Curcumol
- CAS No.
- 4871-97-0
- Chemical Name:
- Curcumol
- Synonyms
- (-)-Curcumol;Curcumo;CURCUMOL;Curcumae;Curcumol-RM;(?)-Curcumol;Curcumol USP/EP/BP;Curcumol (Standard);5,8-Epoxy-10(14)-guaien-8-ol;(3S,3aS,5S,6R,8aS)-5-Isopropyl-3-methyl-8-methyleneoctahydro-6H-3a,6-epoxyazulen-6-ol
- CBNumber:
- CB0701727
- Molecular Formula:
- C15H24O2
- Molecular Weight:
- 236.35
- MDL Number:
- MFCD00272163
- MOL File:
- 4871-97-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 141.0 to 145.0 °C |
|---|---|
| Boiling point | 334.5±42.0 °C(Predicted) |
| Density | 1.06±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility |
DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM) Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM) |
| pka | 13.02±0.60(Predicted) |
| form | Solid |
| color | White to Light yellow |
| Major Application | food and beverages |
| InChI | InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1 |
| InChIKey | QRMPRVXWPCLVNI-YYFQZIEXSA-N |
| SMILES | C1[C@]2([H])[C@@]3(O[C@](O)(CC2=C)[C@H](C(C)C)C3)[C@@H](C)C1 |
| LogP | 3.276 (est) |
| CAS DataBase Reference | 4871-97-0 |
| FDA UNII | 9190RTN07X |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| HS Code | 29321900 |
| Storage Class | 13 - Non Combustible Solids |
Curcumol price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 36236 | ( ?)-Curcumol analytical standard | 4871-97-0 | 10mg | $269 | 2022-05-15 | Buy |
| TCI Chemical | C3439 | Curcumol >98.0%(GC) | 4871-97-0 | 10mg | $102 | 2026-04-30 | Buy |
| TCI Chemical | C3439 | Curcumol >98.0%(GC) | 4871-97-0 | 50mg | $307 | 2026-04-30 | Buy |
| Cayman Chemical | 26849 | Curcumol ≥95% | 4871-97-0 | 10mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 26849 | Curcumol ≥95% | 4871-97-0 | 25mg | $270 | 2026-04-30 | Buy |
Curcumol Chemical Properties, Uses, Production
Background
Curcumol, a bioactive sesquiterpenoid, has been isolated from numerous plants of family Zingiberaceae. These plants are mostly found in Southeast Asia, China, Indonesia, India, Peru, and West Indies. Curcumol has been isolated from C. longa which is an imperative species of the genus Curcuma and is generally known as common turmeric. Curcumol was also extracted from the rhizome of C. aeruginosae that is effective for antiinflammatory and antioxidant activities. C. aromatic, a well-known natural source of curcumol, has been reported for its antitumor and antimicrobial activities. C. kwangsiensis and C. phaeocaulis are advantageous for their antiproliferative activities against various cancer types. Dried roots of C. zedoary enriched with curcumol are documented for their effective anticancer and antiinflammatory properties. Rhizome of various Curcuma species, a rich source of curcumol, serves as antimicrobial, antifibrotic, and anticancer agent. Besides them, curcumol has also been isolated from the roots of Astragali radix, C. rhizoma, and Fructus gardenia which are traditionally used as anticancer agents. 
The above figure provides natural sources of curcumol including Astragali radix, C. aeruginosae, C. aromatica, C. kwangsiensis, C. longa, C. phaeocaulis, C. wenyujin, C. zedoary, Fructus gardenia, and C. trichosantha G[1].
Description
Curcumol, a bioactive sesquiterpenoid, has been isolated from various plants from Zingiberaceae. In recent years, curcumol attracts much attention due to its multiple biological activities and few negative effects. Accumulated studies prove that curcumol shows beneficial effects in protecting against inflammation, oxidative stress, cancer, neurodegeneration and microbial infection. Besides, a number of signaling pathways such as MAPK, PI3K/Akt and NF-κB are influenced by curcumol[2].
Chemical Properties
White crystalline powder, easily soluble in chloroform, ether, soluble in ethanol, slightly soluble in petroleum ether, almost insoluble in water, from Curcuma phaeocaulis Val. in Zingiberaceae, Curcuma Kwangsiensis S. G. Lee et C. F. Liang, or Curcuma wenyujin Y. H. Chen et C. Ling. H. Chen et C. Ling.
Uses
Curcumol is a potential treatment for advanced hepatocellular carcinoma (HCC). It can be used as a chemotherapeutic sensitiser in order to enhance the anti-tumour effect of chemotherapeutic drugs. Studies have shown that it promotes HCC cell apoptosis in vitro and inhibits HCC tumour growth in vivo. It combined with lenvatinib can induce more autolysosome formation, which can enhance the anti-tumour effect of lenvatinib on hepatocellular carcinoma cells.
Definition
ChEBI: Curcumol is a sesquiterpenoid.
Biological Activity
Curcumol is a biologically active sesquiterpene with many pharmacological activities such as anticancer, antimicrobial, antifungal, antiviral and anti-inflammatory. It efficiently induces apoptosis in many cancer cells by targeting key signaling pathways such as MAPK/ERK, PI3K/Akt and NF-κB, which are often dysregulated in several cancers.
Pharmacokinetics
Curcumol is rapidly absorbed and eliminated in rats following oral administration of 10, 40 and 80 mg/kg curcumol. Its oral and intravenous bioavailability ranges from 9.2% ~ 13.1%. Maximum concentration is reached within 0.5-1.0 hours. In addition, high protein binding of curcumin was observed in rat plasma, ranging from 85.6% to 93.4%.
in vitro
Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae . Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. It induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. It suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways.
References
[1] Wei Wei. “Curcumol: From Plant Roots to Cancer Roots.” International Journal of Biological Sciences 27 1 (2019): 1600–1609.
[2] Ying Liu. “Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling.” Cell Death Discovery 10 1 (2024): 300.
Curcumol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haimen DsHare Pharmaceutical Technology Co., Ltd. | +86-0513-68050135 13962878782 | zhuwdsh@126.com | China | 155 | 58 |
| Chengdu Ainahua Chemicals Co., Ltd. | 028-86612776; 13699069380 | 515238037@qq.com | China | 970 | 55 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
View Latest Price from Curcumol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Curcumol
4871-97-0
|
$61.00-148.00 | 99.39% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Curcumol
4871-97-0
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2023-02-13 | Curcumol
4871-97-0
|
$110.00 | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd |
