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2-Amino-6-chloro-phenol

2-Amino-6-chloro-phenol Structure
2-Amino-6-chloro-phenol structure
CAS No.
38191-33-2
Chemical Name:
2-Amino-6-chloro-phenol
Synonyms
2-AMino-6-chlorphenol;2-Amino-6-chloro-phenol;2-chloro-6-aMinophenole;3-Chloro-2-hydroxyaniline;phenol, 2-amino-6-chloro-
CBNumber:
CB0655640
Molecular Formula:
C6H6ClNO
Molecular Weight:
143.57
MDL Number:
MFCD07801210
MOL File:
38191-33-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:27
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2-Amino-6-chloro-phenol Properties

Melting point 80-81℃
Boiling point 247℃
Density 1.406
Flash point 103℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form solid
pka 8.28±0.10(Predicted)
color Grey
InChI InChI=1S/C6H6ClNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2
InChIKey QUIIUKFPLUUSGQ-UHFFFAOYSA-N
SMILES C1(O)=C(Cl)C=CC=C1N
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P312-P260-P280
Hazard Codes  Xi
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2922290090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2

2-Amino-6-chloro-phenol price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich TMT00393 2-Amino-6-chlorophenol 1 g $586 2026-04-30 Buy
Apolloscientific OR400447 2-Amino-6-chlorophenol >98% 38191-33-2 1g $21 2026-06-04 Buy
Activate Scientific AS34889 2-Amino-6-chlorophenol  98% 38191-33-2 1g $29 2026-06-04 Buy
Apolloscientific OR400447 2-Amino-6-chlorophenol >98% 38191-33-2 5g $52 2026-06-04 Buy
Activate Scientific AS34889 2-Amino-6-chlorophenol  98% 38191-33-2 5g $101 2026-06-04 Buy
Product number Packaging Price Buy
TMT00393 1 g $586 Buy
OR400447 1g $21 Buy
AS34889 1g $29 Buy
OR400447 5g $52 Buy
AS34889 5g $101 Buy

2-Amino-6-chloro-phenol Chemical Properties,Uses,Production

Uses

2-Amino-6-Chlorophenol is used to synthesize HT2C receptor agonists with high selectivity in functional and binding assays.

Synthesis

2-Chloro-6-nitrophenol

603-86-1

2-AMINO-6-CHLORO-PHENOL

38191-33-2

General procedure for the synthesis of 2-amino-6-chlorophenol from 2-chloro-6-nitrophenol: 2-chloro-6-nitrophenol (1.05 g, 6.03 mmol) was mixed with tin powder (2.32 g, 19.5 mmol) in glacial acetic acid, and the reaction was stirred for 18 hours at 80 °C. After completion of the reaction, the reaction mixture was diluted with deionized water (120 mL) and filtered to remove insoluble material. The filtrate was extracted with ethyl acetate (1 x 100 mL, followed by 2 x 50 mL). The organic phases were combined, washed with saturated saline (3 × 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by rapid column chromatography on silica gel (eluent ratio 2:1 hexane:ethyl acetate) afforded 2-amino-6-chlorophenol as a brown to white crystalline solid (476 mg, 55% yield).1H-NMR (500 MHz, CDCl3) δ 6.73 (dd, J = 1.7, 8.1 Hz, 1H), 6.69 (t, J = 7.8 Hz, 1H ), 6.62 (dd, J = 1.7, 7.7 Hz, 1H), 5.46 (br s, 1H), 3.84 (br s, 2H); 13C-NMR (125 MHz, CDCl3) δ 139.32, 135.73, 121.28, 119.87, 118.31, 114.42; ESI-MS m/z 144 [M +H]+, calculated value of 144 for the molecular formula C6H7ClNO.

References

[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Journal of the Iranian Chemical Society, 2018, vol. 15, # 2, p. 281 - 291
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 7974 - 7985
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3521 - 3525
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3441 - 3449

2-Amino-6-chloro-phenol Preparation Products And Raw materials

Raw materials

2-Chloro-6-nitrophenol Iron

Preparation Products

2-Amino-6-chloro-phenol Suppliers

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Xiezun Chemical Co., Ltd. 025-85629050 13912997845; 179109486@qq.com China 25 60
Shandong RuiYue Biotechnology Co., Ltd. 0531-88581623 18805314509 1456922171@126.com China 63 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Supplier Advantage
Nanjing Xiezun Chemical Co., Ltd. 60
Shandong RuiYue Biotechnology Co., Ltd. 50
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai Topbiochem Technology Co., Ltd 58

View Lastest Price from 2-Amino-6-chloro-phenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-6-chlorophenol pictures 2026-08-25 2-Amino-6-chlorophenol
38191-33-2
 $1.10-9.90 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-AMINO-6-CHLORO-PHENOL pictures 2026-03-20 2-AMINO-6-CHLORO-PHENOL
38191-33-2
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-AMINO-6-CHLORO-PHENOL pictures 2026-02-02 2-AMINO-6-CHLORO-PHENOL
38191-33-2
 10mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd

2-Amino-6-chloro-phenol Spectrum

2-AMINO-6-CHLORO-PHENOL(38191-33-2)1HNMR

38191-33-2(2-Amino-6-chloro-phenol)Related Search:

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phenol, 2-amino-6-chloro- 2-chloro-6-aMinophenole 3-Chloro-2-hydroxyaniline 2-AMino-6-chlorphenol 2-Amino-6-chloro-phenol 38191-33-2