ChemicalBook >> CAS DataBase List >>N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine structure

CAS No.: 110-18-9

Chemical Name:: N,N,N',N'-Tetramethylethylenediamine

Synonyms: TMEDA;TEMED;TETRAMETHYLETHYLENEDIAMINE;N1,N1,N2,N2-tetraMethylethane-1,2-diaMine;TMED;1,4-DIAMINOBUTANE;TD;1,2-BIS(DIMETHYLAMINO)ETHANE;2,5-DiMethyl-2,5-diazahexane;N,N,N',N'-TETRAMETHYLENEDIAMINE

CBNumber:: CB2446761

Molecular Formula:: C6H16N2

Molecular Weight:: 116.2

MDL Number:: MFCD00008335

MOL File:: 110-18-9.mol

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	8.08742	5ml	$33.2
N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	8.08742	250ML	$57.4
N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	8.08742	1L	$184
N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	411019	1l	$443.65
N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	411019	2l	$851.2
More product size

Request For Quotation

N,N,N',N'-Tetramethylethylenediamine Properties

Melting point	−55 °C(lit.)
Boiling point	120-122 °C(lit.)
Density	0.775 g/mL at 20 °C(lit.)
vapor density	4 (vs air)
vapor pressure	21 hPa (20 °C)
refractive index	n20/D 1.4179(lit.)
Flash point	50 °F
storage temp.	Store below +30°C.
solubility	H₂O: 10 mg/mL at 20 °C, clear, colorless
pka	10.40, 8.26(at 25℃)
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	0.777 (20/4℃)
Odor	Amine like
PH	8.0-8.5 (0.1g/l, H2O, 20℃)
explosive limit	1-9%(V)
Water Solubility	miscible
Sensitive	Hygroscopic
Merck	14,9134
BRN	1732991
Stability	Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.
InChIKey	DMQSHEKGGUOYJS-UHFFFAOYSA-N
LogP	-0.13 at 20.2℃
Indirect Additives used in Food Contact Substances	N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE
CAS DataBase Reference	110-18-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	K90JUB7941
NIST Chemistry Reference	1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)
EPA Substance Registry System	Tetramethylethylenediamine (110-18-9)
UNSPSC Code	41105319
NACRES	NC.01

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06

Signal word

Danger

Hazard statements

H225-H301+H331-H314

Precautionary statements

P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

F,C,Xi

Risk Statements

11-20/22-34-20/21/22

Safety Statements

16-26-36/37/39-45

RIDADR

UN 2372 3/PG 2

WGK Germany

RTECS

KV7175000

3-8-10-34

Autoignition Temperature

145 °C

Hazard Note

Irritant

TSCA

Yes

HazardClass

PackingGroup

HS Code

29212900

Hazardous Substances Data

110-18-9(Hazardous Substances Data)

Limited Quantities

1.0 L (0.3 gallon) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	3
3		0

N,N,N',N'-Tetramethylethylenediamine price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.08742	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	110-18-9	5ml	$33.2	2025-07-31	Buy
Sigma-Aldrich	8.08742	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	110-18-9	250ML	$57.4	2025-07-31	Buy
Sigma-Aldrich	8.08742	N,N,N′,N′-Tetramethyl ethylenediamine for synthesis	110-18-9	1L	$184	2025-07-31	Buy
Sigma-Aldrich	411019	N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	110-18-9	1l	$443.65	2025-07-31	Buy
Sigma-Aldrich	411019	N,N,N′,N′-Tetramethyl ethylenediamine ≥99.5%, purified by redistillation	110-18-9	2l	$851.2	2025-07-31	Buy

Product number	Packaging	Price	Buy
8.08742	5ml	$33.2	Buy
8.08742	250ML	$57.4	Buy
8.08742	1L	$184	Buy
411019	1l	$443.65	Buy
411019	2l	$851.2	Buy

N,N,N',N'-Tetramethylethylenediamine Chemical Properties,Uses,Production

Chemical Properties

Colorless to slightly yellow liquid

Uses

N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent. It is also used for the separation of proteins or nucleic acids. Further, it is employed as a ligand for metal ions like zinc and copper. It is actively involved in the formation of anionic organometallic complex.

Definition

ChEBI: N,N,N',N'-tetramethylethylenediamine is an ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. It has a role as a chelator and a catalyst.

Application

N,N,N',N'-Tetramethylethylenediamine (TMEDA) is a highly efficient catalyst for the Baylis-Hillman reaction, outperforming the most widely used catalyst DABCO. TMEDA can catalyze the Baylis-Hillman reaction of aromatic aldehydes with various active olefins.^[1]

General Description

1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .

