK2593074A, 10 mM in DMSO;Ethanone, 1-[5-[4-amino-7-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]-2,3-dihydro-1H-indol-1-yl]-2-phenyl-
CBNumber:
CB04844835
Molecular Formula:
C27H23N5OS
Molecular Weight:
465.57
MDL Number:
MOL File:
1337531-06-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

GSK-2593074A) Properties

Boiling point 807.6±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 41.67 mg/mL (89.50 mM; Need ultrasonic)
form Solid
pka 5.79±0.40(Predicted)
color Light yellow to khaki

GSK-2593074A) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth MDC53106 GSK2593074A 1337531-06-2 25mg $1361.5 2026-06-04 Buy
Biosynth MDC53106 GSK2593074A 1337531-06-2 50mg $1893.5 2026-06-04 Buy
ChemScene CS-0090385 GSK2593074A 99.07% 1337531-06-2 5mg $379 2026-06-04 Buy
ChemScene CS-0090385 GSK2593074A 99.07% 1337531-06-2 10mg $596 2026-06-04 Buy
ChemScene CS-0090385 GSK2593074A 99.07% 1337531-06-2 50mg $1787 2026-06-04 Buy
Product number Packaging Price Buy
MDC53106 25mg $1361.5 Buy
MDC53106 50mg $1893.5 Buy
CS-0090385 5mg $379 Buy
CS-0090385 10mg $596 Buy
CS-0090385 50mg $1787 Buy

GSK-2593074A) Chemical Properties, Uses, Production

Uses

GSK2593074A (GSK’074) is a necroptosis inhibitor with dual targeting ability to both RIP1 and RIP3[1].

in vivo

GSK2593074A (GSK’074; 0.93 mg/kg/day; i.p. injection; 14 or 28 days) is administrated to Apoe-/- mice immediately following pump implantation. Compared to the DMSO group, GSK2593074A-treated mice show significantly alleviated aneurysm formation, reflected by a much smaller aortic dilatation (DMSO 85.39±15.76% vs GSK2593074A 36.28±5.76%; P<0.05) as well as a reduced abdominal aortic aneurysm (AAA) incidence (from 83.3 to 16.7%). GSK2593074A significantly decreases the extent of aortic expansion (DMSO 66.06±9.17% vs GSK2593074A 27.36±8.25%; P<0.05) [1].

Animal Model:Apoe-/- female mice (9-10 months)[1]
Dosage:0.93mg/kg/day; 200μL
Administration:Daily i.p. injection; 14 or 28 days
Result:Inhibited aneurysm formation in mouse models of aneurysms.

References

[1] Zhou T, et al. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell Death Dis. 2019 Mar 6;10(3):226. DOI:10.1038/s41419-019-1468-6

GSK-2593074A) Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-2593074A) Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
SINO High Goal Chemical Technology Co., Ltd. 021-57646680 18306277365 guoxin@chembiobanksh.com China 2819 58
Supplier Advantage
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
cjbscvictory 58
SINO High Goal Chemical Technology Co., Ltd. 58

View Latest Price from GSK-2593074A) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK2593074A pictures 2026-07-27 GSK2593074A
1337531-06-2
 $116.00-455.00 99.99% 10g TargetMol Chemicals Inc.
GSK2593074A pictures 2026-07-27 GSK2593074A
1337531-06-2
 $116.00-455.00 99.99% 10g TargetMol Chemicals Inc.
  • GSK2593074A pictures
  • GSK2593074A
    1337531-06-2
  • $116.00-455.00
  • 99.99%
  • TargetMol Chemicals Inc.
  • GSK2593074A pictures
  • GSK2593074A
    1337531-06-2
  • $116.00-455.00
  • 99.99%
  • TargetMol Chemicals Inc.

GSK-2593074A) Spectrum

GSK-2593074A)(1337531-06-2)1HNMR

1337531-06-2 (GSK-2593074A)) Related Search:

GSK-2593074A) 5-Pyrimidinecarboxamide, 2-[(3S)-3-amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]- 1,6-Naphthyridin-2(1H)-one, 3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino] NA GSK872
ponicidin

1of2

GSK2593074A (GSK'074 GSK-2593074A) GSK'074 Ethanone, 1-[5-[4-amino-7-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl]-2,3-dihydro-1H-indol-1-yl]-2-phenyl- GSK2593074A,GSK-2593074A GSK2593074A, 10 mM in DMSO 1337531-06-2