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NUC-3373

NUC-3373 Structure
NUC-3373 structure
CAS No.
1332837-31-6
Chemical Name:
NUC-3373
Synonyms
Fosifloxuridine nafalbenamide;NUC-3373;nucleotide analog NUC-3373;5-FU analog prodrug NUC-3373;NUC3373(Fosifloxuridine nafalbenamide);phosphoramidate-FUDR-MP prodrug NUC-3373;Fosifloxuridine nafalbenamide, 10 mM in DMSO;L-Alanine, N-(2'-deoxy-5-fluoro-P-1-naphthalenyl-5'-uridylyl)-, phenylmethyl ester;N-(2′-Deoxy-5-fluoro-P-1-naphthalenyl-5′-uridylyl)-L-alanine phenylmethyl ester (ACI);5-FU ANALOG PRODRUG NUC-3373; NUCLEOTIDE ANALOG NUC-3373; PHOSPHORAMIDATE-FUDR-MP PRODRUG NUC-3373
CBNumber:
CB05466546
Molecular Formula:
C29H29FN3O9P
Molecular Weight:
613.54
MDL Number:
MFCD32879310
MOL File:
1332837-31-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
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NUC-3373 Properties

Density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (162.99 mM; Need ultrasonic)
form Solid
pka 7.63±0.10(Predicted)
color White to off-white
InChIKey BIOWRMNRHMERIO-VPUYLDKDNA-N
SMILES O(C1=CC=CC2C=CC=CC1=2)P(=O)(N[C@@H](C)C(=O)OCC1C=CC=CC=1)OC[C@@H]1[C@H](C[C@H](N2C=C(F)C(=O)NC2=O)O1)O |&1:14,28,29,31,r|
FDA UNII 4YO6QT3SZ9

NUC-3373 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth BN179651 NUC-3373 1332837-31-6 1mg $250 2026-06-04 Buy
Biosynth BN179651 NUC-3373 1332837-31-6 5mg $573.5 2026-06-04 Buy
Biosynth BN179651 NUC-3373 1332837-31-6 10mg $917.6 2026-06-04 Buy
ChemScene CS-0078080 Fosifloxuridine nafalbenamide 96.31% 1332837-31-6 5mg $217 2026-06-04 Buy
ChemScene CS-0078080 Fosifloxuridine nafalbenamide 96.31% 1332837-31-6 10mg $303 2026-06-04 Buy
Product number Packaging Price Buy
BN179651 1mg $250 Buy
BN179651 5mg $573.5 Buy
BN179651 10mg $917.6 Buy
CS-0078080 5mg $217 Buy
CS-0078080 10mg $303 Buy

NUC-3373 Chemical Properties, Uses, Production

Uses

Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunoresearch[1][2].

in vivo

Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models[2].

References

[1] Fiona G. McKissock, et al. Abstract 1848: NUC-3373 induces ER stress and the release of damage associated molecular patterns in colorectal cancer cells. Cancer Res August 15 2020 (80) (16 Supplement) 1848.
[2] Essam A. Ghazaly, et al. Abstract B46: NUC-3373: A novel pyrimidine nucleotide analogue that overcomes key cancer drug resistance limiting patient survival. Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) B46.

NUC-3373 synthesis

906670-24-4
50-91-9
1332837-31-6
Synthesis of NUC-3373 from L-Alanine, N-[chloro(1-naphthalenyloxy)phosphinyl]-, phenylmethyl ester and Floxuridine

NUC-3373 Preparation Products And Raw materials

Raw materials

Preparation Products

NUC-3373 Suppliers

Global Suppliers ( 36)
Supplier Tel Email Country ProdList Advantage
Shanghai Fulaiyide Pharmaceutical Technology Co., Ltd 13382092506 15312065189 wang666xt@163.com China 492 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Lianyungang TengFa Biological Technology Co. Ltd 0518-85475186 18705131893 wang666xt@163.com China 351 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 618 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
Shanghai Yanze Chemical Co., Ltd. 15345144255 19901447308 260924549@qq.com China 9989 58
Supplier Advantage
Shanghai Fulaiyide Pharmaceutical Technology Co., Ltd 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Lianyungang TengFa Biological Technology Co. Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
DC Chemicals 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
Shanghai Yanze Chemical Co., Ltd. 58

View Latest Price from NUC-3373 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fosifloxuridine nafalbenamide pictures 2026-06-02 Fosifloxuridine nafalbenamide
1332837-31-6
 $71.00-228.00 95.87% 10g TargetMol Chemicals Inc.

NUC-3373 Spectrum

NUC-3373(1332837-31-6)1HNMR

1332837-31-6 (NUC-3373) Related Search:

3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Sofosbuvir D-Alanine, N-[[P(S),2'R]-2'-cyano-2'-deoxy-2'-Methyl-P-phenyl-5'-cytidylyl]-, 1-Methylethyl ester Sofosbuvir IMpurity B NUC-3373
Methyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

1of2

NUC-3373 5-FU analog prodrug NUC-3373 5-FU ANALOG PRODRUG NUC-3373; NUCLEOTIDE ANALOG NUC-3373; PHOSPHORAMIDATE-FUDR-MP PRODRUG NUC-3373 nucleotide analog NUC-3373 phosphoramidate-FUDR-MP prodrug NUC-3373 L-Alanine, N-(2'-deoxy-5-fluoro-P-1-naphthalenyl-5'-uridylyl)-, phenylmethyl ester NUC3373(Fosifloxuridine nafalbenamide) inhibit,Fosifloxuridine nafalbenamide,anti-cancer,FdUMP,5-FU,5-fluorouracil,fluorodeoxyuridine,FUDR,5-fluorodeoxyuridine,monophosphate,Inhibitor,Thymidylate Synthase benzyl (2S)-2-[({[(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(naphthalen-1-yloxy)phosphoryl)amino]propanoate Benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate Fosifloxuridine nafalbenamide, 10 mM in DMSO Fosifloxuridine nafalbenamide N-(2′-Deoxy-5-fluoro-P-1-naphthalenyl-5′-uridylyl)-L-alanine phenylmethyl ester (ACI) 1332837-31-6 C29H29FN3O9P