Reactivity Profile

N,N,N',N'-Tetramethylethylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Purification Methods

Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]

References

[1] SANHU ZHAO Zhao bin C. The N,N,N′,N′–Tetramethylethylenediamine Mediated Baylis‐Hillman Reaction[J]. Synthetic Communications, 2005, 35 1: 121-127. DOI:10.1081/SCC-200046521.

N,N,N',N'-Tetramethylethylenediamine synthesis

Synthesis of N,N,N',N'-Tetramethylethylenediamine from Dimethylamine and Acetylene

N,N,N',N'-Tetramethylethylenediamine Preparation Products And Raw materials

Raw materials

Oxalic acid dihydrate Ethylenediamine Formaldehyde Formic acid Paraformaldehyde

Preparation Products

4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene 2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID 1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride, 2-(TRIFLUOROMETHOXY)BENZAMIDE 1,1'-FERROCENEDICARBOXALDEHYDE

1 1'-BIS(DIPHENYLPHOSPHINO)FERROCENE 5-ETHYL-2-FURALDEHYDE 5-AMINO-2-METHOXY-ISONICOTINIC ACID 3-METHYLBENZO[B]THIOPHENE 1,1'-Bis(diphenylphosphino)ferrocene

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID (OXYDI-2,1-PHENYLENE)BIS(DIPHENYLPHOSPHINE) 1,1'-Bis(di-tert-butylphosphino)ferrocene 2-ACETYL-3-METHYLBENZO[B]THIOPHENE 2-MORPHOLINO-5-(TRIFLUOROMETHYL)BENZALDEHYDE

N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE 5-ACETYL-2-THIOPHENECARBALDEHYDE 2,3-Dimethoxyphenylboronic acid 1,1'-DIMETHYLFERROCENE 1-DIPHENYLPHOSPHINO-1'-(DI-TERT-BUTYLPH&

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 1,1'-Bis(diisopropylphosphino)ferrocene 4,6-DIMETHYLDIBENZOTHIOPHENE 5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID 3-METHYLBENZO[B]THIOPHENE-2-CARBOXALDEHYDE

5-AMINO-2-FLUORO-ISONICOTINIC ACID

1of6

N,N,N',N'-Tetramethylethylenediamine Suppliers

Global( 736)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zouping mingyuan import & export trading co., ltd	+86-0543-2240078 +8618364991597	myzhao793@163.com	China	981	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9644	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Huizhili (Changzhou) Life Technology Co., Ltd	+8613906110102	13906110102@139.com	China	16	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8767	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5249	58
Hebei Dangtong Import and export Co LTD	+86-86-4001020630 +8619831957301	admin@hbdangtong.com	China	1000	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21610	55

Supplier	Advantage
Zouping mingyuan import & export trading co., ltd	58
changzhou huayang technology co., ltd	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Aladdin Scientific	58
Huizhili (Changzhou) Life Technology Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Dangtong Import and export Co LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55

The brief introduction of N,N,N',N'-Tetramethylethylenediamine
TMEDA is widely employed as a ligand for metal ions. It forms stable complexes with metal halides, e.g., zinc chloride and cop....
Apr 25，2024

N,N,N',N'-Tetramethylethylenediamine: Synthesis, application and precautions
N,N,N',N'-Tetramethylethylenediamine is widely employed both as a ligand for metal ions and as a catalyst in organic polymeris....
May 24，2023

What is N,N,N',N'-Tetramethylethylenediamine?
N,N,N',N'-Tetramethylethylenediamine is widely employed both as a ligand for metal ions and as a catalyst in organic polymeris....
Mar 1，2021

View Lastest Price from N,N,N',N'-Tetramethylethylenediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-11	N,N,N',N'-Tetramethylethylenediamine 110-18-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-11-26	N,N,N',N'-Tetramethylethylenediamine 110-18-9	US $0.00 / kg	200kg	99%	EX:1tons	Huizhili (Changzhou) Life Technology Co., Ltd
2025-11-18	N,N,N',N'-Tetramethylethylenediamine 110-18-9	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

N,N,N',N'-Tetramethylethylenediamine
110-18-9
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

N,N,N',N'-Tetramethylethylenediamine
110-18-9
US $0.00 / kg
99%
Huizhili (Changzhou) Life Technology Co., Ltd

N,N,N',N'-Tetramethylethylenediamine
110-18-9
US $1.10 / g
99.00%
Dideu Industries Group Limited

