Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4,4-Difluoroaminoethylpiperidine

4,4-Difluoroaminoethylpiperidine

4,4-Difluoroaminoethylpiperidine Structure
4,4-Difluoroaminoethylpiperidine structure
CAS No.
605659-03-8
Chemical Name:
4,4-Difluoroaminoethylpiperidine
Synonyms
4,4-Difluoroaminoethylpiperidine;4,4-Difluoropiperidine-1-ethanamine;4,4-DIFLUORO-1-PIPERIDINEETHANAMINE;1-Piperidineethanamine,4,4-difluoro-;2-(4,4-DIFLUOROPIPERIDIN-1-YL)ETHYLAMINE;2-(4,4-Difluoropiperidin-1-yl)ethanamine;1-Piperidineethanamine,4,4-difluoro-(9CI)
CBNumber:
CB0693608
Molecular Formula:
C7H14F2N2
Molecular Weight:
164.2
MDL Number:
MFCD04119705
MOL File:
605659-03-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:27
Request For Quotation

4,4-Difluoroaminoethylpiperidine Properties

storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
RIDADR  UN2735
HazardClass  8
HS Code  2933599590
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

4,4-Difluoroaminoethylpiperidine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 291706 2-(4,4-Difluoropiperidin-1-yl)ethanamine 605659-03-8 100.00mg $48 2026-05-19 Buy
Matrix Scientific 291706 2-(4,4-Difluoropiperidin-1-yl)ethanamine 605659-03-8 250.00mg $78 2026-05-19 Buy
Matrix Scientific 291706 2-(4,4-Difluoropiperidin-1-yl)ethanamine 605659-03-8 1.00g $186 2026-05-19 Buy
Synthonix D61738 2-(4,4-Difluoropiperidin-1-yl)ethanamine >98% 605659-03-8 100mg $50 2026-05-06 Buy
Synthonix D61738 2-(4,4-Difluoropiperidin-1-yl)ethanamine >98% 605659-03-8 250mg $80 2026-05-06 Buy
Product number Packaging Price Buy
291706 100.00mg $48 Buy
291706 250.00mg $78 Buy
291706 1.00g $186 Buy
D61738 100mg $50 Buy
D61738 250mg $80 Buy

4,4-Difluoroaminoethylpiperidine Chemical Properties, Uses, Production

Synthesis

(4,4-DIFLUOROPIPERIDIN-YL)ACETONITRILE

824413-96-9

4,4-DIFLUOROAMINOETHYLPIPERIDINE

605659-03-8

At room temperature, 2-(4,4-difluoropiperidin-1-yl)acetonitrile (480 mg, 3.0 mmol) was dissolved in tetrahydrofuran (THF, 10 mL), followed by addition of lithium aluminum hydride (LAH, 228 mg, 6.0 mmol). The reaction mixture was stirred overnight at room temperature and then quenched by slow addition of water (10 mL) and 15% aqueous sodium hydroxide (10 mL). The resulting mixture was filtered and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (dichloromethane: methanol = 10:1) to afford 2-(4,4-difluoropiperidin-1-yl)ethylamine (400 mg, 80% yield) as a yellow oil.

References

[1] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 131
[2] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 00534; 00536
[3] Patent: US2006/58308, 2006, A1. Location in patent: Page/Page column 46
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 497 - 501
[5] Patent: WO2015/150449, 2015, A2. Location in patent: Page/Page column 204

4,4-Difluoroaminoethylpiperidine Preparation Products And Raw materials

Raw materials

(4,4-Difluoropiperidin-yl)acetonitrile Lithium Aluminum Hydride Tetrahydrofuran

Preparation Products

4,4-Difluoroaminoethylpiperidine Suppliers

Global Suppliers ( 41)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4976 55
BTC Pharmaceutical CO. Ltd +86-15716293042 15716293042 info@btcpharm.com China 822 55
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3917 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 sales@changyanchem.cn China 4998 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
ShangHai Angti Biotechnology Co., Ltd. 55
BTC Pharmaceutical CO. Ltd 55
TaiChem Taizhou Limited 58
Shanghai Changyan Chem & Tech Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Amadis Chemical Company Limited 58
Aikon International Limited 58

4,4-Difluoroaminoethylpiperidine Spectrum

4,4-DIFLUOROAMINOETHYLPIPERIDINE(605659-03-8)1HNMR

605659-03-8 (4,4-Difluoroaminoethylpiperidine) Related Search:

4,4-Difluoroaminoethylpiperidine 4,4-Difluoropiperidine 2-(4,4-difluoropiperidin-1-yl)ethan-1-amine dihydrochloride 1-Piperidineacetamide, 4,4-difluoro- 5-(4,4-Difluoropiperidin-1-yl)-pentylamine
1-Piperidineethanamine, 4,4-difluoro-α-methyl-

1of2

2-(4,4-DIFLUOROPIPERIDIN-1-YL)ETHYLAMINE 1-Piperidineethanamine,4,4-difluoro- 1-Piperidineethanamine,4,4-difluoro-(9CI) 2-(4,4-Difluoropiperidin-1-yl)ethanamine 4,4-DIFLUORO-1-PIPERIDINEETHANAMINE 4,4-Difluoropiperidine-1-ethanamine 4,4-Difluoroaminoethylpiperidine 605659-03-8 C7H14F2N2 PIPERIDINE AMINETERTIARY HALIDE