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Felodipine

Felodipine structure

CAS No.: 72509-76-3

Chemical Name:: Felodipine

Synonyms: FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82

CBNumber:: CB4300661

Molecular Formula:: C18H19Cl2NO4

Molecular Weight:: 384.25

MDL Number:: MFCD08235033

MOL File:: 72509-76-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-05 19:35:02

Product description	Number	Pack Size	Price
Felodipine solid	F9677	5mg	$145
Felodipine European Pharmacopoeia (EP) Reference Standard	F0030000	100 mg	$175
Felodipine British Pharmacopoeia (BP) Reference Standard	BP777	100MG	$263
Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard	BP758	20MG	$287
Felodipine United States Pharmacopeia (USP) Reference Standard	1269389	300mg	$422
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Felodipine Properties

Melting point	142-145°C
Boiling point	471.5±45.0 °C(Predicted)
Density	1.3506 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	2-8°C
solubility	DMSO: 28 mg/mL
form	solid
pka	2.73±0.70(Predicted)
color	light yellow
Water Solubility	insoluble
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Major Application	pharmaceutical pharmaceutical small molecule
InChI	InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey	RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference	72509-76-3(CAS DataBase Reference)
FDA UNII	OL961R6O2C
NIST Chemistry Reference	Felodipine(72509-76-3)
ATC code	C08CA02
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P301+P312+P330

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 3077 9 / PGIII

WGK Germany

RTECS

US7968700

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Repr. 2
STOT RE 2 Inhalation

NFPA 704

	0
3		0

Felodipine price More Price(100)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F9677	Felodipine solid	72509-76-3	5mg	$145	2026-04-30	Buy
Sigma-Aldrich	F0030000	Felodipine European Pharmacopoeia (EP) Reference Standard	72509-76-3	100 mg	$175	2026-04-30	Buy
Sigma-Aldrich	BP777	Felodipine British Pharmacopoeia (BP) Reference Standard	72509-76-3	100MG	$263	2026-04-30	Buy
Sigma-Aldrich	BP758	Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard	72509-76-3	20MG	$287	2026-04-30	Buy
Sigma-Aldrich	1269389	Felodipine United States Pharmacopeia (USP) Reference Standard	72509-76-3	300mg	$422	2026-04-30	Buy

Product number	Packaging	Price	Buy
F9677	5mg	$145	Buy
F0030000	100 mg	$175	Buy
BP777	100MG	$263	Buy
BP758	20MG	$287	Buy
1269389	300mg	$422	Buy

Felodipine Chemical Properties,Uses,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

vasodilator, Ca channel blocker

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

[1] P A TODD D F. Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders.[J]. Drugs, 1992, 44 2: 251-277. DOI:10.2165/00003495-199244020-00008
[2] T FURUKAWA. Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 291 2: 464-473.

Felodipine synthesis

Synthesis of Felodipine from ETHYL 3-AMINOCROTONATE and Methyl acetoacetate and 2,3-Dichlorobenzaldehyde

Felodipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate Methyl acetoacetate 3-Amino-2-butenoic acid ethyl ester 2,3-Dichlorobenzaldehyde Isopropyl alcohol

Hydrochloric acid NeMadipine B Felodipine 3,5-DiMethyl Ester ETHYL 3-AMINOCROTONATE Pyridine

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Preparation Products

Felodipine Suppliers

Global( 566)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	+8618062405514	ada@ipurechemical.com	China	10224	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-17392587031	1059@dideu.com	China	9984	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5998	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Wuhan Fortuna Chemical Co., Ltd	58

View Lastest Price from Felodipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-19	Felodipine 72509-76-3		1KG	98%-101%	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-04	Felodipine 72509-76-3	$45.00-93.00		99.91%	10g	TargetMol Chemicals Inc.
2026-08-04	Felodipine 72509-76-3	$45.00-93.00		99.91%	10g	TargetMol Chemicals Inc.

Felodipine
72509-76-3
$0.00
98%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

Felodipine
72509-76-3
$45.00-93.00
99.91%
TargetMol Chemicals Inc.

Felodipine
72509-76-3
$45.00-93.00
99.91%
TargetMol Chemicals Inc.

Felodipine Spectrum

Felodipine(72509-76-3)¹HNMR

72509-76-3(Felodipine)Related Search:

ETHANE Dichlorodimethylsilane Dimethyl phthalate Amlodipine maleate Dimethyl carbonate

Amlodipine Dimethyl fumarate Dimethyl sebacate (S)-Amlodipine Dichlorodiphenylsilane

Chlorodimethylphenylsilane Amlodipine Besylate Dihydromyrcenol Dimethyl ether Felodipine Metabolite Lactone

Dimethyl sulfoxide N,N-Dimethylformamide DEHYDRO FELODIPINE-13C4

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,ethylmethylester ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica 4-(2，3-Dichlorophenyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester Fjodil：Hydac P|endil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester CGH-869 Spendil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil Felodipine (300 mg) Felodipine (200 mg) Felodipine/Plendil 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Felodipine, USP Felodipine API 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Clevidipine Butyrate iMpurity Ⅱ 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester Cleviprex Impurity E Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester Clevidipine Impurity E h154/82 modip 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester Felodipin FelodipineUsp25DmfGmp 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil, (RS)-Felodipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester Agon dl-Felodipine Hydac Munobal Splendil Felodipine Plendil Felodipine, 98%, a selective L-type Ca2+ channel blocker Clevidipine Butyrate Impurity 2 Felodipine, 98%, Selective L-type Ca2+ channel blocker Felodipine, ≥98.0% Felodipine CRS Felodipine> odipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester Hot selling high quality Felodipine Felodipine USP/EP/BP Felodipine (CGH869) FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine Felodipine (1269389) Felodipine in methanol Felodipine in Acetonitrile Felodipine, 10 mM in DMSO (4R,12aS)-N-(2,3-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Felodipine