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2-Amino-4,6-dichlorophenol

2-Amino-4,6-dichlorophenol Structure
2-Amino-4,6-dichlorophenol structure
CAS No.
527-62-8
Chemical Name:
2-Amino-4,6-dichlorophenol
Synonyms
2,4-Dichloro-6-amino;2-Amino-4,6-chlorophenol;4,6-Dichloro-α-aminophenol;4,6-Dichloro-2-aminophenol;4,6-Dichloro-o-aminophenol;2,4-DICHLORO-6-AMINOPHENOL;2-amino-4,6-dichloro-pheno;2-Amino-4,6-dichlorophenol;6-AMINO-2,4-DICHLORO PHENOL;3,5-Dichloro-2-hydroxyaniline
CBNumber:
CB8454151
Molecular Formula:
C6H5Cl2NO
Molecular Weight:
178.02
MDL Number:
MFCD00035766
MOL File:
527-62-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:43
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2-Amino-4,6-dichlorophenol Properties

Melting point 97 °C
Boiling point 286.5±40.0 °C(Predicted)
Density 1.2549 (rough estimate)
refractive index 1.5680 (estimate)
RTECS SJ5774000
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 7.85±0.23(Predicted)
form Solid
color Yellow to brown
Merck 14,437
CAS DataBase Reference 527-62-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII ES86DYT9KH
EPA Substance Registry System 2-Amino-4,6-dichlorophenol (527-62-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H302-H312-H332-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P304+P340-P305+P351+P338-P405-P501a
Hazard Note  Irritant
HazardClass  6.1
HS Code  2922290090
NFPA 704
1
2 0

2-Amino-4,6-dichlorophenol price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2246 2-Amino-4,6-dichlorophenol >98.0%(T) 527-62-8 5g $48 2021-12-16 Buy
TCI Chemical A2246 2-Amino-4,6-dichlorophenol >98.0%(T) 527-62-8 25g $158 2021-12-16 Buy
Biosynth FA70348 6-Amino-2,4-dichlorophenol 527-62-8 25g $200 2026-06-04 Buy
Biosynth FA70348 6-Amino-2,4-dichlorophenol 527-62-8 50g $371 2026-06-04 Buy
Biosynth FA70348 6-Amino-2,4-dichlorophenol 527-62-8 100g $643 2026-06-04 Buy
Product number Packaging Price Buy
A2246 5g $48 Buy
A2246 25g $158 Buy
FA70348 25g $200 Buy
FA70348 50g $371 Buy
FA70348 100g $643 Buy

2-Amino-4,6-dichlorophenol Chemical Properties, Uses, Production

Chemical Properties

Off-white or light brown crystals

Uses

2-Amino-4,6-dichlorophenol is used in preparation of novel heteroaryl-substituted Aminoalkyl Azole compounds as pesticides.

General Description

Long needles (from carbon disulfide). Sublimes (at 0.06 mm Hg) at 158-176°F.

Air & Water Reactions

May be sensitive to prolonged exposure to air/or light.

Reactivity Profile

2-AMINO-4,6-DICHLOROPHENOL may react with strong oxidizers and mineral acids or bases .

Fire Hazard

Flash point data for 2-AMINO-4,6-DICHLOROPHENOL are not available. 2-AMINO-4,6-DICHLOROPHENOL is probably combustible.

