| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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- Exo1
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- $38.00
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2026-07-14
- CAS:75541-83-2
- Purity: 99.56%
- Supply Ability: 10g
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| Product Name: | Exo-1 | | Synonyms: | 4-FLUORO-BZ-2-ABZ-OME;2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER;2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE;2-(4-Fluoro-benzoylami;2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate;EOX 1;EXOCYTIC INHIBITOR 1;EXO1 | | CAS: | 75541-83-2 | | MF: | C15H12FNO3 | | MW: | 273.26 | | EINECS: | | | Product Categories: | | | Mol File: | 75541-83-2.mol |  |
| | Exo-1 Chemical Properties |
| Boiling point | 333.942±27.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.299±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | +2C to +8C | | solubility | DMSO: 19 mg/mL, soluble | | form | solid | | pka | 12.781±0.70(predicted) | | color | White to off-white | | InChI | 1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18) | | InChIKey | KIAPWMKFHIKQOZ-UHFFFAOYSA-N | | SMILES | COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Exo-1 Usage And Synthesis |
| Uses | Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus. | | Uses | Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity. | | Uses | Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the longinterspersednuclearelement-1 (L1) retrotransposition. | | Definition | ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides. | | Biochem/physiol Actions | Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies. |
| | Exo-1 Preparation Products And Raw materials |
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