Exo-1
- CAS No.
- 75541-83-2
- Chemical Name:
- Exo-1
- Synonyms
- EXO1;EOX 1;NSC 214045;Exo1, 10 mM in DMSO;EXOCYTIC INHIBITOR 1;4-FLUORO-BZ-2-ABZ-OME;2-(4-Fluoro-benzoylami;Exo 1 >=98% (HPLC), solid;Exo1 - CAS 75541-83-2 - Calbiochem;Exo1,inhibit,Exo-1,Exo 1,Inhibitor
- CBNumber:
- CB0713355
- Molecular Formula:
- C15H12FNO3
- Molecular Weight:
- 273.26
- MDL Number:
- MFCD00028104
- MOL File:
- 75541-83-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 333.942±27.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.299±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | +2C to +8C |
| solubility | DMSO: 19 mg/mL, soluble |
| form | solid |
| pka | 12.781±0.70(predicted) |
| color | White to off-white |
| InChI | 1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18) |
| InChIKey | KIAPWMKFHIKQOZ-UHFFFAOYSA-N |
| SMILES | COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2 |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Exo-1 price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8280 | Exo 1 ≥98% (HPLC), solid | 75541-83-2 | 5mg | $64.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 341220 | Exo1 | 75541-83-2 | 25mg | $170 | 2026-04-30 | Buy |
| Cayman Chemical | 18455 | Exo1 ≥98% | 75541-83-2 | 10mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 18455 | Exo1 ≥98% | 75541-83-2 | 50mg | $357 | 2026-04-30 | Buy |
| Usbiological | 561856 | EXO1 PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy |
Exo-1 Chemical Properties, Uses, Production
Uses
Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus.
Uses
Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity.
Uses
Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the longinterspersednuclearelement-1 (L1) retrotransposition.
Definition
ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.
Biochem/physiol Actions
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Exo-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 10059 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1883 | 58 |
