2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
- CAS No.
- 532967-21-8
- Chemical Name:
- 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
- Synonyms
- CAS:532967-21-8;3,5-Difluoro-4-formylphenol;6-difluoro-4-hydroxybenzaldehyde;2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2,6-difluoro-4-hydroxy-;2,6-Difluoro-4-hydroxybenzaldehyde,95%;2,6-Difluoro-4-hydroxybenzaldehyde 98%;2,6-Difluoro-4-hydroxybenzaldehyde ,97%;Benzaldehyde, 2,6-difluoro-4-hydroxy- (9CI);2,6-difluoro-4-hydroxybenzaldehyde2,6-difluoro-4-hydroxybenzaldehyde
- CBNumber:
- CB0687128
- Molecular Formula:
- C7H4F2O2
- Molecular Weight:
- 158.1
- MDL Number:
- MFCD07772042
- MOL File:
- 532967-21-8.mol
- MSDS File:
- SDS
| Melting point | 179-182℃ |
|---|---|
| Boiling point | 252.6±35.0 °C(Predicted) |
| Density | 1.464±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder |
| pka | 5.80±0.23(Predicted) |
| color | Off-white to cream |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 532967-21-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20-36/37/38 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29124990 | |||||||||
| NFPA 704 |
|
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D447438 | 2,6-Difluoro-4-hydroxybenzaldehyde | 532967-21-8 | 1g | $125 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2615-3-35 | 2,6-Difluoro-4-hydroxybenzaldehyde | 532967-21-8 | 1g | $128 | 2021-12-16 | Buy |
| Apolloscientific | PC9940 | 2,6-Difluoro-4-hydroxybenzaldehyde 98% | 532967-21-8 | 250mg | $25 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2615-3-35 | 2,6-Difluoro-4-hydroxybenzaldehyde | 532967-21-8 | 250mg | $40 | 2021-12-16 | Buy |
| Apolloscientific | PC9940 | 2,6-Difluoro-4-hydroxybenzaldehyde 98% | 532967-21-8 | 5g | $180 | 2021-12-16 | Buy |
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Chemical Properties,Uses,Production
Chemical Properties
Brown to red powder
Synthesis
68-12-2
532967-21-8
General procedure for the synthesis of 2,6-difluoro-4-hydroxybenzaldehyde from N,N-dimethylformamide: At -78 °C, sec-butyllithium (1.3 M cyclohexane solution, 53 mL, 69.3 mmol) was slowly added to intermediates 19,1-(tert-butyldimethylsilyl)oxy-3,5-difluorobenzene (15.3 g, 62.6 mmol) and TMEDA (10.5 mL, 69.3 mmol) in a solution of tetrahydrofuran (200 mL) and stirred for 30 min at a maintained temperature of -78 °C. Subsequently, DMF (5.33 mL, 69.3 mmol) was added at the same temperature and stirring was continued for 1.5 hours. After the reaction was completed, 10% aqueous hydrochloric acid was added to adjust the pH to 4-5 (~200 mL) and then stirred at room temperature for 12 hours. The aqueous layer was extracted with ethyl acetate (200 mL) and the organic layer was separated. The organic layer was washed sequentially with saturated aqueous sodium bicarbonate, added sodium bicarbonate followed by water, and then adjusted the pH to 3-4 with hydrochloric acid, separated the organic layer, washed with brine, dried with anhydrous sodium sulfate, and finally evaporated in vacuum to obtain 2,6-difluoro-4-hydroxybenzaldehyde (9.7 g, 97% yield, 61.3 mmol) as a white solid.1H NMR (DMSO-d6) data: δ 11.54 (br.s, 1H, OH), 10.00 (s, 1H, CHO), 6.50-6.57 (m, 2H, Ar-H).
References
[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 136-137
2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12580 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12887 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3786 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
View Lastest Price from 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
532967-21-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
532967-21-8
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-01-03 | 2,6-Difluoro-4-hydroxybenzaldehyde
532967-21-8
|
US $0.00-0.00 / KG | 10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
532967-21-8
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE
532967-21-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,6-Difluoro-4-hydroxybenzaldehyde
532967-21-8
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
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