SSTR5 antagonist 2 TFA
- CAS No.
- 1254733-98-6
- Chemical Name:
- SSTR5 antagonist 2 TFA
- Synonyms
- SSTR5 antagonist 2 TFA
- CBNumber:
- CB05821383
- Molecular Formula:
- C34H36F4N2O7
- Molecular Weight:
- 660.66
- MDL Number:
- MFCD32062762
- MOL File:
- 1254733-98-6.mol
- MSDS File:
- SDS
SSTR5 antagonist 2 TFA Chemical Properties, Uses, Production
Uses
SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].
in vivo
SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].
| Animal Model: | Rodent diabetic model without risk of hypoglycemia[1]. |
| Dosage: | 10 mg/kg. |
| Administration: | Orally. |
| Result: | Increased both total and active circulating incretin hormone GLP1 levels. |
References
[1] Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. DOI:10.1021/acsmedchemlett.8b00305
SSTR5 antagonist 2 TFA Preparation Products And Raw materials
Raw materials
Preparation Products
SSTR5 antagonist 2 TFA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| RD International Technology Co., Limited | 58 |
| TargetMol Chemicals Inc. | 58 |