Synthesis

2,4-Dichloro-6-nitrophenol

609-89-2

2-AMINO-4,6-DICHLOROPHENOL

527-62-8

General procedure for the synthesis of 2,4-dichloro-6-aminophenol from 2,4-dichloro-6-nitrophenol: To a suspension of 2,4-dichloro-6-nitrophenol (60.0 g, 288 mmol) in ethanol (250 mL) and water (250 mL) was added sodium bisulfite (251 g, 1.44 mol) in batches. The reaction mixture was stirred at 65 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently diluted with saturated aqueous sodium bicarbonate (500 mL) and extracted with ethyl acetate (200 mL x 4). The extracted organic layer was washed with brine and then dried with anhydrous magnesium sulfate. The dried organic layer was filtered and concentrated in vacuum. The residue was purified by silica gel EPO fast column chromatography with an eluent of 0-50% ethyl acetate/hexane gradient mixture. The target fractions were collected and the filtrate was concentrated in vacuum to give a solid product. The solid was washed with hexane to give a final 2,4-dichloro-6-aminophenol (30.6 g, 172 mmol, 60% yield) as a colorless powder. The product was confirmed by 1H NMR (CDCl3): δ 3.92 (s, 2H), 5.36 (s, 1H), 6.59 (d, J = 2.1Hz, 1H), 6.71 (d, J = 2.1Hz, 1H). Results of mass spectrometry analysis: MS Calcd.: 177; MS measured value: 178 (M + H).

Purification Methods

Crystallise the phenol from CS2 or *benzene. It sublimes at 0.06mm. The hydrochloride has m 280-285o from EtOH. [Meyer Helv Chim Acta 41 1890 1958, Beilstein 13 II 185, 13 III 856, 13 IV 889.]

References

[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1923 - 1928
[3] Patent: WO2008/51533, 2008, A2. Location in patent: Page/Page column 79-80
[4] Patent: US2002/156081, 2002, A1
[5] Patent: US6921763, 2005, B2

2-Amino-4,6-dichlorophenol Preparation Products And Raw materials

Raw materials

2,4-Dichloro-6-nitrophenol Ethanol Sodium dithionite Water

Preparation Products

sodium 5-[(3,5-dichloro-2-hydroxyphenyl)azo]-4-[(ethoxycarbonyl)amino]-6-hydroxynaphthalene-2-sulphonate Oxyclozanide 5,7-Dichloro-benzooxazole-2-thiol

2-Amino-4,6-dichlorophenol Suppliers

Global Suppliers ( 194)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Beijing Eternalchem Co,. Ltd. 010-59484199 18611897322;18611897322; sales@eternalchem.com China 1993 60
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
Beijing Eternalchem Co,. Ltd. 60
Syntechem Co.,Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Sphchem Co., Ltd. 55
Shanghai civi chemical technology co.,Ltd 52

View Latest Price from 2-Amino-4,6-dichlorophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4,6-DICHLOROPHENOL pictures 2026-09-16 2-AMINO-4,6-DICHLOROPHENOL
527-62-8
 0.99 RongNa Biotechnology Co.,Ltd
2-Amino-4,6-dichlorophenol pictures 2026-06-30 2-Amino-4,6-dichlorophenol
527-62-8
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Amino-4,6-dichlorophenol pictures 2025-06-20 2-Amino-4,6-dichlorophenol
527-62-8
 1KG 0.99 1000kg Hebei Yanxi Chemical Co., Ltd.

527-62-8 (2-Amino-4,6-dichlorophenol) Related Search:

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4,6-Dichloro-2-aminophenol 4,6-Dichloro-α-aminophenol 3-Amino-2-hydroxy-1,5-dichlorbenzene 2-Amino-4,6-chlorophenol 2,4-DICHLORO-6-AMINOPHENOL 99% 4,6-Dichloro-o-aminophenol Phenol, 2-amino-4,6-dichloro- 2,4-Dichloro-6-amino 3,5-Dichloro-2-hydroxyaniline 6-AMINO-2,4-DICHLORO PHENOL 2,4-DICHLORO-6-AMINOPHENOL 3,5-Dichloro-6-hydroxyaniline, 98+% 3,5-Dichloro-6-hydroxyaniline 2-amino-4,6-dichloro-pheno 2-Amino-4,6-dichlorophenol > 2-Amino-4,6-dichlorophenol, ≥ 95.0% 2-Amino-4,6-dichlorophenol, CAS 527-62-8 2-Amino-4,6-dichlorophenol 527-62-8 C6H5NOCl2 C6H5Cl2NO Aromatic Phenols