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HTH-01-091

HTH-01-091 Structure
HTH-01-091 structure
CAS No.
2000209-42-5
Chemical Name:
HTH-01-091
Synonyms
HTH-01-091;HTH 01 091,HTH01091;HTH-01-091, 10 mM in DMSO;Pyrimido[5,4-c]quinolin-2(1H)-one, 9-(3,5-dichloro-4-hydroxyphenyl)-1-[trans-4-[(dimethylamino)methyl]cyclohexyl]-3,4-dihydro-
CBNumber:
CB04844880
Molecular Formula:
C26H28Cl2N4O2
Molecular Weight:
499.43
MDL Number:
MOL File:
2000209-42-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:30
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HTH-01-091 Properties

Boiling point 679.4±55.0 °C(Predicted)
Density 1.327±0.06 g/cm3(Predicted)
pka 6.16±0.25(Predicted)
form Solid
color White to light yellow

HTH-01-091 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0088094 HTH-01-091 99.81% 2000209-42-5 1mg $412 2026-06-04 Buy
ChemScene CS-0088094 HTH-01-091 99.81% 2000209-42-5 5mg $953 2026-06-04 Buy
ChemScene CS-0088094 HTH-01-091 99.81% 2000209-42-5 10mg $1354 2026-06-04 Buy
ApexBio Technology BA3509 HTH-01-091 2000209-42-5 1mg $223 2026-05-06 Buy
ApexBio Technology BA3509 HTH-01-091 2000209-42-5 5mg $558 2026-05-06 Buy
Product number Packaging Price Buy
CS-0088094 1mg $412 Buy
CS-0088094 5mg $953 Buy
CS-0088094 10mg $1354 Buy
BA3509 1mg $223 Buy
BA3509 5mg $558 Buy

HTH-01-091 Chemical Properties,Uses,Production

Description

HTH-01-091 is a selective maternal embryonic leucine zipper kinase (MELK) inhibitor. HTH-01-091 provides a general framework for preclinical target validation.

Uses

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1].

IC 50

DYRK4: 41.8 nM (IC50); RIPK2; PIM1: 60.6 nM (IC50); mTOR: 632 nM (IC50); CDK7: 1230 nM (IC50); PIM2; PIM3

References

[1] Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. DOI:10.7554/eLife.26693

HTH-01-091 Preparation Products And Raw materials

Raw materials

Preparation Products

HTH-01-091 Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 955 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Beijing Keyi Tongda Technology Development Co., Ltd 17743531240 kytd20@sina.com China 1512 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Beijing Keyi Tongda Technology Development Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
Shanghai Amole Biotechnology Co., Ltd. 58

2000209-42-5(HTH-01-091)Related Search:

HTH-01-091 MTI-31 Rapamycin GSK-3326595 GSK872
DRB

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HTH-01-091 HTH 01 091,HTH01091 Pyrimido[5,4-c]quinolin-2(1H)-one, 9-(3,5-dichloro-4-hydroxyphenyl)-1-[trans-4-[(dimethylamino)methyl]cyclohexyl]-3,4-dihydro- HTH-01-091, 10 mM in DMSO 2000209-42-5