N,N,N',N'-Tetramethylethylenediamine Spectrum

N,N,N',N'-Tetramethylethylenediamine(110-18-9)MS N,N,N',N'-Tetramethylethylenediamine(110-18-9)¹HNMR N,N,N',N'-Tetramethylethylenediamine(110-18-9)¹³CNMR N,N,N',N'-Tetramethylethylenediamine(110-18-9)IR1 N,N,N',N'-Tetramethylethylenediamine(110-18-9)Raman

110-18-9(N,N,N',N'-Tetramethylethylenediamine)Related Search:

N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine 3-Dimethylaminopropylamine Triacetonediamine N,N-Dimethylethylenediamine ETHANE

N-(1-Naphthyl)ethylenediamine dihydrochloride 2-(2-Aminoethylamino)ethanol Pinacol 2-Aminoethyl(ethyl)amine N-METHYLETHYLENEDIAMINE

Hexafluoroethane Tetramethylammonium bromide Tetrabutylammonium hydrogen sulfate Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate Tetrabutylammonium bromide

2,2,6,6-Tetramethyl-4-piperidinol N,N,N',N'-Tetramethyl-1,6-hexanediamine Actinomycin D

1of4

N1,N1,N2,N2-tetraMethylethane-1,2-diaMine N,N,N',N'-Tetramethylethane-1,2-diamine, electrophoresis grade 1,2-EthanediaMine,N1,N1,N2,N2-tetraMethyl- Four MethylEthylenediaMine N,N,N',N'-TetraMethylethylenediaMine >=99.5%, purified by redistillation N,N,N',N'-TetraMethylethylenediaMine ReagentPlus(R), 99% (CH3)2NCH2CH2N(CH3)2 1,2-Diaminoethane, N,N,N',N'-tetramethyl- 1,2-Ethanediamine,N,N,N’,N’-tetramethyl- 2-Ethanediamine,N,N,N’,N’-tetramethyl-1 dimethyl(2-(dimethylamino)ethyl)amine Dimethyl[2-(dimethylamino)ethyl]amine Ethylenediamine, N,N,N',N'-tetramethyl- N,N,N',N'-Tetramethyl-1,2-ethanediamine N,N,N',N'-Tetramethylethanediamine N,N,N',N'-Tetramethylethenediamine N,N,N’,N’-Tetramethyl-1,2-ethanediamine n,n,n’,n’-tetramethyl-2-ethanediamine N,N,N’,N’-Tetramethyl-ethane-1,2-diamine 1,2-Bis(dimethylamino)ethane~TEMED~TMEDA N,N,N,N-TetramethylAV12537 NNNN-Tetramethyl-ethylenediamine 99+ % (GLC) temed electrophoresis TEMED N,N,N,N-Tetramethylethylenediamine TEMED, Molecular Biology Grade N,N,N,N-Tetramethylethylenediamine, Molecular Biology Grade CN,N,N',N'-Tetramethylethylenediamine N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, AB SOLUTE N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, RE DISTILLED, 99.5+% TEMED MOLECULAR BIOLOGY REAGENT N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, FO R MOL. BIOLOGY N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, FO R ELECTROPHORESIS TEMED ELECTROPHORESIS REAGENT N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, REAGENTPLUS, 99% N N N' N'-TETRAMETHYLETHYLENEDIAMINE R& N,N,N',N'-Tetramethylethylenediamine>99% 1,2-did(dimethylamino)ethane N,N,N',N'-Tetramethylethylenediamine, extra pure, 99% N,N,N',N'-Tetramethylethylenediamine, For electrophoresis, for biochemistry, 99% N,N,N',N'-Tetramethylethylenediamine,99%TMEDA TMEDA TEMED (N,N,N'',N''-TETRAMETHYLETHYLENDIAMINE) N,N,N′,N′-Tetramethylethylendiamin N,N,N',N'-TETRAMETHYL ETHYLENEDIAMINE pure N,N,N',N'-Tetramethylethylenediamine, 99%, extra pure Temed(N,N,NTetramethylethyleneDiamene) N,N,N',N'-Tetramethylethylenediamine,99%,forbiochemistry,For electrophoresis N,N,N',N'-Tetramethylethylenediamine Vetec(TM) reagent grade, >=99% AZINPHOS METHYL NEAT N,N,N′,N′-Tetramethylethylenediamine(TEMED、TMEDA) N,N,N'',N''-TETRAMETHYLETHYLENEDIAMI N,N,N1,N1-Tetramethylethylenediamine n,n,ni,ni-tetramethylethylenediamine Propamine D propamined Tetrameen Tetramethyldiaminoethane BIS(DIMETHYLAMINO)ETHANE 1,2-BIS(DIMETHYLAMINO)ETHANE