felodipine-d5
- CAS No.
- 1242281-38-4
- Chemical Name:
- felodipine-d5
- Synonyms
- Felodipine-d5;Ethoxy-D5-(±)-Felodipine;Felodipine-D5 (Standard);rac Felodipine (Ethoxy-d5);Felodipine D5Q: What is Felodipine D5 Q: What is the CAS Number of Felodipine D5 Q: What is the storage condition of Felodipine D5 Q: What are the applications of Felodipine D5
- CBNumber:
- CB04849214
- Molecular Formula:
- C18H19Cl2NO4
- Molecular Weight:
- 384.25
- MDL Number:
- MOL File:
- 1242281-38-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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felodipine-d5 price More Price(2)
felodipine-d5 Chemical Properties, Uses, Production
Description
(±)-Felodipine-d5 is intended for use as an internal standard for the quantification of (±)-felodipine by GC- or LC-MS. (±)-Felodipine is an inhibitor of L-type calcium channels. It induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM), which highly express L-type calcium channels. (±)-Felodipine is selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 μM, as well as the T-type Cav3.2 channel (IC50 = 6.8 μM). (±)-Felodipine preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively). It decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation when administered intravenously at doses of 30 and 100 nmol/kg.
Uses
Felodipine-d5 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.
References
[1] T FURUKAWA. Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 291 2: 464-473.
[2] J D JOHNSON D A F. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments.[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 226 2: 330-334.
[3] EDWARD PEREZ-REYES I V Amy L Van Deusen. Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 1: 621-627. DOI: 10.1124/jpet.108.145672
[4] LJUNG B. Vascular selectivity of felodipine: experimental pharmacology.[J]. Journal of Cardiovascular Pharmacology, 1990, 15 Suppl 4: S11-6. DOI: 10.1097/00005344-199015004-00003
[5] G R BOLT P R S. Acute systemic and regional hemodynamic effects of felodipine, a new calcium antagonist, in conscious renal hypertensive rabbits.[J]. Journal of Cardiovascular Pharmacology, 1984, 6 4: 707-712. DOI: 10.1097/00005344-198407000-00025
felodipine-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
felodipine-d5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9619 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2470 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 4918 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9894 | 58 |
View Latest Price from felodipine-d5 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Felodipine-D5
1242281-38-4
|
$1190.00 | 10g | TargetMol Chemicals Inc. |
-
- Felodipine-D5
1242281-38-4
- $1190.00
- TargetMol Chemicals Inc.
