P516-0475
- CAS No.
- 1359627-33-0
- Chemical Name:
- P516-0475
- Synonyms
- P516-0475;[1,2,3]Triazolo[1,5-a]quinoxaline-3-carboxamide, 4,5-dihydro-N-(3-methoxypropyl)-7-methyl-4-oxo-
- CBNumber:
- CB05867327
- Molecular Formula:
- C15H17N5O3
- Molecular Weight:
- 315.33
- MDL Number:
- MOL File:
- 1359627-33-0.mol
- MSDS File:
- SDS
P516-0475 Chemical Properties, Uses, Production
Description
P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
Uses
P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2].
References
[1] Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. DOI:10.1074/jbc.M117.810994
[2] Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. DOI:10.1128/spectrum.05279-22
P516-0475 Preparation Products And Raw materials
Raw materials
Preparation Products
P516-0475 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
