SSTR5 antagonist 2 TFA

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SSTR5 antagonist 2 TFA Basic information
Product Name:SSTR5 antagonist 2 TFA
Synonyms:SSTR5 antagonist 2 TFA
CAS:1254733-98-6
MF:C34H36F4N2O7
MW:660.66
EINECS:
Product Categories:
Mol File:1254733-98-6.mol
SSTR5 antagonist 2 TFA Structure
SSTR5 antagonist 2 TFA Chemical Properties
Safety Information
MSDS Information
SSTR5 antagonist 2 TFA Usage And Synthesis
UsesSSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].
in vivo

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

Animal Model:Rodent diabetic model without risk of hypoglycemia[1].
Dosage:10 mg/kg.
Administration:Orally.
Result:Increased both total and active circulating incretin hormone GLP1 levels.
References[1] Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. DOI:10.1021/acsmedchemlett.8b00305
SSTR5 antagonist 2 TFA Preparation Products And Raw materials
Tag:SSTR5 antagonist 2 TFA(1254733-98-6) Related Product Information
Pasireotide Lanreotide acetate SOMATOSTATIN 28, CYCLIC CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) DOTA-NOC, DOTA-[Nal3]-octreotide D-Tyrosinamide, 4-chloro-N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-phenylalanyl-D-cysteinyl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide