Diethyl 2-anilinomalonate
- CAS No.
- 6414-58-0
- Chemical Name:
- Diethyl 2-anilinomalonate
- Synonyms
- Diethyl 2-(phenylamino);Diethyl 2-anilinomalonate;DIETHYL 2-PHENYLAMINOMALONATE;diethyl 2-anilinopropanedioate;2-Anilinomalonic acid diethyl ester;Diethyl 2-(phenylamino)malonate 95+%;2-Phenylamino-malonic acid diethyl ester;2-(Phenylamino)propanedioic acid diethyl ester;1H-Pyrazole,5-bromo-1-(tetrahydro-2H-pyran-4-yl)-;Propanedioic acid, 2-(phenylamino)-, 1,3-diethyl ester
- CBNumber:
- CB0507130
- Molecular Formula:
- C13H17NO4
- Molecular Weight:
- 251.28
- MDL Number:
- MFCD00122281
- MOL File:
- 6414-58-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
| HS Code | 2922390090 |
Diethyl 2-anilinomalonate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS68228 | Diethyl 2-(phenylamino)malonate 95% | 6414-58-0 | 1g | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR300758 | Diethyl 2-(phenylamino)malonate 95% | 6414-58-0 | 1g | $209 | 2026-06-04 | Buy |
| Activate Scientific | AS68228 | Diethyl 2-(phenylamino)malonate 95% | 6414-58-0 | 5g | $205 | 2026-06-04 | Buy |
| Apolloscientific | OR300758 | Diethyl 2-(phenylamino)malonate 95% | 6414-58-0 | 5g | $802 | 2026-06-04 | Buy |
| Matrix Scientific | 059213 | 2-Phenylamino-malonic acid diethyl ester | 6414-58-0 | 1.00g | $284 | 2026-05-18 | Buy |
Diethyl 2-anilinomalonate Chemical Properties, Uses, Production
Synthesis
685-87-0
6414-58-0
(1) Synthesis of diethyl anilino malonate: Aniline (18.6 g, 0.20 mol) was dissolved in anhydrous benzene (125 mL), followed by the addition of diethyl bromomalonate (23.9 g, 0.10 mol). The reaction mixture was heated to reflux under continuous stirring and maintained for 37 hours. Upon completion of the reaction, the reaction mixture was washed with dilute hydrochloric acid to remove unreacted aniline. The organic layer was separated, washed three times with water and dried with anhydrous magnesium sulfate. Subsequently, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using hexane/ethyl acetate (10:1, v/v) as eluent to afford 7.5 g (30% yield) of diethyl anilino malonate. The product was characterized by nuclear magnetic resonance (NMR) with the following data: 1H NMR (δ, TMS, CCl4): 1.20 (6H, t, J = 7 Hz), 4.20 (4H, q, J = 7 Hz), 4.66 (2H, s, br; changed to 1H after addition of D2O), 6.5-7.3 (5H, m).
References
[1] Patent: US4421914, 1983, A
Diethyl 2-anilinomalonate Preparation Products And Raw materials
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